:Sweating sickness

{{About|the 16th century disease in England|the 19th century disease in France|Picardy sweat|the benign condition characterized by abnormally increased perspiration|Hyperhidrosis|the tick-borne disease of cattle in Africa|Sweating sickness (cattle)}}

{{Infobox medical condition (new)

| name = Sweating sickness

| synonyms = English sweating sickness, English sweat, (Latin) sudor anglicus

| image = Illness of the Duke of Normandy.jpg

| caption = Illustration by the Virgil Master depicting the sweating sickness

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| symptoms = chills, pains, weakness

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| causes = Unknown

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Sweating sickness, also known as the sweats, English sweating sickness, English sweat or sudor anglicus in Latin, was a mysterious and contagious disease that struck England and later continental Europe in a series of epidemics beginning in 1485. Other major outbreaks of the English sweating sickness occurred in 1508, 1517, and 1528, with the last outbreak in 1551, after which the disease apparently vanished. The onset of symptoms was sudden and death often occurred within hours. Sweating sickness epidemics were unique compared with other disease outbreaks of the time: whereas other epidemics were typically urban and long-lasting, cases of sweating sickness spiked and receded very quickly, and heavily affected rural populations. Its cause remains unknown, although it has been suggested that an unknown species of hantavirus was responsible.

Signs and symptoms

John Caius was a physician in Shrewsbury in 1551, when an outbreak occurred, and he described the symptoms and signs of the disease in A Boke or Counseill Against the Disease Commonly Called the Sweate, or Sweatyng Sicknesse (1552), which is the main historical source of knowledge of the disease. It began very suddenly with a sense of apprehension, followed by cold shivers (sometimes very violent), dizziness, headache, and severe pains in the neck, shoulders, and limbs, with great exhaustion. The cold stage lasted from half an hour to three hours, after which the hot and sweating stage began. The characteristic sweat broke out suddenly without any obvious cause. A sense of heat, headache, delirium, rapid pulse, and intense thirst accompanied the sweat. Palpitations and pain in the heart were frequent symptoms. No skin eruptions were noted by observers. In the final stages there was either general exhaustion and collapse, or an irresistible urge to sleep, which Caius thought was fatal if the patient were permitted to give way to it. One attack of the disease did not result in immunity to subsequent occurrences, and some people suffered several bouts before dying.{{cite journal|author1=Heyman P. |author2=Simons L. |author3=Cochez, C. |title=Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses?|journal= Viruses|date= 2014|volume=6|number=1|pages=151–171|doi=10.3390/v6010151|pmid=24402305 |pmc=3917436|doi-access=free}} The disease typically lasted through one full day before recovery or death took place.{{Cite journal|last1=Heyman|first1=Paul|last2=Simons|first2=Leopold|last3=Cochez|first3=Christel|date=January 2014|title=Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses?|journal=Viruses|language=en|volume=6|issue=1|pages=151–171|doi=10.3390/v6010151|pmid=24402305|pmc=3917436|doi-access=free}} The disease tended to occur in summer and early autumn.

Thomas Forestier, a physician during the first outbreak, provided a written account of his own experiences with the sweating sickness in 1485. Forestier put great emphasis on the sudden breathlessness commonly associated with the final hours of sufferers. Forestier claimed in an account written for other physicians that "loathsome vapours" had congregated around the heart and lungs. His observations point towards a pulmonary component of the disease.

