2021 Charlotte 49ers football team

On December 29, 2020 offensive line coach Lee Grimes left to take the same position at Kansas.{{cite web|title=Lee Grimes named KU football’s new offensive line coach|url=http://www2.kusports.com/news/2020/dec/29/lee-grimes-named-ku-footballs-new-offensive-line-c/|date=December 29, 2020|access-date=March 1, 2021}} On February 2, Texas co-offensive coordinator and offensive line coach Herb Hand was named to the same position at Charlotte.{{cite web|title=Healy Announces Home Run Hire in OL Coach Herb Hand|url=https://charlotte49ers.com/news/2021/2/2/football-healy-announces-home-run-hire-in-ol-coach-hand.aspx|website=Charlotte49ers.com|date=February 2, 2021|access-date=March 1, 2021}} By February 18, he accepted a position on Gus Malzahn's new staff at UCF.{{Cite tweet|number=1362533121531408387|user=CoachGusMalzahn|title=Got @CoachHand coming down to Orlando to lead our O-Line!! #ChargeOn|author=Gus Malzahn}} On February 3, wide receivers coach Montario Hardesty joined the South Carolina staff as running backs coach.{{cite web|title=Former Tennessee standout named new Gamecocks running backs coach|url=https://www.thestate.com/sports/college/university-of-south-carolina/usc-football/article248986645.html|date=February 3, 2021|access-date=March 1, 2021}} On February 9, tight ends coach Cody Woodiel returned to the Oregon Ducks as recruiting director.{{cite web|title=Former Oregon Ducks graduate assistant returning as director of recruiting, per report|url=https://www.oregonlive.com/ducks/2021/02/former-oregon-ducks-graduate-assistant-returning-to-mario-cristobals-staff-per-report.html|date=February 9, 2021|access-date=March 4, 2021}} On February 15, South Carolina receivers coach and Charlotte native Joe Cox was named the 49ers' tight ends coach.{{cite web|title=Healy Welcomes Joe Cox Back to Charlotte Area as Tight ends coach|url=https://charlotte49ers.com/news/2021/2/15/football-joe-cox-returns-to-charlotte-area-as-tight-ends-coach.aspx|website=Charlotte49ers.com|date=February 15, 2021|access-date=March 1, 2021}} On February 18 Ridge View High School head coach Perry Parks was brought on to coach wide receivers.{{cite web|title=Healy Hires Parks as Wide receivers coach|url=https://charlotte49ers.com/news/2021/2/18/football-healy-hires-parks-as-wide-receivers-coach-to-complete-staff.aspx|date=February 18, 2021|access-date=March 1, 2021}} On March 3, former NCAA Division II coach of the Year Pete Rossomando came on board to coach offensive line.{{cite web|title=Former National Coach of the Year Rossomando Named Offensive line coach|url=https://charlotte49ers.com/news/2021/3/3/football-former-national-coach-of-the-year-rossomando-named-offensive-line-coach.aspx|date=March 3, 2021|access-date=March 4, 2021}} On June 30, Tyler Hancock joined the staff as special teams coordinator after working as a senior analyst for West Virginia.{{cite web|title=Healy Welcomes Tyler Hancock as Special teams coordinator|url=https://charlotte49ers.com/news/2021/6/30/football-healy-welcomes-tyler-hancock-as-special-teams-coordinator.aspx|date=June 30, 2021|access-date=September 3, 2021}}

The following recruits and transfers have signed letters of intent or verbally committed to the Charlotte 49ers football program for the 2021 recruiting year.

{{College Athlete Recruit Start|40=yes|collapse=yes|year=2021}}

{{College Athlete Recruit Entry

| recruit = Knox Boyd

| position = OL

| hometown = Denton, TX

| highschool = Guyer HS

| feet = 6

| inches = 4

| weight = 290

| 40 = –

| commitdate = 10/19/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = D. J. Brown

| position = LB

| hometown = Memphis, TN

| highschool = Memphis Univ. School

| feet = 6

| inches = 0

| weight = 235

| 40 = –

| commitdate = 12/12/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Cam Burden

| position = LB

| hometown = Sevierville, TN

| highschool = Alcoa HS

| feet = 6

| inches = 3

| weight = 215

| 40 = –

| commitdate = 12/16/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Tyson Clawson

| position = DE

| hometown = Charlotte, NC

| highschool = Independence HS

| feet = 6

| inches = 1

| weight = 230

| 40 = –

| commitdate = 5/16/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Miguel Jackson

| position = DE

| hometown = Gibsonia, PA

| highschool = Pine-Richland HS

| feet = 6

| inches = 2

| weight = 270

| 40 = –

| commitdate = 1/23/21

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Jarius Mack

| position = WR

| hometown = Athens, GA

| highschool = Clarke Central HS

| feet = 5

| inches = 10

| weight = 170

| 40 = –

| commitdate = 6/24/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Douglas Newsome

| position = CB

| hometown = Orange, VA

| highschool = Orange County HS

| feet = 6

| inches = 0

| weight = 175

| 40 = –

| commitdate = 12/16/20

| scout stars = 2

| rivals stars = 2

| 247 stars = 2

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Steven Parker

| position = S

| hometown = Tampa, FL

| highschool = Tampa Bay Tech

| feet = 6

| inches = 2

| weight = 170

| 40 = –

| commitdate = 12/11/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Miles Posey

| position = DE

| hometown = Yorktown, VA

| highschool = Life Christian Academy

| feet = 6

| inches = 3

| weight = 240

| 40 = –

| commitdate = 7/27/20

| scout stars = 2

| rivals stars = 2

| 247 stars = 2

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Isaiah Potts

| position = DT

| hometown = Fayetteville, NC

| highschool = Pine Forest HS

| feet = 6

| inches = 2

| weight = 300

| 40 = –

| commitdate = 8/27/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = B. J. Ragland

| position = OL/DL

| hometown = Chattanooga, TN

| highschool = Red Bank HS

| feet = 6

| inches = 3

| weight = 305

| 40 = –

| commitdate = 11/18/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Bailey Rice

| position = P

| hometown = Melbourne, Australia

| highschool = Hallam Senior College

| feet = 6

| inches = 1

| weight = 205

| 40 = –

| commitdate = 12/16/20

| scout stars =

| rivals stars =

| 247 stars =

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Chavion Smith

| position = RB

| hometown = Statesville, NC

| highschool = Statesville HS

| feet = 5

| inches = 9

| weight = 205

| 40 = –

| commitdate = 7/30/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Elijah Spencer

| position = WR

| hometown = Irmo, SC

| highschool = Dutch Fork HS

| feet = 6

| inches = 2

| weight = 190

| 40 = –

| commitdate = 7/13/20

| scout stars = 3

| rivals stars = 3

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Trevor Timmons

| position = OL

| hometown = Brunswick, GA

| highschool = Blythewood HS

| feet = 6

| inches = 2

| weight = 275

| 40 = –

| commitdate = 10/26/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit Entry

| recruit = Colin Weber

| position = TE

| hometown = Hopkins, MI

| highschool = Hopkins HS

| feet = 6

| inches = 4

| weight = 220

| 40 = –

| commitdate = 12/11/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 2

}}

{{College Athlete Recruit Entry

| recruit = Xavier Williams

| position = QB

| hometown = Moultrie, GA

| highschool = Colquitt County HS

| feet = 6

| inches = 2

| weight = 205

| 40 = –

| commitdate = 12/16/20

| scout stars = 3

| rivals stars = 2

| 247 stars = 3

| espn stars = 3

}}

{{College Athlete Recruit End

| 40 = yes

| year = 2021

| rivals ref title = Charlotte Football Commitments

| scout ref title = 2021 Charlotte Football Commits

| espn ref title = ESPN

| rivals school = charlotte

| scout s = 428

| espn schoolid = 2429

| scout overall = 107

| rivals overall = N/A

| 247 overall = 107

| espn overall = N/A

| access-date = March 1, 2021

| bball =

}}

{{American football roster/Header

| year = 2021

| team = Charlotte 49ers

| teamcolors=y

|offensive_players=

{{American football roster/Player|num=0|class=RFR|first=Trexler|last=Ivey|pos=QB}}

{{American football roster/Player|num=1|class=RSR|first=Victor|last=Tucker|pos=WR|note=C}}

{{American football roster/Player|num=2|class=RSR|first=Dom|last=Shoffner|pos=QB}}

{{American football roster/Player|num=3|class=RSR|first=Chris|last=Reynolds|pos=QB|note=C|link=y|dab=Chris Reynolds (gridiron football)}}

{{American football roster/Player|num=4|class=RSR|first=Cameron|last=Dollar|pos=WR}}

{{American football roster/Player|num=6|class=JR|first=Tre’|last=Goode|pos=WR}}

{{American football roster/Player|num=7|class=RSO|first=James|last=Foster|pos=QB}}

{{American football roster/Player|num=8|class=FR|first=Xavier|last=Williams|pos=QB|rs=y}}

{{American football roster/Player|num=9|class=FR|first=Elijah|last=Spencer|pos=WR}}

{{American football roster/Player|num=10|class=RJR|first=Daniel|last=Ratliff|pos=QB}}

{{American football roster/Player|num=11|class=RFR|first=Taylor|last=Thompson|pos=TE}}

