:TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

{{Short description|Enzyme}}

{{Infobox enzyme

| Name = TRNA (guanine²⁶-N²/guanine27-N²)-dimethyltransferase

| EC_number = 2.1.1.215

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

TRNA (guanine²⁶-N²/guanine²⁷-N²)-dimethyltransferase ({{EC number|2.1.1.215}}, Trm1, tRNA (N²,N²-guanine)-dimethyltransferase, tRNA (m2(2G26) methyltransferase, Trm1[tRNA (m2(2)G26) methyltransferase]) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine²⁶-N²/guanine²⁷-N²)-dimethyltransferase.{{cite journal | vauthors = Awai T, Kimura S, Tomikawa C, Ochi A, Bessho Y, Yokoyama S, Ohno S, Nishikawa K, Yokogawa T, Suzuki T, Hori H | title = Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA | journal = The Journal of Biological Chemistry | volume = 284 | issue = 31 | pages = 20467–78 | date = July 2009 | pmid = 19491098 | pmc = 2742811 | doi = 10.1074/jbc.m109.020024 | doi-access = free }} This enzyme catalyses the following chemical reaction

: 4 S-adenosyl-L-methionine + guanine²⁶/guanine²⁷ in tRNA $\backslash rightleftharpoons$ 4 S-adenosyl-L-homocysteine + N²-dimethylguanine²⁶/N²-dimethylguanine²⁷ in tRNA

The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya.