:en:MedImmune
{{Short description|Biopharmaceutical company, acquired by AstraZeneca in 2007}}
{{Infobox company
| name = MedImmune, LLC
| logo = MedImmune_logo.svg
| type = Subsidiary
| parent = AstraZeneca
| genre =
| fate =
| predecessor =
| successor =
| foundation = {{ubl
|{{start date and age|1988}} (as Molecular Vaccines, Inc.)
|{{start date and age|1989}} (as MedImmune, Inc.)
}}
| founder =
| defunct =
| location_city =
| location_country =
| location = Gaithersburg, Maryland, U.S.
| locations =
| area_served =
| key_people =
| industry = Pharmaceutical
| products = {{ubl
}}
| production =
| services =
| revenue =
| operating_income =
| net_income =
| aum =
| assets =
| equity =
| owner =
| num_employees =
| divisions =
| subsid =
| homepage = [https://web.archive.org/web/19961229200313/http://www.medimmune.com/ www.medimmune.com]
| footnotes =
| intl =
}}
MedImmune, LLC was a wholly owned subsidiary of AstraZeneca before February 14, 2019, when it was announced that the MedImmune name and branding would be discontinued in favor of AstraZeneca.{{Cite web|url=http://www.evaluate.com/vantage/articles/news/corporate-strategy/12-years-astra-draws-line-under-medimmune|title=12 years on, Astra draws a line under Medimmune|date=2019-02-14|website=Evaluate.com|language=en|access-date=2019-02-15}}{{Cite web|url=https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/|title=AstraZeneca retires Medimmune name amid sales turnaround|website=BioPharma Dive|language=en-US|access-date=2019-02-16}}
MedImmune was founded in 1988 as Molecular Vaccines, Inc, and was purchased in 2007 for $15.6 billion.{{cite web|url=https://www.nytimes.com/2007/04/24/business/24drug-web.html|title=AstraZeneca Buys MedImmune for $15.6 Billion|first=Andrew|last=Pollack|work=The New York Times |date=24 April 2007|access-date=2 June 2019|via=NYTimes.com}} Its main offices were located in Gaithersburg, MD, Cambridge, UK, and Mountain View, CA.{{Cite web |url=https://www.medimmune.com/about-us.html |title=About Us | MedImmune |access-date=2017-08-23 |archive-url=https://web.archive.org/web/20170830152939/https://www.medimmune.com/about-us.html |archive-date=2017-08-30 |url-status=dead }}
It produced Synagis, a drug for the prevention of respiratory infections in infants, which accounted for US$ 1.06 billion of its US$ 1.2 billion in revenue for 2005, and FluMist, a nasal spray influenza vaccine introduced in 2004. MedImmune acquired FluMist when it purchased Aviron in 2002 for US$ 1.5 billion. FluMist sales totaled US$ 104 million in 2008, US$ 54.8 million in 2007, and US$ 36.4 million in 2006.{{cite news
| url=https://www.washingtonpost.com/wp-dyn/content/article/2009/06/01/AR2009060101608.html
| title=MedImmune Wins Key Contract To Develop Swine Flu Vaccine
| author=Michael S. Rosenwald
| date=June 2, 2009
| access-date=October 23, 2009
| newspaper=The Washington Post
}}
FluMist was approved for children two years of age and older in 2007, but initially was approved only for healthy people ages 5 to 49, a significant limitation because it eliminated a significant market—young children who find injections objectionable. Sales of FluMist fell short of analysts' expectations for the first two years the drug was sold. FluMist was initially sold in a frozen form, which was difficult for doctors to store.
- [http://www.medimmune.com Medimmune Company Site]
- [http://www.flumist.com Flumist nasal flu vaccine - Official website]
- Bishop, Tricia. "MedImmune loss in '05 quadruples shortfall from '04" Baltimore Sun. 3 February 2006.
- Rosenwald, Michael S. "[https://www.washingtonpost.com/wp-dyn/content/article/2006/02/02/AR2006020202320.html Sales of MedImmune's Flu Vaccine Drop Sharply]" Washington Post. 3 February 2006.
MedImmune conducted successful clinical trials for a new generation of FluMist needle-free vaccine, called CAIV-T, which was approved by the U.S. Food and Drug Administration (FDA) in 2007, and is now the form offered on the market.