{{American football roster/Player|num=12|class=RFR|first=Donta|last=Armstrong|pos=TE}}

{{American football roster/Player|num=13|class=JR|first=Shadrick|last=Byrd|pos=RB}}

{{American football roster/Player|num=14|class=SO|first=Grant|last=DuBose|pos=WR|link=y}}

{{American football roster/Player|num=15|class=RJR|first=Justin|last=Jeffrey|pos=WR}}

{{American football roster/Player|num=16|class=RSO|first=Kendric|last=Blake Jr.|pos=WR}}

{{American football roster/Player|num=17|class=RJR|first=Ford|last=Werness|pos=WR}}

{{American football roster/Player|num=18|class=FR|first=Colin|last=Weber|pos=TE|rs=y}}

{{American football roster/Player|num=19|class=RSR|first=Keith|last=Pearson Jr.|pos=WR}}

{{American football roster/Player|num=20|class=FR|first=Dominic|last=Green|pos=WR}}

{{American football roster/Player|num=21|class=RFR|first=Elijah|last=Turner|pos=RB}}

{{American football roster/Player|num=22|class=RFR|first=Chris|last=Houston|pos=WR}}

{{American football roster/Player|num=23|class=RFR|first=Andre|last=Francois|pos=WR}}

{{American football roster/Player|num=24|class=FR|first=Chavion|last=Smith|pos=RB}}

{{American football roster/Player|num=25|class=RFR|first=Chavon|last=McEachern|pos=RB}}

{{American football roster/Player|num=26|class=RJR|first=Terrick|last=Smalls Jr.|pos=RB}}

{{American football roster/Player|num=27|class=JR|first=McKinley|last=Nelson|pos=RB}}

{{American football roster/Player|num=28|class=RSO|first=Nolan|last=Groulx|pos=WR}}

{{American football roster/Player|num=29|class=RSO|first=Ricky|last=Kofoed|pos=TE}}

{{American football roster/Player|num=30|class=RFR|first=Keegan|last=Williams|pos=RB}}

{{American football roster/Player|num=32|class=FR|first=Henry|last=Rutledge|pos=RB|rs=y}}

{{American football roster/Player|num=33|class=FR|first=Hahsaun|last=Wilson|pos=RB|rs=y}}

{{American football roster/Player|num=34|class=FR|first=Freddie|last=Felton III|pos=WR}}

{{American football roster/Player|num=37|class=FR|first=Jack|last=Reynolds|pos=WR|rs=y}}

{{American football roster/Player|num=39|class=RSO|first=Teddy|last=Creecy III|pos=WR}}

{{American football roster/Player|num=40|class=FR|first=Bryce|last=Parker|pos=WR}}

{{American football roster/Player|num=51|class=FR|first=B.J.|last=Ragland|pos=OL|rs=y}}

{{American football roster/Player|num=52|class=RFR|first=Jonny|last=King|pos=OL}}

{{American football roster/Player|num=53|class=RFR|first=Panda|last=Askew|pos=OL}}

{{American football roster/Player|num=54|class=RJR|first=Gage|last=Welborn|pos=OL}}

{{American football roster/Player|num=57|class=SR|first=Ashton|last=Gist|pos=OL|rs=y}}

{{American football roster/Player|num=58|class=RSR|first=Jon|last=Jacobs|pos=OL}}

{{American football roster/Player|num=61|class=FR|first=Marshall|last=Futrell|pos=OL|rs=y}}

{{American football roster/Player|num=63|class=FR|first=Trevor|last=Timmons|pos=OL|rs=y}}

{{American football roster/Player|num=64|class=FR|first=Victor|last=Lofton|pos=OL}}

{{American football roster/Player|num=66|class=RSO|first=Navardo|last=Miller|pos=OL}}

{{American football roster/Player|num=68|class=FR|first=D.J.|last=Therrell|pos=OL}}

{{American football roster/Player|num=69|class=RJR|first=Dejan|last=Rasuo|pos=OL}}

{{American football roster/Player|num=70|class=RSR|first=D'Mitri|last=Emmanuel|pos=OL}}

{{American football roster/Player|num=71|class=RFR|first=Arabee|last=Muslim|pos=OL}}

{{American football roster/Player|num=72|class=RFR|first=Cameron|last=Clark|pos=OL}}

{{American football roster/Player|num=74|class=FR|first=Knox|last=Boyd|pos=OL|rs=y}}

{{American football roster/Player|num=75|class=RSR|first=T.J.|last=Moore|pos=OL}}

{{American football roster/Player|num=76|class=FR|first=Jordan|last=Brown|pos=OL|rs=y}}

{{American football roster/Player|num=77|class=RSO|first=Jaxon|last=Hughes|pos=OL}}

{{American football roster/Player|num=78|class=RSR|first=Hunter|last=Kelly|pos=OL}}

{{American football roster/Player|num=79|class=RSR|first=Chibueze|last=Nwanna|pos=OL}}

{{American football roster/Player|num=80|class=FR|first=Jairus|last=Mack|pos=WR}}

{{American football roster/Player|num=81|class=RFR|first=Jake|last=Clemons|pos=TE}}

{{American football roster/Player|num=82|class=RSO|first=Jaylan|last=Williams|pos=TE}}

{{American football roster/Player|num=83|class=RJR|first=Chris|last=Wiggins|pos=WR}}

{{American football roster/Player|num=84|class=FR|first=Khilen|last=Holliman|pos=WR}}

{{American football roster/Player|num=85|class=RSR|first=Ryan|last=Carriere|pos=TE}}

{{American football roster/Player|num=86|class=RFR|first=Bryce|last=Kennon|pos=TE}}

{{American football roster/Player|num=87|class=RJR|first=Chylon|last=Thomas|pos=WR}}

{{American football roster/Player|num=88|class=FR|first=Riley|last=Engelhard|pos=TE}}

{{American football roster/Player|num=89|class=RSO|first=Quinton|last=Patten|pos=WR}}

{{American football roster/Player|num=93|class=RSR|first=Emmanuel|last=White|pos=TE}}

{{American football roster/Player|num=|class=RSO|first=Preston|last=Brown|pos=QB}}

{{American football roster/Player|num=|class=FR|first=Ryan|last=Tyson|pos=QB}}

|defensive_players=

{{American football roster/Player|num=0|class=SR|first=Markees|last=Watts|pos=DE|link=y}}

{{American football roster/Player|num=1|class=RSR|first=Jon|last=Alexander|pos=DB}}

{{American football roster/Player|num=2|class=RSR|first=Justin|last=Whisenhunt|pos=LB}}

{{American football roster/Player|num=3|class=RSR|first=Trey|last=Creamer|pos=DB}}

{{American football roster/Player|num=4|class=SR|first=Geo|last=Howard|pos=CB|rs=y}}

{{American football roster/Player|num=5|class=RSR|first=Tyler|last=Murray|pos=LB|note=C}}

{{American football roster/Player|num=6|class=JR|first=Soloman|last=Rogers|pos=DB}}

{{American football roster/Player|num=7|class=RSR|first=Kofi|last=Wardlow|pos=DE}}

{{American football roster/Player|num=8|class=FR|first=Cam|last=Burden|pos=LB|rs=y}}

{{American football roster/Player|num=9|class=RSR|first=Joshua|last=Bailey|pos=DE}}

{{American football roster/Player|num=10|class=RSR|first=Davondre|last=Robinson|pos=DB|inj=y}}

{{American football roster/Player|num=12|class=RFR|first=Shedrick|last=Ursery|pos=DB}}

{{American football roster/Player|num=13|class=RFR|first=Briston|last=Bennett|pos=DB}}

{{American football roster/Player|num=14|class=FR|first=Steven|last=Parker|pos=S|rs=y}}

{{American football roster/Player|num=15|class=So|first=Jarvis|last=Martin|pos=DB|rs=y}}

{{American football roster/Player|num=16|class=RFR|first=Valerian|last=Agbaw|pos=DB}}

{{American football roster/Player|num=17|class=RSR|first=Luke|last=Martin|pos=LB|note=C}}

{{American football roster/Player|num=18|class=RJR|first=Lance|last=McMillan|pos=DB}}

{{American football roster/Player|num=19|class=RFR|first=Comanche|last=Frncisco|pos=LB}}

{{American football roster/Player|num=20|class=FR|first=Doug|last=Newsome|pos=CB}}

{{American football roster/Player|num=21|class=FR|first=Shyhiem|last=Scotland|pos=LB|rs=y}}

{{American football roster/Player|num=22|class=RSO|first=Marcus|last=Robitaille|pos=DB}}

{{American football roster/Player|num=23|class=RJR|first=Matt|last=Martinez|pos=DB}}

{{American football roster/Player|num=24|class=RSO|first=Lacy|last=Williams|pos=DB}}

{{American football roster/Player|num=25|class=RSO|first=Prince|last=Bemah|pos=LB}}

{{American football roster/Player|num=26|class=SO|first=Shamar|last=Baker|pos=DB}}

{{American football roster/Player|num=27|class=RJR|first=Bryson|last=Whitehead|pos=DB}}

{{American football roster/Player|num=28|class=JR|first=J.J.|last=Jones|pos=DB}}

{{American football roster/Player|num=29|class=RJR|first=Jonnie|last=Pitman|pos=DB}}

