Β-Neoendorphin

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{{Chembox

| Name=β-Neoendorphin

| ImageFile = Beta-neoendorphin.svg

| ImageSize = 250px

| ImageAlt =

| IUPACName =

| OtherNames = Beta-Neoendorphin

|Section1={{Chembox Identifiers

| CASNo = 77739-21-0

| SMILES = N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O

| PubChem = 122260

| IUPHAR_ligand = 1644

| ChemSpiderID = 109029

| InChI = 1/C54H77N13O12/c1-32(2)26-41(65-51(76)42(28-33-10-4-3-5-11-33)62-46(71)31-60-45(70)30-61-47(72)38(56)27-34-15-19-36(68)20-16-34)50(75)64-40(13-8-24-59-54(57)58)48(73)63-39(12-6-7-23-55)49(74)66-43(29-35-17-21-37(69)22-18-35)52(77)67-25-9-14-44(67)53(78)79/h3-5,10-11,15-22,32,38-44,68-69H,6-9,12-14,23-31,55-56H2,1-2H3,(H,60,70)(H,61,72)(H,62,71)(H,63,73)(H,64,75)(H,65,76)(H,66,74)(H,78,79)(H4,57,58,59)/t38-,39-,40-,41-,42-,43-,44-/m0/s1

| InChIKey = RTXIYIQLESPXIV-VLOLPVCOBE

| StdInChI = 1S/C54H77N13O12/c1-32(2)26-41(65-51(76)42(28-33-10-4-3-5-11-33)62-46(71)31-60-45(70)30-61-47(72)38(56)27-34-15-19-36(68)20-16-34)50(75)64-40(13-8-24-59-54(57)58)48(73)63-39(12-6-7-23-55)49(74)66-43(29-35-17-21-37(69)22-18-35)52(77)67-25-9-14-44(67)53(78)79/h3-5,10-11,15-22,32,38-44,68-69H,6-9,12-14,23-31,55-56H2,1-2H3,(H,60,70)(H,61,72)(H,62,71)(H,63,73)(H,64,75)(H,65,76)(H,66,74)(H,78,79)(H4,57,58,59)/t38-,39-,40-,41-,42-,43-,44-/m0/s1

| StdInChIKey = RTXIYIQLESPXIV-VLOLPVCOSA-N}}

|Section2={{Chembox Properties

| C=54 | H=77 | N=13 | O=12

| Appearance =

| Density =

| MeltingPt =

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|Section3={{Chembox Hazards

| MainHazards =

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β-Neoendorphin is an endogenous opioid peptide with a nonapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro (YGGFLRKYP).{{cite journal | doi = 10.1016/0006-291X(81)91243-2 |author1=Minamino N. |author2=Kangawa K. |author3=Chino N. | title = β-Neo-endorphin, a new hypothalamic 'big' leu-enkephalin of porcine origin: Its purification and the complete amino acid sequence | year = 1981 | journal = Biochemical and Biophysical Research Communications | volume = 99 | issue = 3 | pages = 864–870 | pmid = 7247945}}

β-Neoendorphins (β-NEP) have the capability to stimulate wound healing by accelerating keratinocyte migration. This is achieved by β-NEP's activation of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases 1 and 2 (ERK 1 and ERK 2); along with the upregulation of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9). Wound healing by β-NEP results in migration without consequences on proliferation in human keratinocytes.{{Cite journal |last1=Yang |first1=Dong Joo |last2=Moh |first2=Sang Hyun |last3=Choi |first3=Yun-Hee |last4=Kim |first4=Ki Woo |date=2020-10-12 |title=β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte |journal=Molecules |volume=25 |issue=20 |pages=4640 |doi=10.3390/molecules25204640 |issn=1420-3049 |pmid=33053781|pmc=7587199 |doi-access=free }}