:User:Pgnick/sandbox

Prilosec OTC is the first over-the-counter Proton Pump Inhibitor (PPI) to come on the market.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Prilosec OTC (omeprazole) Information |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/prilosec-otc-omeprazole-information#:~:text=The%20Food%20and%20Drug%20Administration,counter%20treatment%20for%20frequent%20heartburn |journal=FDA |language=en}} Prilosec OTC can be found in most drug and food retailers and has been awarded as the #1 DOCTOR AND GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for over 15 straight years.{{Cite web |title=Prilosec OTC - Frequent Heartburn Relief Medicine |url=https://prilosecotc.com/en-us |access-date=2025-05-16 |website=prilosecotc.com |language=en-US}} The brand is owned by [https://us.pg.com/ Procter & Gamble] in alliance with AstraZeneca.{{Cite web |title=AstraZeneca/P&G's Prilosec OTC cleared by FDA for frequent heartburn |url=https://www.thepharmaletter.com/astrazeneca-p-g-s-prilosec-otc-cleared-by-fda-for-frequent-heartburn |access-date=2025-05-16 |website=www.thepharmaletter.com |language=en}} Prilosec OTC is specially formulated to treat frequent heartburn, which can be brought on by certain foods, stress, smoking and other factors.{{Cite web |title=Prilosec Uses, Dosage & Side Effects |url=https://www.drugs.com/prilosec.html |access-date=2025-05-16 |website=Drugs.com |language=en}}

{{Infobox company

| name = PrilosecOTC

| industry = Over-the-counter medicines

| parent = Procter & Gamble

| website = https://prilosecotc.com/en-us

}}

History

Prilosec was first sold in 1989 as an FDA approved prescription medication for severe heartburn.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Questions and Answers on Prilosec OTC (omeprazole) |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole#:~:text=FDA%20originally%20approved%20prescription%20Prilosec%20in%201989 |journal=FDA |language=en}} In 2003, Prilosec OTC was introduced to the market as the first over-the-counter treatment for frequent heartburn.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Prilosec OTC (omeprazole) Information |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/prilosec-otc-omeprazole-information#:~:text=The%20Food%20and%20Drug%20Administration,counter%20treatment%20for%20frequent%20heartburn |journal=FDA |language=en}}

Uses  

Prilosec OTC is meant for those who experience painful heartburn episodes 2 or more times a week. It protects against heartburn by blocking it before it starts, providing 24-hour relief from frequent heartburn possible.  Taking one pill each morning prevents excess acid production, blocking heartburn all day and all night.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Questions and Answers on Prilosec OTC (omeprazole) |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole#:~:text=FDA%20originally%20approved%20prescription%20Prilosec%20in%201989 |journal=FDA |language=en}} It takes between 1-4 days for the full effects of Prilosec OTC to be felt, though some might feel complete relief in as soon as 24 hours. One course consists of taking 1 pill each morning for 14 consecutive days. For Prilosec OTC, you are directed to not take more than 14 days or more often than every 4 months unless directed by a doctor.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Questions and Answers on Prilosec OTC (omeprazole) |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole#:~:text=FDA%20originally%20approved%20prescription%20Prilosec%20in%201989 |journal=FDA |language=en}} The brand is sold in two varieties, one unflavored and the other with a wildberry flavor.{{Cite web |title=Prilosec OTC - Frequent Heartburn Relief Medicine |url=https://prilosecotc.com/en-us |access-date=2025-05-16 |website=prilosecotc.com |language=en-US}}

Main ingredients  

The active ingredient in Prilosec OTC is delayed release omeprazole which is in the drug class proton pump inhibitors or PPIs. The “proton pumps” are present in parietal cells in the stomach and responsible for stomach acid production. There are 3 pathways the body uses to tell these cells to produce more stomach acid. Prilosec OTC prevents excess stomach acid production by turning off these acid producing pumps, and blocking heartburn before it starts. The benefits of Prilosec OTC last for up to 24 hours while the stomach makes new acid pumps. While proton pump inhibitors like Prilosec OTC start working on the first day, it can take up to 4 days for some people to see the full benefits.{{Cite journal |last1=McRorie Jr. |first1=Johnson W. |last2=Gibb |first2=Roger D. |last3=Miner Jr. |first3=Philip B. |date=2014 |title=Evidence-based treatment of frequent heartburn: The benefits and limitations of over-the-counter medications |url=https://onlinelibrary.wiley.com/doi/abs/10.1002/2327-6924.12133 |journal=Journal of the American Association of Nurse Practitioners |language=en |volume=26 |issue=6 |pages=330–339 |doi=10.1002/2327-6924.12133 |pmid=24825071 |issn=2327-6924}} Other common treatment options for heartburn are antacids and histamine receptor agonists (H2RA’s).  Antacids are products that show up on the pH scale as basic and work to neutralize the stomach acid through an acid-base reaction, their effects can last for up to a few hours.  H2RA’s work by blocking the histamine receptor on the cells that produce stomach acid, so that the body can’t use that pathway to increase stomach acid.{{Cite web |title=Take the "Burn" out of Heartburn |url=https://pharmacist.therapeuticresearch.com/Content/Segments/PRL/2016/Aug/Take-the-Burn-out-of-Heartburn-10028 |access-date=2025-05-16 |website=pharmacist.therapeuticresearch.com}} {{Cite journal |last1=McRorie Jr. |first1=Johnson W. |last2=Gibb |first2=Roger D. |last3=Miner Jr. |first3=Philip B. |date=2014 |title=Evidence-based treatment of frequent heartburn: The benefits and limitations of over-the-counter medications |url=https://onlinelibrary.wiley.com/doi/abs/10.1002/2327-6924.12133 |journal=Journal of the American Association of Nurse Practitioners |language=en |volume=26 |issue=6 |pages=330–339 |doi=10.1002/2327-6924.12133 |pmid=24825071 |issn=2327-6924}}However, the H2RA’s do not affect the other 2 pathways the body has for turning on the acid pumps.   Over the counter antacids can be used multiple times throughout the day as needed to treat heartburn while the H2RA’s can be used up to twice daily.{{Cite journal |last1=McRorie Jr. |first1=Johnson W. |last2=Gibb |first2=Roger D. |last3=Miner Jr. |first3=Philip B. |date=2014 |title=Evidence-based treatment of frequent heartburn: The benefits and limitations of over-the-counter medications |url=https://onlinelibrary.wiley.com/doi/abs/10.1002/2327-6924.12133 |journal=Journal of the American Association of Nurse Practitioners |language=en |volume=26 |issue=6 |pages=330–339 |doi=10.1002/2327-6924.12133 |pmid=24825071 |issn=2327-6924}}

Advertising and media  

Prilosec OTC is recognizable for its 2010s campaign with Larry the Cable Guy as the brand’s “Zero Heartburn” spokesperson.{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2018-11-03 |title=Questions and Answers on Prilosec OTC (omeprazole) |url=https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole#:~:text=in%20the%20body.-,6.%20If%20Prilosec%20OTC%20takes%20a%20few%20days%20to%20take%20effect,to%20take%20more%20than%201%20course%20of%20treatment%20every%204%20months,-7.%20Who%20should |journal=FDA |language=en}}