1-Indanone
{{Chembox
| ImageFile = 1-indanon.png
| ImageSize = 148 px
| ImageAlt =
| PIN = 2,3-Dihydro-1H-inden-1-one
| OtherNames = α-Hydroindone
|Section1={{Chembox Identifiers
| CASNo = 83-33-0
| PubChem = 6735
| ChemSpiderID = 6479
| EC_number = 201-470-1
| UNII = V7021Y717I
| KEGG = C01504
| Gmelin = 142414
| Beilstein = 507957
| 3DMet = B00309
| ChEBI = 17404
| StdInChI=1S/C9H8O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4H,5-6H2
| StdInChIKey = QNXSIUBBGPHDDE-UHFFFAOYSA-N
| SMILES = C1CC(=O)C2=CC=CC=C21
}}
|Section2={{Chembox Properties
| C=9|H=8|O=1
| Appearance = Colorless solid
| Density =
| MeltingPtC = 38-42
| BoilingPtC = 243-245
| Solubility = }}
|Section3={{Chembox Hazards
| GHSPictograms = {{GHS07}}
| GHSSignalWord = Warning
| HPhrases = {{H-phrases|302}}
| PPhrases = {{P-phrases|261|264|270|271|280|301+312|302+352|304+340|305+351+338|312|321|330|332+313|337+313|362|403+233|405|501}}
| MainHazards =
| FlashPt =
| AutoignitionPt = }}
}}
1-Indanone is the organic compound with the formula C6H4(CH2)2CO. It is one of two isomeric benzocyclopentanones, the other being 2-indanone. It is a colorless solid. 1-Indanone is a substrate for the enzyme indanol dehydrogenase.
Preparation
It is prepared by oxidation of indane or indene.{{cite journal|title=α-Hydroindone|author=
R. A. Pacaud, C. F. H. Allen|journal=Org. Synth.|year=1938|volume=18|pages=47|doi=10.15227/orgsyn.018.0047}} It can also be prepared by cyclization of phenylpropionic acid.
Uses
1-Indanone is an intermediate in the synthesis of a variety of pharmaceutical drugs including 2-aminoindane (using beta-keto-oxime formation with isoamylnitrite followed by reduction), drinidene, pirandamine,I. Jirkovsky, L. G. Humber and R. Noureldin, Eur. J. Med. Chem., 11, 571 (1976) and pyrophendane.