2010 Omloop Het Nieuwsblad

{{Infobox cycling race report

| name = 2010 Omloop Het Nieuwsblad

| image =

| image_caption =

| date = 27 February

| stages = 1

| distance = 204.4

| unit = km

| time = 5h 07' 15"

| speed =

| first = Juan Antonio Flecha

| first_nat = ESP

| first_natvar =

| first_team = {{UCI team code|SKY|2010}}

| second = Heinrich Haussler

| second_nat = GER

| second_natvar =

| second_team = {{UCI team code|CTT|2010}}

| third = Tyler Farrar

| third_nat = USA

| third_natvar =

| third_team = {{UCI team code|GRM|2010}}

| previous = 2009

| next = 2011

}}

The 2010 Omloop Het Nieuwsblad cycle race took place on 27 February 2010. It was the 65th edition of the international classic Omloop Het Nieuwsblad. The race was the first 1.HC event in the 2010 UCI World Ranking.