:Splicing regulatory element

Splicing regulatory element (SRE) are cis-acting sequences in pre-mRNA, which either enhance or silence (suppress) the splicing of introns, or in general regulates the constitutive or alternative splicing of this pre-mRNA. SREs recruit trans-acting splicing factors to activate or suppress the splice site recognition or spliceosome assembly. The "context dependence" of SREs is categorized into at least two studied groups: (a) the location-dependent activity of SREs: the activity varies with the relative positions of SREs in pre-mRNA; (b) the gene-dependent activity of SREs: the SRE activity observed in one gene is lost when the SRE is moved to another gene.

{{Cite journal

| doi = 10.1261/rna.876308

| issn = 1355-8382

| volume = 14

| issue = 5

| pages = 802–813

| last = Wang

| first = Zefeng

|author2=Christopher B. Burge

| title = Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

| journal = RNA

| date = May 2008