{{American football roster/Player|num=30|class=RSO|first=Derek|last=Boykins|pos=LB}}

{{American football roster/Player|num=31|class=RSO|first=Trey|last=Bly|pos=DB}}

{{American football roster/Player|num=32|class=FR|first=John|last=Anderson|pos=DB|rs=y}}

{{American football roster/Player|num=33|class=JR|first=Jaylon|last=Sharpe|pos=LB}}

{{American football roster/Player|num=34|class=FR|first=Boyd|last=Farmer|pos=DB}}

{{American football roster/Player|num=35|class=RSR|first=Antone|last=Williams|pos=DB}}

{{American football roster/Player|num=36|class=FR|first=D.J.|last=Brown|pos=LB|rs=y}}

{{American football roster/Player|num=38|class=RFR|first=Anthony|last=Jackson|pos=DB}}

{{American football roster/Player|num=40|class=RJR|first=Rayshaad|last=Roddy|pos=DL}}

{{American football roster/Player|num=43|class=FR|first=Isaiah|last=Turnage|pos=LB|rs=y}}

{{American football roster/Player|num=44|class=RSR|first=Mikel|last=Horton|pos=DL}}

{{American football roster/Player|num=48|class=RFR|first=Barutti|last=Mazangu|pos=DL}}

{{American football roster/Player|num=50|class=RFR|first=Darion|last=Smith|pos=DL}}

{{American football roster/Player|num=51|class=RSR|first=Peter|last=Agabe|pos=LB}}

{{American football roster/Player|num=53|class=RSO|first=Michael|last=Kelly|pos=DL}}

{{American football roster/Player|num=55|class=FR|first=Isaiah|last=Potts|pos=DT|rs=y}}

{{American football roster/Player|num=56|class=RFR|first=Jordan|last=Moore|pos=DL}}

{{American football roster/Player|num=57|class=RSR|first=Siah|last=Sa'o|pos=DL}}

{{American football roster/Player|num=59|class=RJR|first=B.J.|last=Turner|pos=LB}}

{{American football roster/Player|num=60|class=RJR|first=Bryan|last=Wallace|pos=DL}}

{{American football roster/Player|num=90|class=RFR|first=Dez|last=Morgan|pos=DL}}

{{American football roster/Player|num=91|class=RSR|first=Corey|last=Mobley|pos=DE}}

{{American football roster/Player|num=92|class=FR|first=Miles|last=Posey|pos=DE|rs=y}}

{{American football roster/Player|num=94|class=RJR|first=Isaiah|last=Belk|pos=DE}}

{{American football roster/Player|num=95|class=FR|first=Miguel|last=Jackson|pos=DE|rs=y}}

{{American football roster/Player|num=96|class=RSR|first=Isaac|last=Hampton|pos=DL}}

{{American football roster/Player|num=97|class=RFR|first=Jalar|last=Holley|pos=DL}}

{{American football roster/Player|num=98|class=FR|first=Tyson|last=Clawson|pos=DE}}

{{American football roster/Player|num=99|class=RJR|first=Taylor|last=Chandler|pos=DE}}

|special_teams_players=

{{American football roster/Player|num=11|class=SR|first=Jonathan|last=Cruz|pos=K}}

{{American football roster/Player|num=37|class=FR|first=Bailey|last=Rice|pos=P}}

{{American football roster/Player|num=39|class=RFR|first=Colby|last=Garfield|pos=LS}}

{{American football roster/Player|num=41|class=JR|first=Doug|last=McLaughlin|pos=LS}}

{{American football roster/Player|num=42|class=FR|first=Alex|last=Schattin|pos=P}}

{{American football roster/Player|num=43|class=RSO|first=Max|last=Bilstein|pos=K}}

{{American football roster/Player|num=44|class=RJR|first=Zach|last=Nicholson|pos=P/K}}

{{American football roster/Player|num=45|class=RSR|first=Cameron|last=Lyons|pos=LS}}

{{American football roster/Player|num=46|class=FR|first=Aidan|last=Laros|pos=K|rs=y}}

{{American football roster/Player|num=47|class=RSR|first=Ethan|last=Torres|pos=P/K}}

}}

{{American football roster/Footer|roster_url=https://charlotte49ers.com/roster.aspx?path=football|access-date=September 3, 2021

|head_coach=

• Will Healy ({{college|Richmond}})

|asst_coach=

• Marcus West ({{college|Memphis}})
  Assistant head coach/co-Defensive coordinator/defensive line
  
• Mark Carney ({{college|Fordham}})
  Offensive coordinator/quarterbacks
  
• Brandon Cooper ({{college|UT Martin}})
  Co-defensive coordinator/safeties
  
• Adam Braithwaite ({{college|William & Mary}})
  Linebackers
  
• Joe Cox ({{college|Georgia}})
  Tight ends
  
• Sean Dawkins ({{college|Troy}})
  Run Game Coordinator/running backs
  
• Tyler Hancock ({{college|Kentucky Wesleyan}})
  Special teams coordinator
  
• Eddie Hicks ({{college|Southern Miss}})
  Cornerbacks
  
• Pete Rossomando ({{college|Boston University}})
  Offensive line
  
• Perry Parks ({{college|Coastal Carolina}})
  Wide receivers
  

|otherlegend=

}}

{{CFB Team Depth Chart

| OScheme = Single Set Back

| DScheme = 4-3

| SpecialTeams = Yes

| KeyReserves = No

| 3Deep = Yes

| QB_Starter = CHRIS REYNOLDS

| QB_Backup = James Foster

| QB_Third =

| RB1_Starter = CALVIN CAMP

| RB1_Backup = Shadrick Byrd

| RB1_Third =

| RB2_Starter =

| RB2_Backup =

| RB2_Third =

| FB_Starter =

| FB_Backup =

| FB_Third =

| SB1_Starter =

| SB1_Backup =

| SB1_Third =

| SB1_SchoolName =

| SB2_Starter =

| SB2_Backup =

| SB2_Third =

| WR1_Starter = VICTOR TUCKER

| WR1_Backup = Keith Pearson Jr.

| WR1_Third =

| WR1_SchoolName =

| WR2_Starter = CAMERON DOLLAR

| WR2_Backup = Tre' Goode

| WR2_Third =

| WR2_SchoolName =

| WR3_Starter = GRANT DUBOSE

| WR3_Backup = Ejijah Spencer

| WR3_Third =

| WR3_SchoolName =

| WR4_Starter =

| WR4_Backup =

| WR4_Third =

| WR4_SchoolName =

| TE1_Starter = RYAN CARRIERE

| TE1_Backup = Taylor Thompson

| TE1_Third =

| TE1_SchoolName =

| TE2_Starter =

| TE2_Backup =

| TE2_Third =

| LT_Starter = JAXON HUGHES

| LT_Backup = Chibueze Nwanna

| LT_Third =

| LG_Starter = D’MITRI EMMANUEL

| LG_Backup = Panda Askew

| LG_Third =

| C_Starter = HUNTER KELLY

| C_Backup = Jonny King

| C_Third =

| RG_Starter = ASHTON GIST

| RG_Backup = Dejan Rasuo

| RG_Third =

| RT_Starter = T.J. MOORE

| RT_Backup = Arabee Muslim

| RT_Third =

| WLB_Starter = TYLER MURRAY

| WLB_Backup =

| WLB_Third =

| WLB_SchoolName =

| ROLB_Starter =

| ROLB_Backup = Solomon Rogers

| ROLB_Third =

| ROLB_SchoolName =

| RILB_Starter =

| RILB_Backup =

| RILB_Third =

| RILB_SchoolName =

| MLB_Starter = LUKE MARTIN

| MLB_Backup = B.J. Turner

| MLB_Third =

| MLB_SchoolName =

| LILB_Starter =

| LILB_Backup =

| LILB_Third =

| LILB_SchoolName =

| SLB_Starter = JUSTIN WHISENHUNT

| SLB_Backup = Prince Bemah

| SLB_Third =

| SLB_SchoolName =

| FS_Starter = JON ALEXANDER

| FS_Backup = Steven Parker

| FS_Third =

| SS_Starter = SOLOMON ROGERS

| SS_Backup = Matt Martinez

| SS_Third = Marcus Robitaille

| SS_SchoolName =

| S_Starter =

| S_Backup =

| S_Third =

| S_SchoolName =

| DB1_Starter = TREY CREAMER

| DB1_Backup = Shedrick Ursery

| DB1_Third =

| DB2_Starter = GEO HOWARD

| DB2_Backup = Lance McMillan

| DB2_Third = Valerian Agbaw

| RDE_Starter = MARKEES WATTS

| RDE_Backup = Tyson Clawson

| RDE_Third = Taylor Chandler

| RDT_Starter = BRYAN WALLACE

| RDT_Backup = Siah Sa'o

| RDT_Third = Joshua Bailey

| NT_Starter =

| NT_Backup =

| NT_Third =

| LDT_Starter = ISAAC HAMPTON

| LDT_Backup = Dez Morgan

| LDT_Third =

| LDE_Starter = KOFI WARDLOW

| LDE_Backup = Michael Kelly

| LDE_Third =

| DE_SchoolName =

| PK_Starter = Jonathan Cruz

| PK_Backup = Max Blitstein

| P_Starter = Bailey Rice

| P_Backup = Ethan Torres

| Kick_Returner = Calvin Camp

| Punt_Returner = Geo Howard

| Long_Snapper = Cameron Lyons

| Holder = Chris Reynolds

| Key_Reserve_1 =

| Key_Reserve_2 =

| Key_Reserve_3 =

| Key_Reserve_4 =

| Key_Reserve_5 =

| Key_Reserve_6 =

| Key_Reserve_7 =

| Key_Reserve_8 =

| OffenseRef = Pro-style

| DefenseRef = 4–3

| ColWidth = 100

| FontSize = 90

| Debug = No

}}

All Conference Honorable Mentions:{{cite web|title=Nine Earn Honorable Mention All-C-USA Recognition|url=https://charlotte49ers.com/news/2021/12/7/football-nine-earn-honorable-mention-all-c-usa-recognition.aspx|date=December 7, 2021|access-date=December 7, 2021}}

Offense:

QB – Chris Reynolds, R-Sr. •

TE – Ryan Carriere, Gr. •

WR – Grant DuBose, So. •

OL – Ashton Gist, Sr. •

OL – Hunter Kelly, Gr.

