1948 Challenge Desgrange-Colombo

{{ Infobox cycling season

| name = 1948 Challenge Desgrange-Colombo

| edition = 1

| competition = Challenge Desgrange-Colombo

| image =

| image_caption =

| image_alt =

| image_size =

| dates = 19 March – 24 October

| location = Europe

| rounds = 9

| individual_champion = {{flagathlete|Briek Schotte|BEL}}

| individual_champion_team = Alcyon–Dunlop

| nations_champion = {{ITA}}

| previous =

| next = 1949

}}

The 1948 Challenge Desgrange-Colombo was the first edition of the Challenge Desgrange-Colombo. It included nine races - seven one-day races and two stage races - all in Belgium, France or Italy.