Cause

The cause is unknown. Commentators then and now have blamed the sewage, poor sanitation, and contaminated water supplies. The first confirmed outbreak was in August 1485 at the end of the Wars of the Roses, leading to speculation that it may have been brought from France by French mercenaries.{{cite book |last1=Theilmann |first1=John M. |editor1-last=Byrnes |editor1-first=Joseph P. |title=Encyclopedia of pestilence, pandemics, and plagues |date=2008 |publisher=Greenwood Press |isbn=978-0313341014 |page=686, "Sweating Sickness" }} However, an earlier outbreak may have affected the city of York in June 1485, before Henry Tudor's army landed, although records of that disease's symptoms are not adequate enough to be certain.{{cite book |last1=Petre |first1=James |title=Richard III crown and people |date=1985 |publisher=Sutton Publishing Ltd |isbn=978-0904893113 |page=383 |quote=A 'plage of pestilence' was known in York as early as June 1485, but no symptoms were described, and we cannot tell what gave [Sir Thomas] Stanley the idea to cite the sweating sickness.}} Regardless, the Croyland Chronicle mentions that Thomas Stanley, 1st Earl of Derby cited the sweating sickness as reason not to join Richard III's army prior to the Battle of Bosworth.

Relapsing fever, a disease spread by ticks and lice, has been proposed as a possible cause. It occurs most often during the summer months, as did the original sweating sickness. However, relapsing fever is marked by a prominent black scab at the site of the tick bite and a subsequent rash, neither of which are described as the symptoms of sweating sickness.

The suggestion of ergotism was ruled out due to England growing much less rye (which ergots typically grow on) than the rest of Europe.

Researchers have noted symptoms overlap with hantavirus pulmonary syndrome and have proposed an unknown hantavirus as the cause.{{Cite journal|pmid=9023099|year=1997|last1=Thwaites|first1=G|author1-link=Guy Thwaites|last2=Taviner|first2=M|last3=Gant|first3=V|title=The English sweating sickness, 1485 to 1551|volume=336|issue=8|pages=580–582|doi=10.1056/NEJM199702203360812|journal=The New England Journal of Medicine}}{{cite journal|pmc=1043971|year=1998|last1=Taviner|first1=M|last2=Thwaites|first2=G|last3=Gant|first3=V|title=The English sweating sickness, 1485–1551: A viral pulmonary disease?|volume=42|issue=1|pages=96–98|journal=Medical History|doi=10.1017/S0025727300063365|pmid=9536626}} Hantavirus species are zoonotic diseases carried by bats, rodents, and several insectivores.{{Cite journal|last1=Heyman|first1=Paul|last2=Simons|first2=Leopold|last3=Cochez|first3=Christel|date=2014-01-07|title=Were the English Sweating Sickness and the Picardy Sweat Caused by Hantaviruses?|journal=Viruses|language=en|volume=6|issue=1|pages=151–171|doi=10.3390/v6010151|issn=1999-4915|pmc=3917436|pmid=24402305|doi-access=free}} Sharing of similar trends (including seasonal occurrences, fluctuations multiple times a year, and occasional occurrences between major outbreaks) suggest the English sweating sickness may have been rodent-borne. The epidemiology of hantavirus correlates with the trends of the English sweating sickness. Hantavirus infections generally do not strike infants, children, or the elderly, and mostly affect middle-aged adults. In contrast to most epidemics of the medieval ages, the English sweating sickness also predominantly affected the middle-aged. A criticism of this hypothesis is that modern-day hantaviruses, unlike the sweating sickness, do not randomly disappear and can be seen affecting isolated people. Another is that sweating sickness was thought to have been transmitted from human to human, whereas hantaviruses are rarely spread that way.{{cite journal|pmid=11284216 |title=The English 'sweate' (Sudor Anglicus) and Hantavirus pulmonary syndrome|journal=British Journal of Biomedical Science |year=2001 |last=Bridson |first= Eric|volume=58|issue=1|pages=1–6}} However, infection via human contact has been suggested in hantavirus outbreaks in Argentina.{{cite journal|last1=Padula|first1=P|last2=Edelstein|first2=A|last3=Miguel|first3=SD|last4=López|first4=NM|last5=Rossi|first5=CM|last6=Rabinovich |first6=RD|date=15 February 1998|title=Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus|journal=Virology|publisher=Elsevier|location=London|volume=241|issue=2|pages=323–330|doi=10.1006/viro.1997.8976|pmid=9499807|doi-access=free}}

