:Sceptrin

{{Chembox

| ImageFile = Sceptrin.svg

| ImageAlt =

| SystematicName = N,N′-{[(1R,2R,3S,4S)-3,4-Bis(2-amino-1H-imidazol-5-yl)cyclobutane-1,2-diyl]bis(methylene)}bis(4-bromopyrrole-2-carboxamide)

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|Section1={{Chembox Identifiers

| CASNo = 79638-16-7

| CASNo_Ref = {{Cascite|changed|CAS}}

| ChEBI = 80954

| ChemSpiderID = 138516

| ChEMBL = 307456

| KEGG = C17166

| PubChem = 157394

| SMILES = C1=C(NC=C1Br)C(=O)NC[C@@H]2[C@H]([C@@H]([C@H]2C3=CN=C(N3)N)C4=CN=C(N4)N)CNC(=O)C5=CC(=CN5)Br

| InChI = 1/C22H24Br2N10O2/c23-9-1-13(27-3-9)19(35)29-5-11-12(6-30-20(36)14-2-10(24)4-28-14)18(16-8-32-22(26)34-16)17(11)15-7-31-21(25)33-15/h1-4,7-8,11-12,17-18,27-28H,5-6H2,(H,29,35)(H,30,36)(H3,25,31,33)(H3,26,32,34)/t11-,12-,17-,18-/m1/s1

| InChIKey = YPZNLFZLPZWWAD-GWIYSAMLBB

| StdInChI = 1S/C22H24Br2N10O2/c23-9-1-13(27-3-9)19(35)29-5-11-12(6-30-20(36)14-2-10(24)4-28-14)18(16-8-32-22(26)34-16)17(11)15-7-31-21(25)33-15/h1-4,7-8,11-12,17-18,27-28H,5-6H2,(H,29,35)(H,30,36)(H3,25,31,33)(H3,26,32,34)/t11-,12-,17-,18-/m1/s1

| StdInChIKey = YPZNLFZLPZWWAD-GWIYSAMLSA-N

}}

|Section2={{Chembox Properties

| C=22 | H=24 | Br=2 | N=10 | O=2

| Appearance =

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|Section3={{Chembox Hazards

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Sceptrin is a bioactive marine isolate.{{cite journal|pmid=20030414|year=2010|last1=Cipres|first1=A|last2=O'Malley|first2=DP|last3=Li|first3=K|last4=Finlay|first4=D|last5=Baran|first5=PS|last6=Vuori|first6=K| authorlink5 = Phil S. Baran | title=Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines|volume=5|issue=2|pages=195–202|doi=10.1021/cb900240k|pmc=2825093|journal=ACS Chemical Biology}} It has been isolated from the marine sponge Agelas conifera and appears to have affinity for the bacterial actin equivalent MreB.{{cite journal|pmid=18479102|year=2008|last1=Rodriguez|first1=AD|last2=Lear|first2=MJ|last3=La Clair|first3=JJ|title=Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol|volume=130|issue=23|pages=7256–7258|doi=10.1021/ja7114019|journal=J Am Chem Soc}} As such, this compound possess antibiotic potential.{{cn|date=January 2023}}

See also

References