:Trimethylamine-corrinoid protein Co-methyltransferase

{{Infobox enzyme

| Name = Trimethylamine-corrinoid protein Co-methyltransferase

| EC_number = 2.1.1.250

| CAS_number =

| GO_code =

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Trimethylamine-corrinoid protein Co-methyltransferase ({{EC number|2.1.1.250}}, mttB (gene), trimethylamine methyltransferase) is an enzyme with systematic name trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.{{cite journal | vauthors = Ferguson DJ, Krzycki JA | title = Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri | journal = Journal of Bacteriology | volume = 179 | issue = 3 | pages = 846–52 | date = February 1997 | pmid = 9006042 | pmc = 178769 | doi = 10.1128/jb.179.3.846-852.1997 }}{{cite journal | vauthors = Krzycki JA | title = Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases | journal = Current Opinion in Chemical Biology | volume = 8 | issue = 5 | pages = 484–91 | date = October 2004 | pmid = 15450490 | doi = 10.1016/j.cbpa.2004.08.012 }} This enzyme catalyses the following chemical reaction

: trimethylamine + [Co(I) trimethylamine-specific corrinoid protein] $\backslash rightleftharpoons$ [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

This enzyme is involved in methanogenesis from trimethylamine.