In 2004, microbiologist Edward McSweegan suggested the disease may have been an outbreak of anthrax poisoning. He hypothesised that the victims could have been infected with anthrax spores present in raw wool or infected animal carcasses, and suggested exhuming victims for testing.{{cite journal |url=https://www.newscientist.com/article/mg18124302.400-riddle-solved.html |title=Riddle solved? |date=17 January 2004 |journal=New Scientist |author=McSweegan, Edward |access-date=27 June 2018 |archive-date=23 May 2015 |archive-url=https://web.archive.org/web/20150523105717/http://www.newscientist.com/article/mg18124302.400-riddle-solved.html |url-status=live }}

Numerous attempts have been made to define the disease origin by molecular biology methods, but have so far failed due to a lack of available DNA or RNA.{{cite journal|year=2018|url=https://www.researchgate.net/publication/326092598|title=The English Sweating Sickness: Out of Sight, Out of Mind?|volume=47|issue=1|pages=102–116|doi=10.5644/ama2006-124.22|journal=Acta Medica Academica|author=Paul Heyman, Christel Cochez, Mirsada Hukić|pmid=29957978|doi-access=free|access-date=20 August 2020|archive-date=1 February 2021|archive-url=https://web.archive.org/web/20210201052157/https://www.researchgate.net/publication/326092598_The_English_Sweating_Sickness_Out_of_Sight_Out_of_Mind|url-status=live}}

= Transmission =

Transmission mostly remains a mystery, with only a few pieces of evidence in writing. Despite greatly affecting the rural and working classes of the time, the sweating sickness did not discriminate, as it was no less likely to affect young, seemingly fit men, including those of the elite or privileged classes. Based upon recorded accounts, the mortality rate among victims was highest in males aged 30–40 years. The fact that it infected all levels of society, from rich to poor, earned the sweating sickness various nicknames, such as "Stoop Gallant" or "Stoop Knave" — referencing how the 'proud' castes were forced to 'stoop' and face their own humanity.

The large number of people present in London to witness the coronation of Henry VII may have accelerated the spread of the disease, and indeed many other airborne pathogens.

Epidemiology

=Fifteenth century=

File:Arthur Prince of Wales c 1500.jpg, who may have died of the sweating sickness in 1502, aged fifteen]]

Sweating sickness first came to the attention of physicians at the beginning of the reign of Henry VII, in 1485. It was frequently fatal; half the population perished in some areas. The Ricardian scholar John Ashdown-Hill conjectures that Richard III fell victim the night before the Battle of Bosworth Field and that this accounted for his sleepless night and excessive thirst in the early part of the battle.{{cite book | first=John | last=Ashdown-Hill | author-link=John Ashdown Hill | year=2015 | title=The Mythology of Richard III}} There is no definitive statement that the sickness was present in Henry Tudor's troops landing at Milford Haven. The battle's victor, Henry VII, arrived in London on 28 August, and the disease broke out there on 19 September 1485;{{cite journal|pmc=2059547|year=1945|last1=Roberts|first1=L|title=Sweating Sickness and Picardy Sweat|journal=British Medical Journal|volume=2|issue=4414|pages=196|doi=10.1136/bmj.2.4414.196}} it had killed several thousand people by its conclusion in late October that year.{{cite book | first=John | last=Entick | author-link=John Entick | year=1766 | title=A new and accurate history and survey of London, Westminster, Southwark, and places adjacent | url=https://archive.org/details/anewandaccurate03entigoog | location=London | pages=[https://archive.org/details/anewandaccurate03entigoog/page/n438 434], vol. 1 }} Among those killed were two lord mayors, six aldermen, and three sheriffs.{{cite book | first=Walter | last=Harrison | year=1775 | title=A new and universal history, description and survey of the cities of London and Westminster, the borough of Southwark | location=London | page=127 }}

