1,2-Dichloropropane

{{distinguish|1,3-dichloropropane}}

{{Chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 477203682

| Reference =[http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO|BRAND_KEY&N4=D72182|ALDRICH&N25=0&QS=ON&F=SPEC 1,2-Dichloropropane] at Sigma-Aldrich

| ImageFile = 1,2-dichloropropane skeletal.png

| ImageSize = 150px

| ImageAlt =

| PIN = 1,2-Dichloropropane

| OtherNames = Propylene dichloride, Propane, 1,2-dichloro-

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 6316

| InChI = 1/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3

| InChIKey = KNKRKFALVUDBJE-UHFFFAOYAR

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 44641

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = KNKRKFALVUDBJE-UHFFFAOYSA-N

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo = 78-87-5

| PubChem = 6564

| ChEBI = 82163

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = C19034

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = RRZ023OFWL

| EC_number = 201-152-2

| RTECS = TX9625000

| UNNumber = 1279

| SMILES = ClCC(Cl)C

}}

|Section2={{Chembox Properties

| C=3 | H=6 | Cl=2

| Appearance = Colorless liquid

| Odor = like chloroform

| Density = 1.156 g/cm{{sup|3}}

| MeltingPtC = −100

| BoilingPtC = 95 to 96

| Solubility = 0.26 g/100 mL (at 20 °C)

| VaporPressure = 40 mmHg (20°C)

}}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPtC = 16

| AutoignitionPtC = 557

| GHSPictograms = {{GHS07}}{{GHS08}}

| GHSSignalWord = Danger

| HPhrases = {{H-phrases|225|302|332|350}}

| PPhrases = {{P-phrases|201|202|210|233|240|241|242|243|261|264|270|271|280|281|301+312|303+361+353|304+312|304+340|308+313|312|330|370+378|403+235|405|501}}

| NFPA-H = 2

| NFPA-F = 3

| NFPA-R = 0

| PEL = TWA 75 ppm (350 mg/m{{sup|3}}){{PGCH|0534}}

| ExploLimits = 3.4%-14.5%

| IDLH = Ca [400 ppm]

| REL = Ca

| LC50 = 2000 ppm (rat, 4 hr)
720 ppm (mouse, 10 hr)
2980 ppm (rat, 8 hr){{IDLH|78875|Propylene dichloride}}

| LD50 = 860 mg/kg (mouse, oral)
1947 mg/kg (rat, oral)
2000 mg/kg (guinea pig, oral)

}}

}}

1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.Manfred Rossberg, Wilhelm Lendle, Gerhard Pfleiderer, Adolf Tögel, Eberhard-Ludwig Dreher, Ernst Langer, Heinz Rassaerts, Peter Kleinschmidt, Heinz Strack, Richard Cook, Uwe Beck, Karl-August Lipper, Theodore R. Torkelson, Eckhard Löser, Klaus K. Beutel, Trevor Mann "Chlorinated Hydrocarbons" in Ullmann's Encyclopedia of Industrial Chemistry 2006, Wiley-VCH, Weinheim. {{doi|10.1002/14356007.a06_233.pub2}}.

Uses

1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals. It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.{{Cite web |url=https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=830&toxid=162 |title=ToxFAQs for 1,2-Dichloropropane |access-date=2010-06-16 }}

Carcinogenity

Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.[http://www.mhlw.go.jp/stf/houdou/2r9852000002x6at.html Report by the Japanese Ministry of Health, Labour and Welfare][http://www.yomiuri.co.jp/national/news/20130314-OYT1T00708.htm Article] in the Yomiuri Shimbun

Data from animal studies show tumor growth in the liver and mammary glands.[https://www.cdc.gov/niosh/npg/npgd0534.html CDC - NIOSH Pocket Guide to Chemical Hazards] Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.[https://www.cdc.gov/niosh/idlh/78875.html Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)]

References