Defense:

DE – Markees Watts, R-Sr. •

LB – Tyler Murray, R-Sr.

Special Teams:

KR – Shadrick Byrd, R-Fr. •

LS – Cameron Lyons, Gr.

{{CFB schedule

| time = y

| tv = y

| attend = y

| opprank = y

| rankyear = 2021

| rankdivision = NCAA Division I FBS

| poll = AP Poll and CFP Rankings

| timezone = Eastern

|{{CFB schedule entry

| date = {{tooltip|September 3|Friday}}

| time = 7:00 p.m.

| w/l = w

| homecoming =

| nonconf = y

| rank =

| opponent = Duke

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = CBSSN

| score = 31–28

| attend = 14,125

}}

|{{CFB schedule entry

| date = September 11

| time = 6:00 p.m.

| w/l = w

| homecoming =

| nonconf = y

| rank =

| opponent = Gardner–Webb

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = ESPN3

| score = 38–10

| attend = 12,274

}}

|{{CFB schedule entry

| date = September 18

| time = 7:00 p.m.

| w/l = l

| away = y

| homecoming =

| nonconf = y

| rank =

| opponent = Georgia State

| site_stadium = Center Parc Stadium

| site_cityst = Atlanta, GA

| tv = ESPN+

| score = 9–20

| attend = 12,978

}}

|{{CFB schedule entry

| date = {{tooltip|September 24|Friday}}

| time = 6:30 p.m.

| w/l = w

| homecoming =

| nonconf =

| rank =

| opponent = Middle Tennessee

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = CBSSN

| score = 42–39

| attend = 11,076

}}

|{{CFB schedule entry

| date = October 2

| time = 12:00 p.m.

| w/l = l

| homecoming =

| away = y

| nonconf = y

| rank =

| opponent = Illinois

| site_stadium = Memorial Stadium

| site_cityst = Champaign, IL

| tv = BTN

| score = 14–24

| attend = 30,559

}}

|{{CFB schedule entry

| date = {{tooltip|October 8|Friday}}

| time = 7:00 p.m.

| w/l = w

| away = y

| homecoming =

| nonconf =

| rank =

| opponent = FIU

| site_stadium = Riccardo Silva Stadium

| site_cityst = Miami, FL

| tv = CBSSN

| score = 45–33

| attend = 0

}}

|{{CFB schedule entry

| date = {{tooltip|October 21|Thursday}}

| time = 7:30 p.m.

| w/l = l

| homecoming =

| nonconf =

| rank =

| opponent = Florida Atlantic

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = CBSSN

| score = 9–38

| attend = 13,017

}}

|{{CFB schedule entry

| date = October 30

| time = 4:00 p.m.

| w/l = l

| away = y

| homecoming =

| nonconf =

| rank =

| opponent = Western Kentucky

| site_stadium = Houchens Industries–L. T. Smith Stadium

| site_cityst = Bowling Green, KY

| tv = ESPN+

| score = 13–45

| attend = 16,763

}}

|{{CFB schedule entry

| date = November 6

| time = 3:30 p.m.

| w/l = w

| homecoming = y

| nonconf =

| rank =

| opponent = Rice

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = ESPN+

| score = 31–24

| overtime = OT

| attend = 16,050

}}

|{{CFB schedule entry

| date = November 13

| time = 3:30 p.m.

| w/l = l

| away = y

| homecoming =

| nonconf =

| rank =

| opponent = Louisiana Tech

| site_stadium = Joe Aillet Stadium

| site_cityst = Ruston, LA

| tv = Stadium

| score = 32–42

| attend = 14,068

}}

|{{CFB schedule entry

| date = November 20

| time = 3:30 p.m.

| w/l = l

| homecoming =

| nonconf =

| rank =

| opponent = Marshall

| site_stadium = Jerry Richardson Stadium

| site_cityst = Charlotte, NC

| tv = Stadium

| score = 28–49

| attend = 13,211

}}

|{{CFB schedule entry

| date = November 27

| time = 2:00 p.m.

| w/l = l

| away = y

| homecoming =

| nonconf =

| rank =

| opponent = Old Dominion

| site_stadium = S.B. Ballard Stadium

| site_cityst = Norfolk, VA

| gamename = Oyster Bowl

| tv = ESPN+

| score = 34–56

| attend = 15,874

}}

}}

{{notelist|group=schedule}}

{{Clear}}

{{cite web |title=2021 Charlotte Football Schedule |url=https://fbschedules.com/charlotte-football-schedule/ |website=FBSchedules.com |access-date=January 31, 2021}}

Charlotte 49ers home games and conference road games will be broadcast through Conference USA's television partners ESPN, CBS Sports, and Stadium.{{cite web|title=C-USA Announces 2021 Football Broadcast Schedule|url=https://charlotte49ers.com/news/2021/6/1/c-usa-announces-2021-football-game-times-and-broadcast-info.aspx|website=Charlotte49ers.com|date=June 1, 2021|access-date= September 5, 2021}}

Radio coverage for all games is broadcast by IMG College through the Charlotte 49ers Radio Network flagship station WZGV ESPN Radio 730 AM The Game, and the TuneIn Charlotte 49ers IMG Sports Network app. The radio announcers are "Voice of the 49ers" Matt Swierad with play-by-play alongside NFL veteran Al Wallace providing color commentary and Bobby Rosinski and Walker Mehl with sideline reports.{{cite web|title=Niners Live Begins Monday|url=https://charlotte49ers.com/news/2019/8/20/niners-live-begins-monday.aspx?path=footballl|website=Charlotte49ers.com|date=August 20, 2019|access-date= September 5, 2021}}

Conference USA released their preseason media poll on July 19, 2021, with the 49ers predicted to finish in fourth place in the East Division.{{cite web|url=https://conferenceusa.com/news/2021/7/19/football-c-usa-announces-medias-predicted-order-of-finish-for-2021.aspx|title=C-USA Announces Media's Predicted Order of Finish For 2021|date=July 19, 2021|access-date=September 5, 2021|website=conferenceusa.com|publisher=Conference USA}}

{{see also|2021 Conference USA football season}}

{{See also|2021 Duke Blue Devils football team}}

{{AFB game box start

|Title=Duke vs Charlotte

|Visitor=Blue Devils

|Host=49ers

|V1=0|V2=14|V3=0|V4=14

|H1=7|H2=3|H3=7|H4=14

|Date=September 3, 2021

|Location=Jerry Richardson Stadium
Charlotte, NC

|TimeZone=EDT

|StartTime=7:03 p.m.

|ElapsedTime= 4:05

|Attendance= 14,125

|Weather=Temperature: {{Convert|80|°F|°C}} • Weather: Sunny • Wind: NE 0 MPH

|Referee=Riley Johnson

|TVAnnouncers=Chris Lewis, Corey Chavous, and Justin Walters

|TVStation=CBSSN

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte Hosts Duke Friday Night|url=https://charlotte49ers.com/news/2021/8/31/football-game-notes-charlotte-hosts-duke-friday-night.aspx|website=Charlotte49ers.com|date=August 31, 2021|access-date=September 5, 2021}}{{cite web|title=Late-Game Heroics Secure Charlotte's First Power Five Win, 31–28, Over Duke|url=https://charlotte49ers.com/news/2021/9/3/charlotte-duke-recap.aspx|date=September 3, 2021|access-date=September 5, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Duke vs Charlotte (Sept 3, 2021 at Charlotte, N.C.)|url=https://charlotte49ers.com/documents/2021/9/3/Charlotte_vs_Duke_FINAL_Game_Book.pdf|date=September 3, 2021|access-date=September 5, 2021}}{{cite web|title=Duke vs Charlotte – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282052|work=ESPN|date=September 3, 2021|access-date=September 5, 2021}}{{cite news|title=Grant DuBose worked in an Alabama Walmart last season. Friday, he led Charlotte past Duke|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article253996248.html|newspaper=The Charlotte Observer|date=September 4, 2021|access-date=September 5, 2021}}{{cite web|title=TPA:Charlotte 31 Duke 28|url=https://charlotte49ers.com/news/2021/9/4/football-the-point-after-charlotte-31-duke-28.aspx|website=Charlotte49ers.com|date=September 4, 2021|access-date=September 5, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=8:51|Team=CHAR|Event=Grant DUBOSE 56 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7–0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=10:22|Team=CHAR|Event=Jonathan CRUZ 32 Yd Field Goal|Score=CHAR 10–0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=8:22|Team=DUKE|Event=Jordan WATERS 43 Yd pass from Gunnar HOLMBERG (Charlie HAM Kick)|Score=CHAR 10–7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=2:57|Team=DUKE|Event=Mataeo DURANT 5 Yd Run (Charlie HAM Kick)|Score=DUKE 14–10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=9:54|Team=CHAR|Event=Chris REYNOLDS 1 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 17–14}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=13:07|Team=DUKE|Event=Mataeo DURANT 59 Yd Run (Charlie HAM Kick)|Score=DUKE 21–17}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=2:59|Team=CHAR|Event=Grant DUBOSE 9 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 24–21}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=1:44|Team=DUKE|Event=Mataeo DURANT 53 Yd Run (Charlie HAM Kick)|Score=DUKE 28–24}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=0:33|Team=CHAR|Event=Shadrick BYRD 11 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 31–28|LastEntry=yes}}