Mass superstition and paranoia followed the new plague. The Battle of Bosworth Field ended the Wars of the Roses, between the houses of Lancaster and York. Richard III, the final York king, was killed there and Henry VII was crowned. As chaos, grief, and anger spread, people searched for a culprit for the plague. English people started to believe it was sent by God to punish supporters of Henry VII.{{Cite journal|last1=Schölpfel|first1=Joachim|last2=Soukouya|first2=Maebena|date=November 2013|title=Providing Access to Electronic Theses and Dissertations: A Case Study from Togo|journal=D-Lib Magazine|volume=19|issue=11/12|doi=10.1045/november2013-schopfel|issn=1082-9873|doi-access=free}}

Because of its extremely rapid and fatal course, and the sweating which gave it its name, the sickness was regarded as being quite distinct from the Black Death, the pestilential fever, or other epidemics previously known. It reached Ireland in 1492 when the Annals of Ulster record the death of James Fleming, 7th Baron Slane from the pláigh allais ["perspiring plague"], newly come to Ireland.Annals of Ulster vol.iii, ed. B. MacCarthy, Dublin, 1895, pp. 358f. The Annals of Connacht also record this obituary,Annals of Connacht ed. A. M. Freeman, Dublin, 1944, pp. 594f. and the Annals of the Four Masters record "an unusual plague in Meath" of 24 hours' duration;Annals of the Four Masters vol.iii, ed. J. O'Donovan, Dublin, 1856, pp 1194f. people recovered if they survived it beyond that 24-hour period. The sickness didn't affect infants or young children. English chronicler Richard Grafton mentioned the sweating sickness of 1485 in his work Grafton's Chronicle: or History of England. He noted the common treatment of the disease was to go immediately to bed at the first sign of symptoms; there, the affected person was to remain still for the entire 24-hour period of the illness, abstaining from any solid food and limiting water intake.{{Cite journal|last=Grafton|first=Richard|date=1809|title=Grafton's chronicle: or, History of England from the Year 1189 to 1558|url=https://archive.org/details/graftonschronicl02grafuoft/page/154/|journal=The Library|volume=2|pages=161|doi=10.1093/oxfordjournals.library.a090806|issn=1744-8581}}

=Sixteenth century=

File:Hans Holbein the Younger - Henry Brandon, 2nd Duke of Suffolk (1535-51) - Google Art Project.jpg, who in 1551 died of the sweating sickness aged fifteen, just an hour before his brother Charles also succumbed]]

The ailment was not recorded from 1492 to 1502. It may have been the condition which afflicted Henry VII's son Arthur, Prince of Wales, and Arthur's wife, Catherine of Aragon, in March 1502; their illness was described as "a malign vapour which proceeded from the air".{{cite book | title=The Six Wives of Henry VIII | publisher=Grove Press | last=Weir | first=Alison | year=2007 | location=New York | isbn=978-0-8021-3683-1 | page=[https://archive.org/details/sixwivesofhenryv00weir_1/page/37 37] | url-access=registration | url=https://archive.org/details/sixwivesofhenryv00weir_1 }}{{cite book | title=The Virgin Queen: A Personal History of Elizabeth I | publisher=Viking Press | last=Hibbert | first=Christopher | year=2010 | location=New York | isbn=978-1-84885-555-7 | page=4}} Researchers who opened Arthur's tomb in 2002 could not determine the exact cause of death. Catherine recovered, but Arthur died on 2 April 1502 in his home at Ludlow Castle, six months short of his sixteenth birthday.{{cite book | title=Henry VIII | publisher=Oxford University Press | last=Ives | first=Eric | year=2007 | location=Oxford | isbn=978-0-19-921759-5 | page=1}}

