2-hydroxyphytanoyl-CoA lyase

{{Short description|Class of enzymes}}

{{Infobox protein

|Name=2-hydroxyacyl-CoA lyase 1

|caption=

|image=

|width=

|HGNCid=17856

|Symbol=HACL1

|AltSymbols=HPCL

|EntrezGene=26061

|OMIM=604300

|RefSeq=NM_012260

|UniProt=Q9UJ83

|PDB=

|ECnumber=

|Chromosome=3

|Arm=p

|Band=24.3

|LocusSupplementaryData=

}}

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.{{cite journal |vauthors=Foulon V, Antonenkov V, Croes K |title=Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue=18 |pages=10039–44 |year=1999 |pmid=10468558 |doi=10.1073/pnas.96.18.10039 |pmc=17838|bibcode=1999PNAS...9610039F |display-authors=etal|doi-access=free }}

It is classified under EC number 4.1.

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