1-(2-Diphenyl)piperazine

{{Short description|Chemical compound}}

{{Drugbox

| verifiedrevid = 456495470

| IUPAC_name = 1-(2-diphenyl)piperazine

| image = 1-(2-diphenyl)piperazine.svg

| width = 220

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 2019031

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C16H18N2/c1-2-6-14(7-3-1)15-8-4-5-9-16(15)18-12-10-17-11-13-18/h1-9,17H,10-13H2

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = RKRVRTJVCWZOQS-UHFFFAOYSA-N

| tradename =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US =

| legal_status =

| routes_of_administration =

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|correct|CAS}}

| CAS_number = 180698-18-4

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = T5S5265H6V

| ATC_prefix =

| ATC_suffix =

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 494675

| PubChem = 2737389

| C=16 | H=18 | N=2

| smiles = C3CNCCN3c1ccccc1-c2ccccc2

}}

1-(2-Diphenyl)piperazine, also known as RA-7, is a drug that acts as a potent and selective antagonist at the 5-HT7 receptor serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT{{sub|7}} agonists LP-12 and LP-211 and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.{{cite journal |vauthors=Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R |title=LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor |journal=Neuroscience Letters |volume=481 |issue=1 |pages=12–6 |pmid=20600619 |pmc=2910240 |doi=10.1016/j.neulet.2010.06.036 |date=August 2010}}