{{AFB game box end}}

Following the previous year's drubbing in Durham, the 49ers were looking to regain their pride against the Blue Devils in the first full stadium home game since the 2019 season. The 49ers would score first in the first quarter on a Grant DuBose reception from Chris Reynolds and pad their lead early in the second quarter on a Jonathan Cruz 32 yard field goal. But the Blue Devils would find the endzone midway through the quarter and then take their first lead near the end of the half behind Mataeo Durant's first of three rushing touchdowns to take a 14 to 10 lead into the locker rooms.

Charlotte would regain the lead in the third quarter only to lose it again early in the fourth quarter. With three minutes left Charlotte would again take the lead only to see the Blue Devils again on top of the scoreboard with less than two minutes in regulation. Reynolds would then orchestrate a seven-play drive downfield that resulted in an eleven-yard touchdown pass to Shadrick Byrd with only thirty-three seconds left on the clock. With time expired Duke attempted a hook-and-ladder play, but the 49ers would stop it cold and gain their first victory over a Power 5 and ACC opponent in program history.

Top performances for the game included Charlotte's Chris Reynolds, who threw for 324 yards and three touchdowns. Duke's Mataeo Durant had 29 carries for 255 yards and 3 touchdowns. The 49er's Victor Tucker had 8 receptions for 133 yards. Charlotte's Grant DuBose also had 118 yards receiving with two touchdowns in his 49ers debut.

Game notes:

• Charlotte's first victory over a Power 5 conference team and a team from the ACC.
• First time the 49ers have hosted a Power 5 conference team.
• The win was also Coach Healy's first victory over a Power 5 opponent.
• Chris Reynold's is now 39 yards away from breaking Matt Johnson's all-time passing record (5405 yards).
• Reynolds is also chasing Johnson's all-time passing touchdowns record, just 3 shy of Johnson's 42 career TDs.
• Reynolds was named Conference USA Offensive Player of the Week.
• Markees Watts' single sack placed him a half-sack away from Larry Ogunjobi's (13.0) number 2 spot on the 49ers all-time sack record. Alex Highsmith has the current career sack record with 20.0.
• Charlotte received votes for the first time in the National Coaches Poll after the win.{{cite web|title=GAME NOTES: Charlotte vs. Gardner-Webb|url=https://charlotte49ers.com/news/2021/9/8/football-game-notes-charlotte-vs-gardner-webb.aspx|website=Charlotte49ers.com|date=September 8, 2021|access-date=September 8, 2021}}
• 2nd game in the series since 2020 (Tied 1–1).

{{Clear}}

{{see also|2021 Gardner–Webb Runnin' Bulldogs football team}}

{{AFB game box start

| Title =Gardner–Webb vs Charlotte

| Visitor =Runnin' Bulldogs

| Host =49ers

| V1 =3 | V2 =7 | V3 =0 | V4 =0

| H1 =14 | H2 =14 | H3 =7 | H4 =3

| Date = September 11

| Location = Jerry Richardson Stadium
Charlotte, NC

| TimeZone=EDT

| StartTime = 6:04 pm

| ElapsedTime = 3:15

| Attendance = 12,274

| Weather = {{Convert|81|°F|°C}} • Weather: Sunny • Wind: SW 5 MPH

| Referee = Joe Lehring

|TVAnnouncers=Jack Fitzpatrick, Reggie Walker Jr.

|TVStation= ESPN3

}}

• Sources:{{cite web|title=Reynolds Breaks All-Time Record; Charlotte Rushes Past Gardner-Webb, 38–10|url=https://charlotte49ers.com/news/2021/9/11/football-charlotte-rushes-past-gardner-webb-38-10.aspx|date=September 11, 2021|access-date=September 12, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Gardner-Webb vs Charlotte (Sept 11, 2021 at Charlotte, N.C.)|url=https://charlotte49ers.com/football/2021/boxscore/vs-gardner-webb/15608/pdf|date=September 11, 2021|access-date=September 12, 2021}}{{cite web|title=Gardner-Webb vs Charlotte – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282181|work=ESPN|date=September 11, 2021|access-date=September 12, 2021}}{{cite news|title=Charlotte runs over Gardner-Webb; 49ers are off to their best start in six years|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article254073168.html|newspaper=The Charlotte Observer|date=September 11, 2021|access-date=September 12, 2021}}{{cite web|title=TPA:Charlotte 38 Gardner-Webb 10|url=https://charlotte49ers.com/news/2021/9/12/football-the-point-after-charlotte-38-gardner-webb-10.aspx|website=Charlotte49ers.com|date=September 12, 2021|access-date=September 13, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=12:08|Team=CHAR|Event=Chris REYNOLDS 37 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 7–0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=8:31|Team=GWU|Event=Austin MCKAY 45 Yd Field Goal|Score=CHAR 7–3}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=1:32|Team=CHAR|Event=Shadrick BYRD 5 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 14–3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=9:42|Team=CHAR|Event=Calvin CAMP 1 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 21–3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=7:47|Team=GWU|Event=Narii GAITHER 14 Yd Run (Austin MCKAY Kick)|Score=CHAR 21–10}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=3:43|Team=CHAR|Event=Jairus MACK 11 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 28–10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=10:52|Team=CHAR|Event=Chavon MCEACHERN 13 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 35–10}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=12:46|Team=CHAR|Event=Jonathan CRUZ 29 Yd Field Goal|Score=CHAR 38–10|LastEntry=yes}}

{{AFB game box end}}

The 49ers were looking to build off of the previous week's success by dominating local rival Gardner-Webb Runnin' Bulldogs. Charlotte would find the endzone first and never really looked back as they were able to hold Gardner-Webb to 10 total points of offense. Charlotte's bend-but-don't-break defense allowed GWU to move the ball down the field but was able to frustrate most of the Runnin' Bulldogs' scoring attempts as the 49ers walked away with a 38 to 10 home victory.

Top performances of the game included the 49ers' Chris Reynolds who threw for 103 yards and a touchdown with 2 interceptions. Gardner-Webb's Narii Gaither had 16 carries for 82 yards and a touchdown. The Runnin' Bulldogs' Justin Franklin had 4 receptions for 53 yards.

Game notes:

• Chris Reynolds would connect to his favorite receiver of 4 years Victor Tucker on a 28 yard pass in the 3rd quarter to move into 1st place all-time on the 49ers passing yardage board. He'd finish the game with 5,469 career passing yards, moving past previous record holder Matt Johnson's 5,405 yards.
• Reynolds is now 2 passing touchdowns away from tying Johnson's career touchdown passes record (42).
• Markees Watts' sack in this game moved him past Larry Ogunjobi into second place on the 49ers career sacks list with 13.5 sacks.
• 4th game in the series since 2013, (Char. 3–1)

