2016–17 Women's EHF Challenge Cup#Quarter-finals

• TH: Title holders

All draws held at the European Handball Federation headquarters in Vienna, Austria.

Teams listed first played the first leg at home. Bolded teams qualified into round 3.

{{TwoLegStart}}

{{TwoLegResult|DHB Rotweiss Thun|SUI|56–41|ASD Ariosta P. Ferrara|ITA|34–17|28–24}}

{{TwoLegResult|SSV Dornbirn Schoren|AUT|54–66|CS Madeira|POR|34–36|20–30}}

{{TwoLegResult|ŽRK Ilidža|BIH|39–70^a|Zagnosspor|TUR|23–33|16–37}}

{{TwoLegResult|ŽRK Kumanovo|MKD|57–77|Helvetia BM Alcobendas|ESP|17–23|15–31}}

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;Notes:

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Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into last 16.

{{TwoLegStart}}

{{TwoLegResult|UHC Müllner Bau Stockerau|AUT|37–61|Kram Start Elbląg|POL|17–28|20–33}}

{{TwoLegResult|LK Zug|SUI|85–24^a|Olympia HC|GBR|45–17|40–7}}

{{TwoLegResult|Ardesen GSK|TUR|58–47|ŽRK Danilovgrad|MNE|30–23|28–24}}

{{TwoLegResult|Virto/Quintus|NED|90–40^b|ŽRK Mira Prijedor|BIH|46–19|44–21}}

{{TwoLegResult|HIFK|FIN|33–71^c|Rocasa Gran Canaria ACE|ESP|12–39|21–32}}

{{TwoLegResult|Haukar|ISL|50–41^d|Jomi Salerno|ITA|23–19|27–22}}

{{TwoLegResult|H 65 Höör|SWE|51–46|Prosetecnisa Zuazo|ESP|31–25|20–21}}

{{TwoLegResult|HC Svilengrad-PU|BUL|39–53|HC Vardar SCJS|MKD|17–24|22–29}}

{{TwoLegResult|Fémina Visé|BEL|36–50^e|ABU Baku|AZE|16–26|20–24}}

{{TwoLegResult|DHC Sokol Poruba|CZE|65–19^f|HC Mamuli|GEO|34–12|31–7}}

{{TwoLegResult|ŽRK Mlinotest Ajdovščina|SLO|48–43^g|Zagnosspor|TUR|25–22|23–21}}

{{TwoLegResult|HC Karpaty|UKR|54–42^h|DHB Rotweiss Thun|SUI|34–25|20–17}}

{{TwoLegResult|CS Madeira|POR|45–69|HC Lokomotiva Zagreb|CRO|24–29|21–40}}

{{TwoLegResult|Maccabi Arazim Ramat Gan|ISR|59–59ⁱ|KHF Shqiponja|KOS|31–30|28–29}}

{{TwoLegResult|Helvetia BM Alcobendas|ESP|44–50|Colégio de Gaia|POR|25–21|19–29}}

{{TwoLegResult|HC Dnepryanka Kherson|UKR|40–63^j|Mecalia Atlético Guardés|ESP|22–33|18–30}}

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;Notes:

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{{col-end}}

Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into quarterfinals.

{{TwoLegStart}}

{{TwoLegResult|LK Zug|SUI|65–50^a|HC Karpaty|UKR|29–25|36–25}}

{{TwoLegResult|DHC Sokol Poruba|CZE|97–40|KHF Shqiponja|KOS|51–18|46–22}}

{{TwoLegResult|ABU Baku|AZE|47–65^b|Kram Start Elbląg|POL|23–33|24–32}}

{{TwoLegResult|HC Lokomotiva Zagreb|CRO|57–45|Ardesen GSK|TUR|33–25|24–20}}

{{TwoLegResult|Haukar|ISL|50–51^c|Virto/Quintus|NED|26–29|24–22}}

{{TwoLegResult|H 65 Höör|SWE|52–33|HC Vardar SCJS|MKD|26–13|26–20}}

{{TwoLegResult|ŽRK Mlinotest Ajdovščina|SLO|39–67|Rocasa Gran Canaria ACE|ESP|18–31|21–36}}

{{TwoLegResult|Colégio de Gaia|POR|48–62|Mecalia Atlético Guardés|ESP|26–30|22–32}}

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;Notes:

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:

Teams listed first played the first leg at home. Bolded teams qualified into semifinals.

{{TwoLegStart}}

{{TwoLegResult|Kram Start Elbląg|POL| 43–51 |DHC Sokol Poruba|CZE| 29–24 | 14–27 }}

{{TwoLegResult|H 65 Höör|SWE| 53–45 |Mecalia Atlético Guardés|ESP| 24–21 | 29–24 }}

{{TwoLegResult|Virto/Quintus|NED| 69–41 |LK Zug|SUI| 35–12 | 34–29 }}

{{TwoLegResult|HC Lokomotiva Zagreb|CRO| 52–50 |Rocasa Gran Canaria ACE|ESP| 29–24 | 23–26 }}

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{{TwoLegStart}}

{{TwoLegResult|HC Lokomotiva Zagreb|CRO| 51–39 ^a |Virto/Quintus|NED|24–23 | 27–16 }}

{{TwoLegResult|H 65 Höör|SWE| 50–30 | DHC Sokol Poruba|CZE| 28–16| 22–14 }}

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;Notes:

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{{TwoLegStart}}

{{TwoLegResult|HC Lokomotiva Zagreb|CRO| 47–40 |H 65 Höör|SWE|23–19 | 24–21 }}

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• 2016–17 Women's EHF Champions League
• 2016–17 Women's EHF Cup

{{EHF Challenge Cup seasons}}

{{2016–17 in European handball (EHF)}}

{{2016–17 European club competitions}}

{{DEFAULTSORT:2016-17 EHF Challenge Cup}}

Category:Women's EHF Challenge Cup

EHF Challenge Cup

EHF Challenge Cup