2-Hexanone
{{chembox
| verifiedrevid = 415525032
| Name = 2-Hexanone
| ImageFile = 2-Hexanone.png
| ImageSize = 150px
| ImageName = Skeletal formula of hexan-2-one
| ImageFile1 = 2-Hexanone-3D-balls.png
| ImageSize1 = 180px
| ImageName1 = Ball-and-stick model of hexan-2-one
| PIN = Hexan-2-one
| OtherNames = Methyl butyl ketone; Methyl n-butyl ketone; MNBK; Butyl methyl ketone; MBK; n-Butyl methyl ketone; Propylacetone
| Reference=Merck Index, 11th Edition, 5955.CRC Handbook of Chemistry and Physics, 75th ed. (1995)
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 11095
| InChI = 1/C6H12O/c1-3-4-5-6(2)7/h3-5H2,1-2H3
| InChIKey = QQZOPKMRPOGIEB-UHFFFAOYAQ
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 195861
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C6H12O/c1-3-4-5-6(2)7/h3-5H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QQZOPKMRPOGIEB-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 591-78-6
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6QDY60NH6N
| EINECS = 209-731-1
| PubChem = 11583
| SMILES = O=C(C)CCCC
| RTECS = MP1400000
}}
| Section2 = {{Chembox Properties
| C=6|H=12|O=1
| Appearance = Colorless to light yellow liquid
| Odor = sharp, acetone-like
| Density = 0.8113 g/cm3
| Solubility = 1.4% (14 g/L)
| Solvent = water, acetone, ethanol, ethyl ether
| RefractIndex = 1.403 (20 °C)
| Viscosity = 0.63 mPa·s (20 °C)
| VaporPressure = 1.3 kPa (20 °C)
| MeltingPtC = -55.5
| BoilingPtC = 127.6
| MagSus = −69.1·10−6 cm3/mol
}}
| Section7 = {{Chembox Hazards
| GHSPictograms = {{GHS02}}{{GHS07}}{{GHS08}}
| GHSSignalWord= Danger
| HPhrases = {{H-phrases|226|336|361f|372|}}
| PPhrases = {{P-phrases|201|202|210|233|240|241|242|243|260|261|264|270|271|280|281|303+361+353|304+340|308+313|312|314|370+378|403+233|403+235|405|501|}}
| NFPA-H = 2
| NFPA-F = 3
| NFPA-R = 0
| FlashPtC = 25
| AutoignitionPtC = 423
| LD50 = 2590 mg/kg (oral, rat)
2430 mg/kg (oral, mouse)
4860 mg/kg (dermal, rabbit)
2590 mg/kg (oral, guinea pig)
| PEL = TWA 100 ppm (410 mg/m3)
| IDLH = 1600 ppm{{PGCH|0325}}
| LC50 = 8000 ppm (rat, 4 hr){{IDLH|591786|2-Hexanone}}
| LCLo = 20,000 ppm (guinea pig, 70 min)
| LDLo = 914 mg/kg (rat, oral)
}}
}}
2-Hexanone (methyl butyl ketone, MBK) is a ketone used as a general solvent and in paints. It dissolves cellulose nitrate, vinyl polymers and copolymers, and natural and synthetic resins. It is recommended as a solvent because it is photochemically inactive;{{citation | author=Dieter Stoye | contribution=Solvents | title=Ullmann's Encyclopedia of Industrial Chemistry | edition=7th | publisher=Wiley | year=2007 | page=56}} however it has a very low safe threshold limit value. 2-Hexanone is absorbed through the lungs, orally and dermally and its metabolite, 2,5-hexanedione, is neurotoxic.{{citation | author=Jerrold B. Leikin | author2=Frank P. Paloucek | contribution=2-Hexanone | title=Poisoning and Toxicology Handbook | edition=4th | publisher=Informa | year=2008 | page=737}} Animal tests have shown that the neurotoxic effect of 2-hexanone may be potentiated by simultaneous administration of 2-butanone (methyl ethyl ketone, MEK).{{citation | author=Wilhelm Neier | author2=Günter Strehlke | contribution=2-Butanone | title=Ullmann's Encyclopedia of Industrial Chemistry | edition=7th | publisher=Wiley | year=2007 | page=6}}