1958 Challenge Desgrange-Colombo

{{ Infobox cycling season

| name = 1958 Challenge Desgrange-Colombo

| edition = 11

| competition = Challenge Desgrange-Colombo

| image =

| image_caption =

| image_alt =

| image_size =

| dates = 19 March – 19 October

| location = Europe

| rounds = 12

| individual_champion = {{flagathlete|Fred De Bruyne|BEL}}

| individual_champion_team = {{UCI team code|Carpano|1958}}

| nations_champion = {{BEL}}

| previous = 1957

| next = 1959 (Super Prestige Pernod)

}}

The 1958 Challenge Desgrange-Colombo was the eleventh and final edition of the Challenge Desgrange-Colombo. It included eleven races: all the races form the 1957 edition were retained and the Vuelta a España was included for the first time. Fred De Bruyne won the third of his three individual championships while Belgium retained the nations championship. The Challenge Desgrange-Colombo folded after the 1958 season and the Super Prestige Pernod replaced it as the season-long competition for road bicycle racing.