{{Clear}}

{{see also|2021 Georgia State Panthers football team}}

{{AFB game box start

| Title =Charlotte vs Georgia State

| Visitor =49ers

| Host =Panthers

| V1 =0 | V2 =7 | V3 =2 | V4 =0

| H1 =0 | H2 =7 | H3 =6 | H4 =7

| Date = September 18

| Location = Center Parc Stadium
Atlanta, GA

| TimeZone=EDT

| StartTime = 7:05 pm

| ElapsedTime = 3:12

| Attendance = 12,978

| Weather = {{Convert|78|°F|°C}} • Weather: Cloudy• Wind: SW 4 MPH

| Referee = Kevin Vicknair

|TVAnnouncers=Matt Stewart, Sam Crenshaw

|TVStation= ESPN+

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte at Georgia State|url=https://charlotte49ers.com/news/2021/9/15/football-game-notes-charlotte-at-georgia-state.aspx|website=Charlotte49ers.com|date=September 15, 2021|access-date=September 15, 2021}}{{cite web|title=Charlotte Suffers First Loss on Road at Georgia State, 20–9|url=https://charlotte49ers.com/news/2021/9/18/football-charlotte-suffers-first-loss-on-road-at-georgia-state-20-9.aspx|date=September 18, 2021|access-date=September 20, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte vs Georgia St. (Sept 18, 2021 at Atlanta, G.A.)|url=https://charlotte49ers.com/documents/2021/9/18/GSU03_Charlotte.PDF|date=September 18, 2021|access-date=September 20, 2021}}{{cite web|title=Charlotte vs Georgia St. – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282196|work=ESPN|date=September 18, 2021|access-date=September 20, 2021}}{{cite news|title=Charlotte’s lack of offensive execution led to a 49ers loss. Here’s what else we learned|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article254365978.html|newspaper=The Charlotte Observer|date=September 19, 2021|access-date=September 20, 2021}}{{cite web|title=TPA:Charlotte at Georgia State|url=https://charlotte49ers.com/news/2021/9/19/football-the-point-after-charlotte-at-georgia-state.aspx|website=Charlotte49ers.com|date=September 19, 2021|access-date=September 20, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=2|Time=7:41|Team=CHAR|Event=Elijah SPENCER 36 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7–0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=4:03|Team=GAST|Event=Jamari THRASH 35 Yd pass from Darren GRAINGER (Noel RUIZ Kick)|Score=TIED 7–7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=9:45|Team=CHAR|Event=Team Safety|Score=CHAR 9–7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=5:06|Team=GAST|Event=Ja'Cyais CREDEL 28 Yd pass from Darren GRAINGER (Noel RUIZ PAT blocked)|Score=GAST 13–9}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=1:38|Team=GAST|Event=Jamyest WILLIAMS 13 Yd Run (Noel RUIZ Kick)|Score=GAST 20–9|LastEntry=yes}}

{{AFB game box end}}

Rain and slick conditions would help turn this matchup into a ground and pound event dominated be defense. Charlotte would score first in the second quarter but Georgia State would tie it up moving into halftime.

The second half resulted in Charlotte retaking the lead on an intention grounding safety, but the Panthers would retake the lead before the end of the quarter. The 4th quarter was more of the same running game for both teams but Georgia State was able to find their running game rhythm and would put the game out of reach on a final touchdown with less than two minutes to go in the contest.

Georgia State dominated the top performances with Darren Grainger passing for 139 yards, 2 touchdowns and an interception. Running back Dustin Coates had 4 carries for 83 yards. Jamari Thrash had 2 receptions for 62 yards and a touchdown.

Game notes:

• The 2nd quarter touchdown pass from Chris Reynolds to Elijah Spencer was Reynolds' 41st career pass. He was one touchdown pass away from tying the 49ers career passing TD leader Matt Johnson (42).
• Jonathan Cruz broke the record for consecutive PATs, passing Blake Brewer's record of 46.
• The 49ers' first visit to Center Parc Stadium. The previous meeting in Atlanta took place in the Georgia Dome.
• 3rd game in the series since 2015, (GAST 2–1)

{{Clear}}

{{see also|2021 Middle Tennessee Blue Raiders football team}}

{{AFB game box start

| Title =Middle Tennessee vs Charlotte

| Visitor =Blue Raiders

| Host =49ers

| V1 =7 | V2 =10 | V3 =7 | V4 =15

| H1 =14 | H2 =0 | H3 =14 | H4 =14

| Date = September 24

| Location = Jerry Richardson Stadium
Charlotte, NC

| TimeZone=EDT

| StartTime = 6:32 pm

| ElapsedTime = 3:44

| Attendance = 11,076

| Weather = {{Convert|73|°F|°C}} • Weather: Sunny • Wind: N 6 MPH

| Referee = Tony Johnson

|TVAnnouncers= Chris Lewis, Corey Chavous

|TVStation= CBSSN

}}

• Sources:{{cite web|title=GAME NOTES: C-USA Opener Charlotte vs. Middle Tennessee|url=https://charlotte49ers.com/news/2021/9/21/football-game-notes-c-usa-opener-charlotte-vs-middle-tennessee.aspx|website=Charlotte49ers.com|date=September 21, 2021|access-date=September 25, 2021}}{{cite web|title=Reynolds Caps Record-Breaking Night in Win over Middle Tennessee

|url=https://charlotte49ers.com/news/2021/9/25/football-reynolds-caps-record-breaking-night-in-win-over-middle-tennessee.aspx |date=September 25, 2021|access-date=September 25, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Middle Tenn. Vs Charlotte (Sept 24, 2021 at Charlotte, N.C.)|url=https://charlotte49ers.com/documents/2021/9/24/Middle_Tennessee_at_Charlotte_Game_Book.PDF|access-date=September 25, 2021}}{{cite web|title=Middle Tenn. vs Charlotte – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282204|work=ESPN|date=September 24, 2021|access-date=September 25, 2021}}{{cite news|title=The Charlotte 49ers’ offense exploded in conference opener against Middle Tennessee|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article254492607.html|newspaper=The Charlotte Observer|date=September 24, 2021|access-date=September 25, 2021}}{{cite web|title=TPA:C-USA Opener – Charlotte 42 Middle Tennessee 39|url=https://charlotte49ers.com/news/2021/9/25/football-the-point-after-c-usa-opener-charlotte-42-middle-tennessee-39.aspx|website=Charlotte49ers.com|date=September 25, 2021|access-date=September 26, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=7:25|Team=CHAR|Event=

Grant DUBOSE 17 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7–0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=3:27|Team=MTSU|Event=Jimmy MARSHALL 7 Yd pass from Chase CUNNINGHAM (Zeke RANKIN Kick)|Score=TIED 7–7}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=0:57|Team=CHAR|Event=Grant DUBOSE 12 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 14–7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=11:15|Team=MTSU|Event=Jaylin LANE 24 Yd pass from Chase CUNNINGHAM (Zeke RANKIN Kick)|Score=TIED 14–14}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=7:49|Team=MTSU|Event=Zeke RANKIN 26 Yd Field Goal|Score=MTSU 17–14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=7:04|Team=CHAR|Event=Elijah SPENCER 18 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 21–17}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=6:16|Team=MTSU|Event=DJ ENGLAND-CHISOLM 51 Yd pass from Chase CUNNINGHAM (Zeke RANKIN Kick)|Score=MTSU 24–21}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=0:00|Team=CHAR|Event=Calvin CAMP 44 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 28–24}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=10:27|Team=CHAR|Event=Shadrick BYRD 19 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 35–24}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=8:21|Team=MTSU|Event=Jarrin PIERCE 16 Yd pass from Chase CUNNINGHAM (Chase CUNNINGHAM Pass to Jaylin LANE for Two-Point Conversion)|Score=CHAR 35–32}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=4:00|Team=CHAR|Event=Chris REYNOLDS 1 Yd run (Jonathan CRUZ kick)|Score=CHAR 42–32}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=2:12|Team=MTSU|Event=Yusuf ALI 12 Yd pass from Chase CUNNINGHAM (Zeke RANKIN Kick)|Score=CHAR 42–39|LastEntry=yes}}

{{AFB game box end}}

Charlotte would score first only to have Middle Tennessee tie it up before a go ahead touchdown would again give the 49ers the lead. In the 2nd quarter the Blue Raiders would tie the game up again and take their first lead into halftime off a field goal.

Charlotte and Middle Tennessee would again swap leads in the 3rd quarter with the 49ers up heading into the 4th quarter. The 49ers would stretch their lead to 11 points early in the 4th only to see the Blue Raiders cut the lead down to 3 points after a successful two-point conversion. Charlotte would then tack on another touchdown only to see the Blue Raiders again cut the lead to 3 points with slightly more than 2 minutes left in the game, but Middle Tennessee's on-sides kick attempt would fail and with no time outs left the 49ers were able to take a knee to their 3rd home victory of the season.

Top performers of the game included Middle Tennessee's Chase Cunningham who passed for 379 yards and 5 touchdowns. The 49ers' Chris Reynolds would match Cunningham's touchdown performance with 339 yards of passing with 4 passing touchdowns and a 1 yard rushing touchdown. Charlotte's Calvin Camp had 12 carries for 101 yards and a touchdown. The 49ers' Grant DuBose had 9 receptions for 14 yards and 2 touchdowns.

Game notes:

• Chris Reynold's 4 passing touchdowns in the game moved him past Matt Johnson (42) with 45 career touchdown passes making him the new career passing leader.
• Reynolds also added a rushing touchdown for 5 total touchdowns in the game.
• Reynold's received his 2nd Conference USA Offensive Player of the Week award for the season.
• Grant DuBose (114 receiving), Victor Tucker (108 receiving), and Clavin Camp (101 rushing) all had 100 yard performances in the game.
• 6th game in the series since 2015, (MT 4–2).

