:Tolonidine

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 444561766

| ImageFile = Tolonidine.svg

| ImageSize = 175

| PIN = N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine

| OtherNames =

| Section1 = {{Chembox Identifiers

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = I4O795Q03O

| CASNo_Ref = {{cascite|correct|??}}

| CASNo = 4201-22-3

| PubChem = 72138

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D07168

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 65112

| SMILES = Clc1cc(C)ccc1NC2=NCCN2

| InChI = 1/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)

| InChIKey = KWBTZIFLQYYPTH-UHFFFAOYAF

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = KWBTZIFLQYYPTH-UHFFFAOYSA-N

}}

| Section2 = {{Chembox Properties

| Formula = C₁₀H₁₂ClN₃

| MolarMass = 209.67538

| Appearance =

| Density =

| MeltingPt =

| BoilingPt =

| Solubility =

}}

| Section6 = {{Chembox Pharmacology

| ATCCode_prefix = C02

| ATCCode_suffix = AC04

}}

| Section7 = {{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt =

}}

}}

Tolonidine is an antihypertensive.{{Cite journal | last1 = Cosnier | first1 = D. | last2 = Duchene-Marullaz | first2 = P. | last3 = Grimal | first3 = J. | last4 = Rispat | first4 = G. | last5 = Streichenberger | first5 = G. | title = Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate | journal = Arzneimittel-Forschung | volume = 25 | issue = 10 | pages = 1557–61 | year = 1975 | pmid = 1243037}}{{Cite journal | last1 = Cosnier | first1 = D. | last2 = Labrid | first2 = C. | last3 = Rispat | first3 = G. | last4 = Streichenberger | first4 = G. | title = Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis | journal = Arzneimittel-Forschung | volume = 25 | issue = 11 | pages = 1802–6 | year = 1975

| pmid = 1243090}}{{Cite journal | last1 = Cosnier | first1 = D. | last2 = Hache | first2 = J. | last3 = Labrid | first3 = C. | last4 = Streichenberger | first4 = G. | title = Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity | journal = Arzneimittel-Forschung | volume = 25 | issue = 12 | pages = 1926–33 | year = 1975 | pmid = 3186}} It is an imidazoline receptor agonist, like moxonidine and rilmenidine.