2010 Vuelta a Castilla y León

{{Infobox cycling race report

| name = 2010 Vuelta a Castilla y León

| image =

| image_caption =

| image_size =

| series = 2009–10 UCI Europe Tour

| race_no =

| series_no =

| date = 14 April  – 18 April

| stages = 5

| distance = 700.5{{cite web|url=http://www.bikeraceinfo.com/stageraces/Castilla-Leon/vuelta-a-castilla-y-leon.html|title=Vuelta a Castilla y León (2.1)|work=BikeRaceInfo|accessdate=18 February 2020}}

| unit = km

| time = 16h 56' 01"

| speed =

| first = Alberto Contador

| first_nat = ESP

| first_team = {{UCI team code|AST|2010}}

| first_color = granate

| second = Igor Antón

| second_nat = ESP

| second_team = {{UCI team code|EUS|2010}}

| third = Ezequiel Mosquera

| third_nat = ESP

| third_team = {{UCI team code|XAC|2010}}

| points = Theo Bos

| points_nat = NED

| points_team = {{UCI team code|CTT|2010}}

| mountains = Iban Mayoz

| mountains_nat = ESP

| mountains_team = {{UCI team code|FOT|2010}}

| combination = Alberto Contador

| combination_nat = ESP

| combination_team = {{UCI team code|AST|2010}}

| team = Team RadioShack

| team_nat = USA

| previous = 2009

| next = 2011

}}

The 2010 Vuelta a Castilla y León was the 25th running of the Vuelta a Castilla y León road cycling stage race, which started on 14 April and concluded on 18 April 2010. Normally the race would be run in March, however, this year the start was pushed back to mid-April. The race was won by Alberto Contador.