A second, less widespread outbreak occurred in 1507, followed by a third and much more severe epidemic in 1517, a few cases of which may have also spread to Calais. In the 1517 epidemic, the disease showed a particular affinity for the English; the ambassador from Venice at the time commented on the peculiarly low number of cases in foreign visitors. A similar effect was noted in 1528 when Calais (then an English territory) experienced an outbreak that did not spread into France. The 1528 outbreak, the fourth, reached epidemic proportions. The earliest written reference to it was on 5 June 1528, in a letter to Bishop Tunstall of London from Brian Tuke, who said that he had fled to Stepney to avoid infection from a servant at his house who was ill with "the sweat.",Charles Creighton, [https://books.google.com/books?id=kRMLAAAAIAAJ&q=%22sweating+sickness%22+1528 A History of Epidemics in Britain from A.D. 664 to the Extinction of Plague] (Cambridge University Press, 1891) pp.250-251 suggesting that it broke out in London at the end of May. The sweats spread over the whole of England, save the far north. It did not spread to Scotland, though it did reach Ireland where Lord Chancellor Hugh Inge, who died on 3 August 1528, was the most prominent victim.{{cite book|first=F. Elrington|last=Ball|author-link=F. Elrington Ball|title=The Judges in Ireland, 1221–1921|url=https://books.google.com/books?id=rqeSXWqKAD8C&pg=PA117|access-date=5 May 2011|date=2005|orig-year=First published 1926|publisher=The Lawbook Exchange|isbn=978-1-58477-428-0|pages=117–}} Mortality was very high in London; Henry VIII broke up the court and left London, frequently changing his residence. In 1529 Thomas Cromwell lost his wife and two daughters to the disease. It is believed several of the closest people to Henry VIII contracted the sickness. His love letters to his mistress, Anne Boleyn, reveal that physicians believed Anne had contracted the illness. Henry sent his second-most trusted physician to her aid, his first being unavailable, and she survived.{{Cite book|last=Henry VIII, King of England|date=April 27, 2010|title=The Love Letters of Henry VIII to Anne Boleyn; With Notes|url=http://www.gutenberg.org/ebooks/32155|via=Project Gutenberg|access-date=7 December 2020|chapter=Letter Ninth|archive-date=3 May 2019|archive-url=https://web.archive.org/web/20190503065646/http://www.gutenberg.org/ebooks/32155|url-status=live}} Cardinal Wolsey contracted the illness and survived.{{Cite book|last=Grove|first=Joseph|title=The history of the life and times of Cardinal Wolsey, prime minister to King Henry Viii. I. Of his Birth, and the various Steps he took to attain Preferment, connected with Affairs, both Foreign and Domestick, from the Death of Edward IV. to the End of the Reign of Henry Vii. II. Of his Conduct and Management while Prime Minister, (commencing with the Reign of Henry Viii.) and continued by way of Annals to his Disgrace and Death, including the general Transactions of Europe. III. Memoirs of the Emperor Charles V. Henry Viii. and Francis I. from the Demise of the Cardinal to their respective Deaths. IV. The secret History of the Cardinal, by George Cavendish, Esq; his Gentleman Usher, written in the Reign of Philip and Mary. In which are interspersed The Lives and memorable Actions of the most eminent Persons: And the whole illustrated with Political and Moral Reflections. Collected from antient Records, Manuscripts, and Historians. ... . Adorn'd with Cuts, and a compleat Index|publisher=printed by J. Purser, for the author, and sold by J. Stagg, in Westminster-Hall; J. Brindley, in Bond-Street; R. Chandler and C. Ward, at Temple-Bar, York and Scarborough; L. Gilliver, and J. Whiston, in Fleet-Street; J. Huggonson, on Ludgate-Hill; T. Astley, in St. Paul's Church-Yard; R. Willock, J. Wood, J. Clarke, and W. Meadows, in Cornhill; and J. Walthoe, at Richmond in Surry. (London) Volume: 3|year=1742|pages=7–20}}