{{Clear}}

{{see also|2021 Illinois Fighting Illini football team}}

{{AFB game box start

| Title =Charlotte vs Illinois

| Visitor =49ers

| Host = Fighting Illini

| V1 =7 | V2 =7 | V3 =0 | V4 =0

| H1 =3 | H2 =7 | H3 =14 | H4 =0

| Date = October 2

| Location = Memorial Stadium (Champaign)
Champaign, IL

| TimeZone=CDT

| StartTime = 11:01 p.m.

| ElapsedTime = 3:02

| Attendance = 30,559

| Weather = {{Convert|73|°F|°C}} • Weather: Cloudy • Wind: SE 5 MPH

| Referee = Reggie Smith

|TVAnnouncers= Chris Vosters, Stanley Jackson, Krystle Rich

|TVStation= BTN

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte at Illinois|url=https://charlotte49ers.com/news/2021/9/28/football-game-notes-charlotte-at-illinois.aspx|date=September 28, 2021|access-date=September 28, 2021}}{{cite web|title=Second Half Surge Carries Illini Past Charlotte, 24-14|url=https://charlotte49ers.com/news/2021/10/2/football-second-half-surge-carries-illini-past-charlotte-24-14.aspx|date=October 2, 2021|access-date=October 4, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte Vs Illinois (Oct 02, 2021 at Champaign, Illinois)|url=https://charlotte49ers.com/documents/2021/10/2/Charlotte_at_Illinois_Game_Book.PDF|access-date=October 4, 2021}}{{cite web|title=Charlotte vs Illinois – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282219|work=ESPN|date=October 2, 2021|access-date=October 4, 2021}}{{cite news|title=Charlotte runs aground against Illinois: How the Illini held off the 49ers|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article254649737.html|newspaper=The Charlotte Observer|date=October 4, 2021|access-date=October 4, 2021}}{{cite web|title=TPA:Charlotte at Illinois|url=https://charlotte49ers.com/news/2021/10/3/football-the-point-after-charlotte-at-illinois.aspx|website=Charlotte49ers.com|date=October 3, 2021|access-date=October 4, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=7:28|Team=ILLI|Event=

James MCCOURT 29 Yd Field Goal|Score=ILLI 3-0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=1:31|Team=CHAR|Event=Victor TUCKER 22 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=2:52|Team=ILLI|Event=Daniel BARKER 10 Yd pass from Brandon PETERS (James MCCOURT Kick)|Score=ILLI 10-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=0:46|Team=CHAR|Event=Elijah SPENCER 27 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 14-10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=6:52|Team=ILLI|Event=Chase BROWN 31 Yd Run (James MCCOURT Kick)|Score=ILLI 17-14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=0:00|Team=ILLI|Event=Chase BROWN 80 Yd Run (James MCCOURT Kick)|Score=ILLI 24-14|LastEntry=yes}}

{{AFB game box end}}

The game got off to a slow start with the Illini making a field goal halfway through the first quarter and Charlotte answering with a touchdown right before the second quarter. The Illini would finally find the endzone with less than three minutes left in the half only to have the 49ers answer with a touchdown of their on to take a 14 to 10 lead into the halftime.

The Illini would retake the lead midway through the third quarter. Charlotte would get into comfortable field goal range in the last seconds of the quarter to attempt to tie the game only to have the ball drift wide right. On the next play from scrimmage the Illini would tack on an 80 yard touchdown run. The Illini would then use ball control running plays to eat up the clock and walk away with a 24 to 14 home victory.

Top performances of the game included Charlotte's Chris Reynolds, who threw for 191 yards, two touchdowns and an interception. The Fighting Illini's Chase Brown had 26 carries for 257 yards and two touchdowns. The 49ers' Grant DuBose had four receptions for 70 yards.

Game notes:

• First 49ers game in the State of Illinois.
• First game against a Big Ten Conference opponent.
• First time the 49ers have played two Power 5 conference teams in a single season.
• Chris Reynolds became the first 49ers passer to cross the 6000 yards mark.
• Victor Tucker moved into a 2nd place tie with Trent Bostick for career touchdown receptions with 12.
• First game in series history.

{{Clear}}

{{see also|2021 FIU Panthers football team}}

{{AFB game box start

| Title =Charlotte vs FIU

| Visitor =49ers

| Host =Panthers

| V1 =7 | V2 =10 | V3 =14 | V4 =14

| H1 =3 | H2 =3 | H3 =7 | H4 =20

| Date = October 8

| Location = Riccardo Silva Stadium
Miami, FL

| TimeZone=EDT

| StartTime = 7:03 pm

| ElapsedTime = 3:36

| Attendance = 0

| Weather = {{Convert|82|°F|°C}} • Weather: Cloudy • Wind: 0 MPH

| Referee = Joe Lehring

|TVAnnouncers= Chris Lewis, Donte Whitner

|TVStation= CBSSN

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte Heads to FIU for Key C-USA Match-Up|url=https://charlotte49ers.com/news/2021/10/6/football-game-notes-charlotte-heads-to-fiu-for-key-c-usa-match-up.aspx|date=October 6, 2021|access-date=October 7, 2021}}{{cite web|title=Niners Explode for Six TDs; Take Down FIU on the Road|url=https://charlotte49ers.com/news/2021/10/9/football-niners-explode-for-six-tds-take-down-fiu-on-the-road.aspx|date=October 9, 2021|access-date=October 9, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte Vs FIU (Oct 08, 2021 at Miami, Florida)|url=https://charlotte49ers.com/documents/2021/10/8/Charlotte_at_FIU_Game_Book.PDF|access-date=October 9, 2021}}{{cite web|title=Charlotte vs FIU – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282224|work=ESPN|date=October 8, 2021|access-date=October 8, 2021}}{{cite news|title=The Charlotte 49ers are off to the program’s best start after a win at FIU|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article254858627.html#storylink=mainstage_lead|newspaper=The Charlotte Observer|date=October 8, 2021|access-date=October 8, 2021}}{{cite web|title=TPA:Charlotte 45 at FIU 33 - Charlotte Unbeaten in C-USA|url=https://charlotte49ers.com/news/2021/10/9/football-the-point-after-charlotte-45-at-fiu-33-charlotte-unbeaten-in-c-usa.aspx|website=Charlotte49ers.com|date=October 9, 2021|access-date=October 10, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=8:59|Team=FIU|Event=Chase GABRIEL 26 Yd Field Goal|Score=FIU 3-0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=5:15|Team=CHAR|Event=Calvin CAMP 2 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 7-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=9:21|Team=CHAR|Event=Taylor THOMPSON 5 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 14-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=4:49|Team=FIU|Event=Chase GABRIEL 43 Yd Field Goal|Score=CHAR 14-6}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=0:03|Team=CHAR|Event=Jonathan CRUZ 42 Yd Field Goal|Score=CHAR 17-6}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=11:58|Team=CHAR|Event=Victor TUCKER 22 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 24-6}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=11:25|Team=FIU|Event=Kris MITCHELL 50 Yd pass from Max BORTENSCHLAGER (Chase GABRIEL Kick)|Score=CHAR 24-13}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=3:46|Team=CHAR|Event=Jake CLEMONS 1 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 31-13}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=11:10|Team=FIU|Event=Tyrese CHAMBERS 59 Yd pass from Max BORTENSCHLAGER (Chase GABRIEL Kick)|Score=CHAR 31-20}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=5:45|Team=CHAR|Event=Jonathan ALEXANDER 41 Yd Interception Return (Jonathan CRUZ Kick)|Score=CHAR 38-20}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=5:35|Team=FIU|Event=Tyrese CHAMBERS 75 Yd pass from Max BORTENSCHLAGER (Chase GABRIEL Kick)|Score=CHAR 38-27}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=2:36|Team=CHAR|Event=Ryan CARRIERE 4 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 45-27}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=0:14|Team=FIU|Event=Sterling PALMER 8 Yd pass from Max BORTENSCHLAGER (Chase GABRIEL PAT failed)|Score=CHAR 45-33|LastEntry=yes}}

{{AFB game box end}}

The game Started slow with Charlotte answering FIU's field goal with a touchdown. The 49ers would pad their lead in the 2nd quarter with another touchdown before both teams traded field goals before the half. Charlotte hit the locker rooms with a 17 to 6 lead.

Charlotte would stretch the lead out to 18 early in the 2nd half, but two plays later FIU would find the endzone for the first time in the game. Charlotte would go back out to an 18 point lead before the start of the last quarter with a 21 to 3 lead.

Both teams would score as many touchdowns in the 4th quarter as they had in the entire rest of the game combined. FIU would pull back to within 11 points early in the quarter. With less than six minutes left on the clock the 49ers again would go out to an 18 point lead on a Jon Alexander interception return, only to have the Panthers score on the very next play. The Panthers looked like they might have recovered the ensuing on-sides kick, but the ball didn't cross the 10 yard mark by mere inches. The 49ers would capitalize on the turnover and again reach the magic number 18 with less than 3 minutes on the clock. FIU would get it to within 12 points with less than 15 seconds on the clock, but the on-sides kick attempt this time was easily recovered by the 49ers who would leave Miami with a 45 to 33 win.

Both quarterbacks, Charlotte's Chris Reynolds and FIU's Matt Bortenschlager, put up four touchdowns passes each, Reynolds for 203 yards and Bortenschlager for an impressive 466 yards and an interception. FIU's D'vonte Price rushed for 89 yards on 18 carries. The Panthers' Tyrese Chambers had 3 receptions for 201 yards and two touchdowns.

Game notes:

• First victory for Charlotte over FIU, who was the last team in CUSA's Eastern Division that Charlotte had never defeated.
• Shadrick Byrd was named Conference USA Special Teams Player of the Week.
• 6th game in the series since 2015, (FIU 5–1).

