:Talk:3,3'-Diindolylmethane

Where does the "Biological Activities of 3,3'-Diindolylmethane" in the picture come from? More should be written about these properties, or the picture should be removed —Preceding unsigned comment added by 84.48.90.60 (talk) 14:26, 1 February 2009 (UTC)

"* [http://otl.berkeley.edu/technology/inventiondetail.php?inventionId=1001026 Plant derived 3,3'-diindolylmethane (DIM) a potent androgen antagonist in prostate cancer cells]"

The document could not be found and no suitable replacement was found Courtland 12:07, July 30, 2005 (UTC)

The article as published is available via [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12665522&dopt=Abstract PMID: 12665522]. - tameeria 05:06, 23 February 2007 (UTC)

I have removed the following block of references

1. Hong, Chibo, Firestone, Gary L., Bjeldanes, Leonard F. (2000). [http://www.ag.uiuc.edu/ffh/abstracts/dim_anticancer.html 3,3'-Diindolylmethane(DIM), a dietary indole, has multiple cell suppressive effects on MCF-7, human breast cancer cells]. Presented at the 40th Annual Meeting of American Society for Cell Biology, December 9-13, 2000, San Francisco. Availability verified July 30, 2005.
2. [http://ctd.mdibl.org/voc.go?voc=chemical&termUI=3,3'-diindolylmethane DIM at the Comparative Toxicogenomics Database prototype]. Availability verified July 29, 2005.
3. Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16267208&query_hl=12&itool=pubmed_docsum Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.] Molecular Pharmacology. 2006 Feb;69(2):430-9. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA.
4. Xue L, Firestone GL, Bjeldanes LF. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15735741&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways.] Department of Nutritional Sciences and Toxicology, University of California, 119 Morgan Hall, Berkeley, CA 94720-3104, USA. Oncogene. 2005 Mar 31;24(14):2343-53.
5. Gong Y, Sohn H, Xue L, Firestone GL, Bjeldanes LF [Db=pubmed&Cmd=ShowDetailView&TermToSearch=16651444&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA. Cancer Research 2006 May 1;66(9):4880-7.
6. K. McGuire, N. Ngoubilly, M. Neavyn, S. Lanza-Jacoby [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16580691&ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells.] Journal of Surgical Research, 2006 May 15;132(2):208-13. Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
7. Staub RE, Onisko B, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16544949&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA. Chemical Research in Toxicology 2006 Mar;19(3):436-42
8. Gong Y, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16385077&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells.] Department of Nutritional Sciences and Toxicology, 119 Morgan Hall, University of California, Berkeley, CA 94720-3104, USA. Molecular Pharmacology 2006 Apr;69(4):1320-7. Epub 2005 Dec 29.
9. Chang X, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16199440&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA. Carcinogenesis 2006 Mar;27(3):541-50. Epub 2005 Sep 30.
10. Chang X, Tou JC, Hong C, Kim HA, Riby JE, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15661811&ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA. Carcinogenesis, 2005 Apr;26(4):771-8. Epub 2005 Jan 20.
11. Leong H, Riby JE, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14645498&ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA. Mol Endocrinol. 2004 Feb;18(2):291-302. Epub 2003 Nov 26.
12. Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12840223&ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.] Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California at Berkeley, Berkeley, CA 94720-3200, USA. J Nutr. 2003 Jul;133(7 Suppl):2448S-2455S.
13. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF, [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12665522&ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells.] Department of Nutritional Sciences and Toxicology, The University of California, Berkeley, California 94720-3104, USA. J Biol Chem. 2003 Jun 6;278(23):21136-45. Epub 2003 Mar 27.
14. Hong C, Kim HA, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12151347&ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA. Carcinogenesis. 2002 Aug;23(8):1297-305.
15. Hong C, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11931841&ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells.] Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3200, USA. Biochem Pharmacol. 2002 Mar 15;63(6):1085-97.
16. Leong H, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11698343&ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression.] Department of Nutritional Sciences and Toxicology, University of California-Berkeley, Berkeley, CA 94720, USA. Carcinogenesis. 2001 Nov;22(11):1809-17.
17. Riby JE, Chang GH, Firestone GL, Bjeldanes LF [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10825461&ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Ligand-independent activation of estrogen receptor function by 3, 3'-diindolylmethane in human breast cancer cells.] Division of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA. Biochem Pharmacol. 2000 Jul 15;60(2):167-77.
18. Chang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF, [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10449193&ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol.] Division of Nutritional Sciences and Toxicology, University of California, Berkeley 94720, USA. Biochem Pharmacol. 1999 Sep 1;58(5):825-34.
19. Chen I, Safe S, Bjeldanes L. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=8866829&ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.] Veterinary Physiology and Pharmacology, Texas A&M University, College Station 77843-4466, USA. Biochem Pharmacol. 1996 Apr 26;51(8):1069-76.
20. Stresser DM, Bjeldanes LF, Bailey GS, Williams DE [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=8568833&ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450.] Department of Food Science and Technology, Oregon State University, Corvallis 97331-6602, USA. J Biochem Toxicol. 1995 Aug;10(4):191-201.

I don't believe most of these have been used as a reference, and I expect that the users who added these 'references' have a conflict of interest with the subject, as well as with a number of the external links added (inline and in external links section). I hope an uninvolved editor will have a look at this. --Dirk Beetstra ^{T C} 07:32, 3 August 2007 (UTC)

:I removed them from the article again for the same reasons. -- Ed (Edgar181) 13:00, 29 May 2011 (UTC)

Whenever I read an article like this or come across sites supporting purported wonder drugs/chemicals to fight cancer, I always get a bit skeptical. Can someone who knows something about this topic speak to how big a deal this really is for this particular compound? Is this something that reasonably stands a chance or is this someone's obsession (like how some people are obsessed with Vitamin C for the common cold or the whole amygdalin/laetrile business)? I also noticed a lot of the claims in the article are flagged as citation needed and I wonder if this whole article was written by someone with a conflict of interest in the subject.

142.103.207.10 (talk) 01:29, 2 December 2010 (UTC)

Several mouse studies, mostly on cancer, some arthritis.

http://www.dimfaq.com/site/inflammation.htm

"In a preliminary study on 64 women, it was well tolerated at the studied dose (2 mg/kg/day), showing some promising results as an immunostimulant against human papilloma virus infection of the cervix, but not at a statistically significant level." (emphasis mine) If it's not "statistically significant", then there are no "promising results". GranoblasticMan (talk) 14:49, 14 April 2016 (UTC)

It should be noted that DIM is a phytoestrogen RummKoolaq (talk) 07:05, 8 December 2023 (UTC)