The disease was brought to Hamburg by a ship from England in July 1529.{{Cite book|last=Gruner|first=Christian Gottfried|date=1847|title=Scriptores de sudore anglico superstites|url=https://archive.org/details/b28038071|via=Internet Archive|access-date=3 February 2024|pages=443–444}} It spread along the Baltic coast, north to Denmark, Sweden, and Norway as well as south to Strasbourg, Frankfurt, Cologne, Marburg, and Göttingen in September of that year.{{cite journal|pmc=2706052|year=2009|last1=Christiansen|first1=John|title=The English Sweat in Lübeck and North Germany, 1529|journal=Medical History|volume=53|issue=3|pages=415–24|doi=10.1017/s0025727300004002|pmid=19584960 }} Cases were unknown in Italy or France, except in the English-controlled Pale of Calais. It emerged in Flanders and the Netherlands, possibly transmitted directly from England by travellers; it appeared simultaneously in the cities of Antwerp and Amsterdam on the morning of 27 September. In each place, it prevailed for a short time, generally not more than two weeks. By the end of 1529, it had entirely disappeared except in the eastern part of the Swiss Confederacy, where it lingered into the next year. The disease did not recur in mainland Europe.

=Final outbreak=

File:Hans Holbein the Younger - Charles Brandon (Royal Collection).JPG, died of the sweating sickness aged thirteen, having held the dukedom for just an hour after his elder brother died of the disease]]

The last major outbreak of the disease occurred in England in 1551.{{Cite journal|title=The English Sweating Sickness, with Particular Reference to the 1551 Outbreak in Chester|author=Hunter, Paul R.|year=1991|journal=Reviews of Infectious Diseases|volume=13|issue=2|pages=303–306|jstor = 4455857|doi = 10.1093/clinids/13.2.303|pmid = 2041963}} Although burial patterns in smaller towns in Europe suggest that the disease may have been present elsewhere first, the outbreak is recorded to have begun in Shrewsbury in April.{{Cite journal|last1=WYLIE|first1=JOHN A. H.|last2=COLLIER|first2=LESLIE H.|date=1981|title=The English Sweating Sickness (Sudor Anglicus): A Reappraisal|url=http://dx.doi.org/10.1093/jhmas/xxxvi.4.425|journal=Journal of the History of Medicine and Allied Sciences|volume=XXXVI|issue=4|pages=425–445|doi=10.1093/jhmas/xxxvi.4.425|pmid=7037928|issn=0022-5045|access-date=6 November 2020|archive-date=1 February 2021|archive-url=https://web.archive.org/web/20210201052137/https://academic.oup.com/jhmas/article-abstract/XXXVI/4/425/706250?redirectedFrom=fulltext|url-status=live}} It killed around 1,000 there, spreading quickly throughout the rest of England{{Cite journal|last=Dyer|first=Alan|date=1997|title=The English Sweating Sickness of 1551: An Epidemic Anatomized|journal=Medical History|language=en|volume=41|issue=3|pages=362–384|doi=10.1017/S0025727300062724|pmid=9327632|pmc=1044802|issn=0025-7273}} and all but disappearing by October. It was more prevalent among younger men than other groups, possibly due to their greater social exposure. John Caius wrote his eyewitness account A Boke or Counseill Against the Disease Commonly Called the Sweate, or Sweatyng Sicknesse. Henry Machin also recorded it in his diary:

{{Blockquote|text=

the vii day of July begane a nuw swet in London…the x day of July [1551] the Kynges grace removyd from Westmynster unto Hamtun courte, for ther [died] serten besyd the court, and caused the Kynges grase to be gone so sune, for ther ded in London mony marchants and grett ryche men and women, and yonge men and old, of the new swett…the xvi day of July ded of the swet the ii yonge dukes of Suffoke of the swet, both in one bed in Chambrydge-shyre…and ther ded from the vii day of July unto the xix ded of the swett in London of all dyssesus… [872] and no more in alle|sign=The Diary of Henry Machyn 1550–1563{{citation|title=The Diary of Henry Machyn 1550–1563|date=1848|author=Henry Machin|pages=7–8|url=https://archive.org/stream/henrymachyncit00camduoft#page/6/mode/2up}}|}}

The Annals of Halifax Parish of 1551 records 44 deaths in an outbreak there.{{Cite journal|last=Taylor|first=D|title=Annals of the Parish of Halifax|journal=Halifax Antiquarian Society|date=28 March 1972|page=109|quote=1551 44 persons died of the 'sweating Sickness' in the Halifax Parish.}} An outbreak called 'sweating sickness' occurred in Tiverton, Devon in 1644, recorded in Martin Dunsford's History, killing 443 people, 105 of them buried in October.{{Cite journal|last=Dunsford|first=Martin|title=Historical memoirs of the town and parish of Tiverton|date=1836|page=36}} However, no medical particulars were recorded, and the date falls well after the generally accepted disappearance of the 'sweating sickness' in 1551.{{cite book |last1=Creighton |first1=Charles |title=A history of epidemics in Britain |date=1891 |publisher=Cambridge Univ. |page=[https://archive.org/details/historyofepidemi01crei/page/554 554] |url=https://archive.org/details/historyofepidemi01crei |access-date=5 October 2019}}

Picardy sweat

File:Euricius cordus - englisch schweiss.jpg, 1529, about the English Sweating sickness]]

Between 1718 and 1918 an illness with some similarities occurred in France, known as the Picardy sweat.{{cite book|last=Foster|first=Michael G.|title=Contributions to Medical & Biological Research|chapter=Sweating Sickness in Modern Times|pages=52–53|volume=1|publisher=Paul B. Hoeber|location=New York|date=1919|chapter-url=https://archive.org/details/contributionstom01osleuoft|via=Internet Archive}} It was significantly less lethal than the English Sweat but with a strikingly high frequency of outbreaks; some 200 were recorded during the period. Llywelyn Roberts noted "a great similarity between the two diseases." There was intense sweating and fever, and Henry Tidy found "no substantial reason to doubt the identity of sudor anglicus and Picardy sweat."{{cite journal| pmc=2059374 | pages=63–64 | volume=2 | issue=4410 | journal=Br Med J | title=Sweating Sickness and Picardy Sweat | year=945 | doi=10.1136/bmj.2.4410.63-a|last1 = Tidy|first1 = H.}} There were also notable differences between the Picardy sweat and the English sweating sickness. It was accompanied by a rash, which was not described as a feature of the English disease. Henry Tidy argued that John Caius's report applies to fulminant cases fatal within a few hours, in which case no eruption may develop. The Picardy sweat appears to have had a different epidemiology than the English sweat in that individuals who slept close to the ground and/or lived on farms appeared more susceptible, supporting the theory that the disease could be rodent-borne, common in hantaviruses. In a 1906 outbreak of Picardy sweat which struck 6,000 people, a commission led by bacteriologist André Chantemesse attributed infection to the fleas of field mice.{{cn|date=March 2025}}

Citations

Sources

{{EB1911|wstitle=Sweating-Sickness|volume=26|pages=186–187}}
{{cite book |title=Life and Writings of Blessed Thomas More, Lord Chancellor of England and Martyr Under Henry VIII. |last=Bridgett |first=Thomas Edward |year=1904 |location=Original from the University of Wisconsin – Madison |page=74 |url=https://books.google.com/books?id=v3xmAAAAMAAJ&q=thomas+more+sweating+sickness&pg=PA74}}

External links

[http://www.abc.net.au/rn/ockhamsrazor/stories/2007/2039403.htm Sweating Fever] Jim Leavesley commemorates the 500th anniversary of the first outbreak – transcript of talk on Ockham's Razor, ABC Radio National
[http://discovermagazine.com/1997/jun/thesweatingsickn1161 "The Sweating Sickness Returns"], Discover Magazine, 1 June 1997

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Category:1485 disasters