:SKF-97,541

{{Short description|Chemical compound}}

{{cs1 config|name-list-style=vanc}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 451559777

| IUPAC_name = 3-aminopropyl(methyl)phosphinic acid

| image = SKF-97,541.svg

| width = 170

| tradename =

| pregnancy_category =

| legal_status =

| routes_of_administration =

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| IUPHAR_ligand = 1080

| CAS_number_Ref = {{cascite|correct|CAS}}

| CAS_number = 127729-35-5

| ATC_prefix = none

| ATC_suffix =

| ChEMBL = 112710

| PubChem = 5230

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 5040

| C=4 | H=12 | N=1 | O=2 | P=1

| smiles = CP(=O)(CCCN)O

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = NHVRIDDXGZPJTJ-UHFFFAOYSA-N

}}

SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABA_B receptor agonist.{{cite journal | vauthors = Seabrook GR, Howson W, Lacey MG | title = Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices | journal = British Journal of Pharmacology | volume = 101 | issue = 4 | pages = 949–57 | date = December 1990 | pmid = 1964824 | pmc = 1917862 | doi = 10.1111/j.1476-5381.1990.tb14186.x }} It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction.{{cite journal | vauthors = Jackson GL, Kuehl D | title = The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep | journal = Experimental Biology and Medicine | volume = 227 | issue = 5 | pages = 315–20 | date = May 2002 | pmid = 11976401 | doi = 10.1177/153537020222700503 | s2cid = 35467974 }}{{cite journal | vauthors = Besheer J, Lepoutre V, Hodge CW | title = GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice | journal = Psychopharmacology | volume = 174 | issue = 3 | pages = 358–66 | date = July 2004 | pmid = 14985930 | doi = 10.1007/s00213-003-1769-3 | s2cid = 25036152 }}{{cite journal | vauthors = Carter LP, Chen W, Coop A, Koek W, France CP | title = Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348 | journal = European Journal of Pharmacology | volume = 538 | issue = 1–3 | pages = 85–93 | date = May 2006 | pmid = 16647701 | doi = 10.1016/j.ejphar.2006.03.039 }}{{cite journal | vauthors = Koek W, Mercer SL, Coop A | title = Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348 | journal = Psychopharmacology | volume = 192 | issue = 3 | pages = 407–14 | date = June 2007 | pmid = 17277933 | doi = 10.1007/s00213-007-0718-y | s2cid = 25049526 }}{{cite journal | vauthors = Koek W, Mercer SL, Coop A, France CP | title = Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348) | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 330 | issue = 3 | pages = 876–83 | date = September 2009 | pmid = 19564487 | pmc = 2729800 | doi = 10.1124/jpet.109.151845 }}{{cite journal | vauthors = Frankowska M, Nowak E, Filip M | title = Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats | journal = Pharmacological Reports | volume = 61 | issue = 6 | pages = 1042–9 | year = 2009 | pmid = 20081239 | doi = 10.1016/s1734-1140(09)70166-5 | s2cid = 4723878 }}{{cite journal | vauthors = Ranson DC, Ayoub SS, Corcoran O, Casalotti SO | title = Pharmacological targeting of the GABA B receptor alters Drosophila's behavioural responses to alcohol | journal = Addiction Biology | volume = 25 | issue = 2 | year = 2020 | pages = e12725 | pmid = 30761704 | doi = 10.1111/adb.12725 | pmc = 7050513 | doi-access = free }}{{cite journal | vauthors = Gawlińska K, Jastrzębska J, Gamberini S, Gawliński D, Pieniążek R, Suder A, Wydra K, Frankowska M | title = The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression | journal = European Journal of Pharmacology | volume = 883 | issue = | pages = 173324 | date = September 2020 | pmid = 32621910 | doi = 10.1016/j.ejphar.2020.173324 | s2cid = 220348380 }}