1950 Challenge Desgrange-Colombo

{{ Infobox cycling season

| name = 1950 Challenge Desgrange-Colombo

| edition = 3

| competition = Challenge Desgrange-Colombo

| image =

| image_caption =

| image_alt =

| image_size =

| dates = 18 March – 22 October

| location = Europe

| rounds = 10

| individual_champion = {{flagathlete|Ferdinand Kübler|SUI}}

| individual_champion_team = Fréjus

| nations_champion = {{flagu|Italy}}

| previous = 1949

| next = 1951

}}

The 1950 Challenge Desgrange-Colombo was the third edition of the Challenge Desgrange-Colombo. It included ten races: all the races form the 1949 edition were retained with no additions.