:Sphingomyelin deacylase

{{Infobox enzyme

| Name = Sphingomyelin deacylase

| EC_number = 3.5.1.109

| CAS_number =

| GO_code =

| image =

| width =

| caption =

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Sphingomyelin deacylase ({{EC number|3.5.1.109}}, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase.{{cite journal | vauthors = Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G | title = High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis | journal = The Journal of Investigative Dermatology | volume = 115 | issue = 3 | pages = 406–13 | date = September 2000 | pmid = 10951276 | doi = 10.1046/j.1523-1747.2000.00072.x | doi-access = free }}{{cite journal | vauthors = Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G | title = The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide | journal = The Biochemical Journal | volume = 350 Pt 3 | pages = 747–56 | date = September 2000 | pmid = 10970788 | pmc = 1221306 | doi = 10.1042/0264-6021:3500747 }}{{cite journal | vauthors = Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G | title = Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 83 | issue = 3 | pages = 397–408 | date = March 2003 | pmid = 12649340 | doi = 10.1097/01.lab.0000059931.66821.92 | doi-access = free }} This enzyme catalyses the following chemical reaction

: (1) an N-acyl-sphingosylphosphorylcholine + H₂O $\backslash rightleftharpoons$ a fatty acid + sphingosylphosphorylcholine;

: (2) a D-glucosyl-N-acylsphingosine + H₂O $\backslash rightleftharpoons$ a fatty acid + D-glucosyl-sphingosine

The enzyme is involved in the sphingolipid metabolism in the epidermis.