:X-linked hypertrichosis
{{Short description|Chromosomal disorder}}
{{Infobox medical condition (new)
| name =
| synonym = X-linked congenital generalized hypertrichosis
| image = X-linked dominant.svg
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| alt = X-linked dominant inheritance scenarios for either the mother or father being affected
| caption = X-linked hypertrichosis is an X-linked dominant disorder.
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| specialty = Dermatology
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X-linked hypertrichosis, also known as X-linked congenital generalized hypertrichosis, is a hereditary disorders characterized by generalized congenital hypertrichosis and thick eyebrows.{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages=1008 |isbn=978-1-4160-2999-1 }}
Signs and symptoms
Hypertrichosis is characterized as excessive hair growth anywhere on the body, in either men or women.{{cite web | last1=Saleh | first1=Dahlia | last2=Yarrarapu | first2=Siva Naga S. | last3=Cook | first3=Christopher | title=Hypertrichosis | publisher=StatPearls Publishing | date=2023-08-16 | pmid=30521275 | url=https://www.ncbi.nlm.nih.gov/books/NBK534854/ | access-date=2024-04-27}} X-linked hypertrichosis affects males more than females.{{cite journal | last1=Macías-Flores | first1=M. A. | last2=García-Cruz | first2=D. | last3=Rivera | first3=H. | last4=Escobar-Luján | first4=M. | last5=Melendrez-Vega | first5=A. | last6=Rivas-Campos | first6=D. | last7=Rodríguez-Collazo | first7=F. | last8=Moreno-Arellano | first8=I. | last9=Cantu | first9=J. M. | title=A new form of hypertrichosis inherited as an X-linked dominant trait | journal=Human Genetics | volume=66 | issue=1 | date=1984 | issn=0340-6717 | doi=10.1007/BF00275189 | pages=66–70}}
Causes
X-linked hypertrichosis was first mapped in chromosome Xq24-q27.1 in a Mexican family; however, the underlying genetic facts remain unknown.{{Cite journal|last1=Zhu|first1=Hongwen|last2=Shang|first2=Dandan|last3=Sun|first3=Miao|last4=Choi|first4=Sunju|last5=Liu|first5=Qing|last6=Hao|first6=Jiajie|last7=Figuera|first7=Luis E.|last8=Zhang|first8=Feng|last9=Choy|first9=Kwong Wai|last10=Ao|first10=Yang|last11=Liu|first11=Yang|date=2011-06-10|title=X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3|journal=American Journal of Human Genetics|volume=88|issue=6|pages=819–826|doi=10.1016/j.ajhg.2011.05.004|issn=0002-9297|pmc=3113246|pmid=21636067}} X-linked hypertrichosis is inherited in an X-linked dominant pattern of inheritance.
See also
Further reading
- {{cite journal | last1=DeStefano | first1=Gina M. | last2=Fantauzzo | first2=Katherine A. | last3=Petukhova | first3=Lynn | last4=Kurban | first4=Mazen | last5=Tadin-Strapps | first5=Marija | last6=Levy | first6=Brynn | last7=Warburton | first7=Dorothy | last8=Cirulli | first8=Elizabeth T. | last9=Han | first9=Yujun | last10=Sun | first10=Xiaoyun | last11=Shen | first11=Yufeng | last12=Shirazi | first12=Maryam | last13=Jobanputra | first13=Vaidehi | last14=Cepeda-Valdes | first14=Rodrigo | last15=Cesar Salas-Alanis | first15=Julio | last16=Christiano | first16=Angela M. | title=Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis | journal=Proceedings of the National Academy of Sciences | volume=110 | issue=19 | date=2013-05-07 | issn=0027-8424 | pmid=23603273 | pmc=3651487 | doi=10.1073/pnas.1216412110 | pages=7790–7795 | doi-access=free | ref=none}}
- {{cite journal | last1=Figuera | first1=Luis E. | last2=Pandolfo | first2=Massimo | last3=Dunne | first3=Patrick W. | last4=Cantú | first4=Jose M. | last5=Patel | first5=Pragna I. | title=Mapping of the congenital generalized hypertrichosis locus to chromosome Xq24–q27.1 | journal=Nature Genetics | publisher=Springer Science and Business Media LLC | volume=10 | issue=2 | year=1995 | issn=1061-4036 | doi=10.1038/ng0695-202 | pages=202–207 | pmid=7663516 | ref=none}}
External links
{{Medical resources
| ICD11 = {{ICD11|LD27.0Y}}
| ICD10 = {{ICD10|Q84.2}}
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| OMIM = 307150
| MeshID = C538388
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| SNOMED CT = 1010628009
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| GARDNum = 2863
| GARDName = X-linked congenital generalized hypertrichosis
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| Orphanet = 79495
| Scholia = Q8041556
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