2021 AFC Cup knockout stage#Final

In the knockout stage, the eight teams played a single-elimination tournament. Each tie was played as a single match. Extra time and penalty shoot-out were used to decide the winners if necessary (Regulations Article 9.3 and 10.1).

{{#invoke:Build bracket|main

| rounds=5|boldwinner=y

| RD1 = Zonal semi-finals

| RD2 = Zonal finals

| RD3 = Inter-zone play-off semi-finals

| RD4 = Inter-zone play-off final

| RD5 = Final

| col1-matches = 3,5.5

| col2-matches = 4.5,8.5

| col3-matches = 9.5

| col4-matches = 10.5

| col3-lines = 4.5

| col4-lines = 4.5

| col5-matches = 7.5

| col1-col2-paths = (3,5.5)-4.5

| col2-col3-paths = 4.5-4.5,8.5-9.5

| col3-col4-paths = 4.5-4.5,9.5-10.5

| col4-col5-paths = (4.5,10.5)-7.5

| RD1-team1 = {{fbaicon|BHR}} Al-Muharraq

| RD1-score1 = 3

| RD1-team2 = {{fbaicon|LBN}} Al-Ahed

| RD1-score2 = 0

| RD1-team3 = {{fbaicon|KUW}} Al-Kuwait

| RD1-score3 = 2

| RD1-team4 = {{fbaicon|JOR}} Al-Salt

| RD1-score4 = 0

| RD2-team1 = {{fbaicon|BHR}} Al-Muharraq

| RD2-score1 = 2

| RD2-team2 = {{fbaicon|KUW}} Al-Kuwait

| RD2-score2 = 0

| RD2-team3 = {{fbaicon|UZB}} Nasaf

| RD2-score3 = 3

| RD2-team4 = {{fbaicon|TKM}} Ahal

| RD2-score4 = 2

| RD3-team1 = {{fbaicon|UZB}} Nasaf

| RD3-score1 = 6

| RD3-team2 = {{fbaicon|IND}} ATK Mohun Bagan

| RD3-score2 = 0

| RD4-team1 = {{fbaicon|UZB}} Nasaf {{aet}}

| RD4-score1 = 3

| RD4-team2 = {{fbaicon|HKG}} Lee Man

| RD4-score2 = 2

| RD5-team1 = {{fbaicon|BHR}} Al-Muharraq

| RD5-score1 = 3

| RD5-team2 = {{fbaicon|UZB}} Nasaf

| RD5-score2 = 0

}}

The West Asia Zonal semi-finals were played over one leg, with the home team determined by the draw mechanism based on which group runners-up qualify. A group winner hosted the match against a group runner-up. If two group winners played each other, one of the group winner (whose group runner-up qualify) hosted the match.

{{OneLegStart}}

|+West Asia Zone

{{OneLegResult|Al-Muharraq|BHR|3–0|Al-Ahed|LBN}}

{{OneLegResult|Al-Kuwait|KUW|2–0|Al-Salt|JOR}}

{{end}}

{{OneLegStart}}

|+ASEAN Zone

{{OneLegResult|||{{small|10–11 Aug}}||}}

{{OneLegResult|||{{small|10–11 Aug}}||}}

{{end}}

The West Asia and Central Asia Zonal final were played over one leg, with the home team decided by draw. The winners of the West Asia Zonal final advanced to the final, while the winners of the Central Asia Zonal final advanced to the Inter-zone play-off semi-finals.

{{OneLegStart}}

|+West Asia Zone

{{OneLegResult|Al-Muharraq|BHR|2–0|Al-Kuwait|KUW}}

{{end}}

{{OneLegStart}}

|+Central Asia Zone

{{OneLegResult|Nasaf|UZB|3–2|Ahal|TKM}}

{{end}}

{{OneLegStart}}

|+ASEAN Zone

{{OneLegResult|||{{small|25 Aug}}||}}

{{end}}

After matches in ASEAN Zone was cancelled, there were only three teams which qualified to the Inter-zone play-off semi-finals, i.e., the winners of the South Asia Zone (Group D), the winners of the East Asia Zone (Group J), and the winners of the Central Zonal final. The three Zonal champions were drawn into two pairings where one club got a bye to the Inter-zone play-off final, which happened for Lee Man. The matchups and order of legs decided by draw, without any seeding with the winner of Central Zonal Final hosting the match and the winner of South Asia Zone being the away team.{{cite web |title=Clubs set to discover road to AFC Cup 2021 Final |url=https://www.the-afc.com/competitions/afc-cup/latest/news/clubs-set-to-discover-road-to-afc-cup-2021-final |website=AFC |access-date=3 August 2021}}

{{OneLegStart}}

{{OneLegResult|Nasaf|UZB|6–0|ATK Mohun Bagan|IND}}

{{end}}

In the Inter-zone play-off final, the two teams which advanced from the Inter-zone play-off semi-finals played each other, with the order of legs determined by the Inter-zone play-off semi-final draw. The winners of the Inter-zone play-off final advanced to the final.

{{OneLegStart}}

{{OneLegResult|Nasaf|UZB|3–2 {{aet}}|Lee Man|HKG}}

{{end}}

The final was played over one leg, between the winners of the West Asia Zonal final and the winners of the Inter-zone play-off final. The home team was determined on a rotation basis, with the match hosted by the winners of the West Asia Zonal final, as in the case of odd-numbered years (Regulations 9.1.2).

{{Football box

|date = {{Start date|2021|11|5|df=y}}

|time = {{UTZ|19:00|3}}

|team1 = Al-Muharraq {{fbaicon|BHR}}

|score = 3–0

|team2 = {{fbaicon|UZB}} Nasaf

|goals1 =

• Al-Mardi {{goal|2}}
• Jameel {{goal|74}}
• Carioca {{goal|80}}

|stadium = Al Muharraq Stadium, Arad

|attendance = 9,060

|referee = Ko Hyung-jin (South Korea)

|report = [https://www.the-afc.com/en/matches/afc-cup/2021/2240608 Live Report]
[http://stats.the-afc.com/match_report/20983 Stats Report]

}}