:TRNA (guanine37-N1)-methyltransferase

{{DISPLAYTITLE:tRNA (guanine³⁷-N¹)-methyltransferase}}

{{Infobox enzyme

| Name = tRNA (guanine³⁷-N¹)-methyltransferase

| EC_number = 2.1.1.228

| CAS_number =

| GO_code =

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tRNA (guanine³⁷-N¹)-methyltransferase ({{EC number|2.1.1.228}}, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine³⁷-N¹)-methyltransferase.{{cite journal | vauthors = Takeda H, Toyooka T, Ikeuchi Y, Yokobori S, Okadome K, Takano F, Oshima T, Suzuki T, Endo Y, Hori H | title = The substrate specificity of tRNA (m¹G³⁷) methyltransferase (TrmD) from Aquifex aeolicus | journal = Genes to Cells | volume = 11 | issue = 12 | pages = 1353–65 | date = December 2006 | pmid = 17121543 | doi = 10.1111/j.1365-2443.2006.01022.x }}{{cite journal | vauthors = Lee C, Kramer G, Graham DE, Appling DR | title = Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase | journal = The Journal of Biological Chemistry | volume = 282 | issue = 38 | pages = 27744–53 | date = September 2007 | pmid = 17652090 | doi = 10.1074/jbc.m704572200 | doi-access = free }}{{cite journal | vauthors = O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brulé H, Petit C, Holmes DJ, Zalacain M, Holmes WM | title = Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth | journal = Journal of Bacteriology | volume = 186 | issue = 8 | pages = 2346–54 | date = April 2004 | pmid = 15060037 | pmc = 412112 | doi = 10.1128/jb.186.8.2346-2354.2004 }}{{cite journal | vauthors = Brulé H, Elliott M, Redlak M, Zehner ZE, Holmes WM | title = Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein | journal = Biochemistry | volume = 43 | issue = 28 | pages = 9243–55 | date = July 2004 | pmid = 15248782 | doi = 10.1021/bi049671q }}{{cite journal | vauthors = Goto-Ito S, Ito T, Ishii R, Muto Y, Bessho Y, Yokoyama S | title = Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5 | journal = Proteins | volume = 72 | issue = 4 | pages = 1274–89 | date = September 2008 | pmid = 18384044 | doi = 10.1002/prot.22019 }}{{cite journal | vauthors = Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK | title = Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition | journal = The EMBO Journal | volume = 22 | issue = 11 | pages = 2593–603 | date = June 2003 | pmid = 12773376 | pmc = 156765 | doi = 10.1093/emboj/cdg269 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine³⁷ in tRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + N¹-methylguanine³⁷ in tRNA

This enzyme is important for the maintenance of the correct reading frame during translation.