:TRNA (guanine10-N2)-dimethyltransferase

{{Infobox enzyme

| Name = TRNA (guanine¹⁰-N²)-dimethyltransferase

| EC_number = 2.1.1.213

| CAS_number =

| GO_code =

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TRNA (guanine¹⁰-N²)-dimethyltransferase ({{EC number|2.1.1.213}}, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine¹⁰-N²)-dimethyltransferase.{{cite journal | vauthors = Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H | title = N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota | journal = The Journal of Biological Chemistry | volume = 279 | issue = 35 | pages = 37142–52 | date = August 2004 | pmid = 15210688 | doi = 10.1074/jbc.m403845200 | doi-access = free | url = http://agritrop.cirad.fr/602184/1/Publi11.pdf }} This enzyme catalyses the following chemical reaction

: 2 S-adenosyl-L-methionine + guanine¹⁰ in tRNA $\backslash rightleftharpoons$ 2 S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA (overall reaction)

:(1a) S-adenosyl-L-methionine + guanine¹⁰ in tRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + N²-methylguanine¹⁰ in tRNA

:(1b) S-adenosyl-L-methionine + N²-methylguanine¹⁰ in tRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + N²-dimethylguanine¹⁰ in tRNA