:Ribonuclease (poly-(U)-specific)

{{Infobox enzyme

| Name = Ribonuclease (poly-(U)-specific)

| EC_number = 3.1.26.9

| CAS_number =

| GO_code =

| image =

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Ribonuclease (poly-(U)-specific) ({{EC number|3.1.26.9}}, ribonuclease (uracil-specific), uracil-specific endoribonuclease, uracil-specific RNase) is an enzyme.{{cite journal | vauthors = Bachmann M, Trautmann F, Messer R, Zahn RK, Meyer zum Büschenfelde KH, Müller WE | title = Association of a polyuridylate-specific endoribonuclease with small nuclear ribonucleo-proteins which had been isolated by affinity chromatography using antibodies from a patient with systemic lupus erythematosus | journal = European Journal of Biochemistry | volume = 136 | issue = 3 | pages = 447–51 | date = November 1983 | pmid = 6227485 | doi = 10.1111/j.1432-1033.1983.tb07762.x | doi-access = free }} This enzyme catalyses the following chemical reaction

: Endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups

This enzyme forms oligonucleotides with chain lengths of 6 to 12.