History
Molecular Vaccines, Inc. was founded by Wayne T. Hockmeyer, David Mott, and Dr. James Young in 1988. In 1989, Molecular Vaccines, Inc changed its name to MedImmune, Inc.
On April 23, 2007, it was announced MedImmune and AstraZeneca entered into a definitive agreement under which AstraZeneca intended to acquire MedImmune in an all-cash transaction at US$ 58 per share, or about US$ 15.2 billion. On 19 June 2007 AstraZeneca completed the acquisition paying US$ 15.2 billion primarily for its drug development pipeline. Analysts have criticised the take-over, claiming that AstraZeneca paid too much.{{cite web|url=https://money.cnn.com/2007/04/23/news/companies/astrazeneca/index.htm|title=AstraZeneca's $15 Billion Buy of MedImmune buy too costly, some say|website=Money.cnn.com|access-date=2 June 2019}} AstraZeneca chose to merge MedImmune with Cambridge Antibody Technology, which it had acquired in 2006, creating a new biologics division under the MedImmune name. AstraZeneca presented the new MedImmune to investors on 7 December 2007.{{cite web|url=https://www.astrazeneca.com/media-centre.html|title=Media Centre - AstraZeneca|website=Astrazeneca.com|access-date=2 June 2019}}
In June 2007, the National Institutes of Health (NIH) began enrolling participants in a Phase 1 H5N1 study of an intranasal influenza vaccine candidate based on MedImmune's live, attenuated vaccine technology.[https://archive.today/20120720193549/http://phx.corporate-ir.net/phoenix.zhtml?c=83037&p=irol-newsArticle_Print&ID=872852&highlight= MedImmune] Press release MedImmune and National Institutes of Health Begin Clinical Testing of a Live, Attenuated Intranasal Vaccine Against an H5N1 Avian Influenza Virus published June 15, 2007
MedImmune said it was making a significant, rapid response with a vaccine to the novel H1N1 variant of influenza, known as swine flu.{{cite web
|url = http://www.medimmune.com/h1n1.aspx
|title = MedImmune Influenza A (H1N1) Information
|access-date = October 23, 2009
|url-status = dead
|archive-url = https://web.archive.org/web/20090924184207/http://www.medimmune.com/h1n1.aspx
|archive-date = September 24, 2009
}} In June 2009 it won a Department of Health and Human Services (HHS) contract, worth $90m. Under the contract with HHS, MedImmune will continue to make its seasonal FluMist vaccine and also develop a vaccine targeted specifically at the novel H1N1 virus. MedImmune then won a second contract to test its nasal spray flu technology as a viable treatment for the H1N1.{{cite news| url=http://www.bizjournals.com/washington/stories/2009/07/13/daily21.html | first=Vandana | last=Sinha | title=MedImmune gets second H1N1 flu contract | date=13 July 2009}}
MedImmune received approval from the U.S. FDA for its intranasal novel H1N1 influenza vaccine in September 2009.
Pipeline
MedImmune had over 120 drugs in development for conditions including lupus, COPD, asthma, and many types of cancer. Major phase III trials included:{{cite web|url=https://www.astrazeneca.com/our-science/pipeline.html|title=Pipeline - AstraZeneca|website=Astrazeneca.com|access-date=2 June 2019}}
- durvalumab (anti-PD-L1)
- tremelimumab (anti-CTLA-4)
- moxetumomab pasudotox (anti-CD22)
- benralizumab (anti-IL-5R)
- tralokinumab (anti-IL-13)
- anifrolumab (anti-IFN-aR)
- nirsevimab (anti-RSV)
See also
References and notes
{{Reflist}}
External links
{{Commons category|MedImmune}}
- [http://www.flumist.com/ Flumist nasal flu vaccine - Official website]
{{AstraZeneca}}
{{Pharmaceutical industry in the United Kingdom}}
{{Authority control}}
{{DEFAULTSORT:Medimmune}}
Category:Companies based in Gaithersburg, Maryland
Category:Biotechnology companies of the United States
Category:Health care companies based in Maryland
Category:Biotechnology companies established in 1988
Category:Pharmaceutical companies established in 1988