{{Clear}}

{{see also|2021 Florida Atlantic Owls football team}}

{{AFB game box start

| Title =Florida Atlantic vs Charlotte

| Visitor =Owls

| Host =49ers

| V1 =0 | V2 =7 | V3 =21 | V4 =10

| H1 =3 | H2 =6 | H3 =0 | H4 =0

| Date = October 21

| Location = Jerry Richardson Stadium
Charlotte, NC

| TimeZone=EDT

| StartTime = 7:32 pm

| ElapsedTime = 3:12

| Attendance = 13,017

| Weather = {{Convert|73|°F|°C}} • Weather: Cloudy • Wind: SW 10 MPH

| Referee = Kevin Randall

|TVAnnouncers= Jason Horowitz, Ross Tucker

|TVStation= CBSSN

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte vs. Florida Atlantic|url=https://charlotte49ers.com/news/2021/10/19/football-game-notes-charlotte-vs-florida-atlantic.aspx|date=October 19, 2021|access-date=October 24, 2021}}{{cite web|title=Charlotte's Home Win Streak Stifled by Owls, Thursday|url=https://charlotte49ers.com/news/2021/10/22/football-charlottes-home-win-streak-stifled-by-owls-thursday.aspx|date=October 22, 2021|access-date=October 24, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Florida Atlantic vs Charlotte (Oct 21, 2021 at Charlotte, N.C.)|url=https://charlotte49ers.com/documents/2021/10/21/Florida_Atlantic_at_Charlotte_Game_Book.PDF|access-date=October 24, 2021}}{{cite web|title=Charlotte vs Florida Atlantic – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282235|work=ESPN|date=October 21, 2021|access-date=October 24, 2021}}{{cite news|title=Big FAU second half dooms Charlotte as the 49ers fall to the Owls at home|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article255106177.html|newspaper=The Charlotte Observer|date=October 22, 2021|access-date=October 24, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=3:19|Team=CHAR|Event=Jonathan CRUZ 23 Yd Field Goal|Score=CHAR 3-0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=12:32|Team=FAU|Event=TJ CHASE 8 Yd pass from N'Kosi PERRY (Aaron SHAHRIARI Kick)|Score=FAU 7-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=0:00|Team=CHAR|Event=Grant DUBOSE 1 Yd pass from Chris REYNOLDS (Jonathan CRUZ PAT failed)|Score=CHAR 9-7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=13:38|Team=FAU|Event=Johnny FORD 32 Yd pass from N'Kosi PERRY (Aaron SHAHRIARI Kick)|Score=FAU 14-9}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=7:11|Team=FAU|Event=Malcolm DAVIDSON 9 Yd Run (Aaron SHAHRIARI Kick)|Score=FAU 21-9}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=1:06|Team=FAU|Event=Brandon ROBINSON 30 Yd pass from N'Kosi PERRY (Aaron SHAHRIARI Kick)|Score=FAU 28-9}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=9:09|Team=FAU|Event=Aaron SHAHRIARI 27 Yd Field Goal|Score=FAU 31-9}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=7:14|Team=FAU|Event=Johnny FORD 1 Yd Run (Aaron SHAHRIARI Kick)|Score=FAU 38-9|LastEntry=yes}}

{{AFB game box end}}

Both teams, coming off bye weeks, would start the game slowly with Charlotte parting the uprights in the first quarter and FAU getting the first touchdown near the end of the second quarter. With no time left in the half Charlotte would find the endzone to take a lead into the locker rooms at halftime, but the rare missed PAT from Jonathan Cruz would seem to be a harbinger of what was to come in the second half for the 49ers.

FAU would retake the lead on the first series of the second half and never look back. They would add two more touchdowns before the fourth quarter and pad their lead in the final quarter with a field goal and a final touchdown to win 38 to 9.

Top performers of the game included Florida Atlantic quarterback N'Kosi Perry, who threw for 225 yards and three touchdowns. The Owls' Johnny Ford rushed for 92 yards on 8 carries with a touchdown. Charlotte's Victor Tucker had 6 receptions for 105 yards.

Game notes:

• 7th game in the series since 2015, (FAU 5–2).

{{Clear}}

{{see also|2021 Western Kentucky Hilltoppers football team}}

{{AFB game box start

| Title =Charlotte vs Western Kentucky

| Visitor =49ers

| Host =Hilltoppers

| V1 =3 | V2 =10 | V3 =0 | V4 =0

| H1 =14 | H2 =14 | H3 =7 | H4 =10

| Date = October 30

| Location = Houchens Industries-L. T. Smith Stadium
Bowling Green, KY

| TimeZone=EDT

| StartTime = 4:05 pm

| ElapsedTime = 3:11

| Attendance = 16,763

| Weather = {{Convert|55|°F|°C}} • Weather: Rainy • Wind: 0 MPH

| Referee = Scott Hardin

|TVAnnouncers= Nate Gatter, Bob Belvin

|TVStation= ESPN+

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte at WKU |url=https://charlotte49ers.com/news/2021/10/27/football-game-notes-charlotte-at-wku.aspx|date=October 27, 2021|access-date=October 27, 2021}}{{cite web|title=WKU Pulls Away From Charlotte in C-USA East Division Action|url=https://charlotte49ers.com/news/2021/10/30/football-wku-pulls-away-from-charlotte-in-c-usa-east-division-action.aspx|date=October 30, 2021|access-date=November 2, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte vs WKU (Oct 30, 2021 at Bowling Green, Ky.)|url=https://charlotte49ers.com/documents/2021/10/31/Charlotte_at_WKU_Game_Book.pdf|access-date=November 2, 2021}}{{cite web|title=Charlotte vs Western Kentucky – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282241|work=ESPN|date=October 30, 2021|access-date=November 2, 2021}}{{cite news|title=The Charlotte 49ers’ slide continues in a tough loss to Western Kentucky|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article255416531.html|newspaper=The Charlotte Observer|date=October 30, 2021|access-date=November 2, 2021}}{{cite web|title=TPA:Charlotte at WKU|url=https://charlotte49ers.com/news/2021/10/31/football-the-point-after-charlotte-at-wku.aspx|website=Charlotte49ers.com|date=October 31, 2021|access-date=November 2, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=11:44|Team=WKU|Event=Daewood DAVIS 11 Yd pass from Bailey Zappe (Brayden NARVESON Kick)|Score=WKU 7-0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=6:39|Team=CHAR|Event=Jonathan CRUZ 37 Yd Field Goal|Score=WKU 7-3}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=1:21|Team=WKU|Event=Bailey ZAPPE 2 Yd Run (Brayden NARVESON Kick)|Score=WKU 17-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=13:09|Team=WKU|Event=Mitchell TINSLEY 13 Yd pass from Bailey ZAPPE (Brayden NARVESON Kick)|Score=WKU 21-3}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=9:40|Team=CHAR|Event=James FOSTER 1 Yd Run (Jonathan CRUZ Kick)|Score=WKU 21-10}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=3:06|Team=CHAR|Event=Jonathan CRUZ 56 Yd Field Goal|Score=WKU 21-13}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=1:27|Team=WKU|Event=Jerreth Sterns 21 Yd pass from Bailey ZAPPE (Brayden NARVESON Kick)|Score=WKU 28-13}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=2:04|Team=WKU|Event=Dalvin SMITH 9 Yd pass from Bailey ZAPPE (Brayden NARVESON Kick)|Score=WKU 35-13}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=12:28|Team=WKU|Event=Brayden NARVESON 35 Yd Field Goal|Score=WKU 38-13}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=5:09|Team=WKU|Event=Noah WHITTINGTON 1 Yd Run (Brayden NARVESON Kick)|Score=WKU 45-13|LastEntry=yes}}

{{AFB game box end}}

In a light rain the 49ers struggled behind backup quarterback James Foster to establish an offensive rhythm. This was not an issue WKU had as they scored first in the game and already had 4 touchdowns before the half. Charlotte would split the uprights twice and find the endzone once to keep the game within reach heading into the locker rooms, 28 to 13.

The second half would be significantly less active, but it was all Hilltoppers, adding two more touchdowns and a field goal to put the game safely in their pocket. The final score was WKU 45, Charlotte 13.

Top performances of the game were dominated by the Hilltopper's, whose Bailey Zappe threw for 393 yards, 4 touchdowns and 2 interceptions on his way to collecting a CUSA Offensive Player of the Week Award. Noah Whittingham rushed for 66 yards on 10 carries for a touchdown. Jerreth Sterns had 10 receptions for 89 yards and a touchdown.

Game notes:

• Jonathan Cruz's 56 yard field goal tied his own school record.
• The 56 yard field goal also matched the season longest NCAA field goal up to that point in the season.
• 5th game in the series since 2017, (WKU 4–1).

{{Clear}}

{{see also|2021 Rice Owls football team}}

{{AFB game box start

| Title =Rice vs Charlotte

| Visitor =Owls

| Host =49ers

| V1 =0 | V2 =7 | V3 =10 | V4 =7 | VOT =0

| H1 =7 | H2 =7 | H3 =0 | H4 =10 | HOT =7

| Date = November 6

| Location = Jerry Richardson Stadium
Charlotte, NC

| TimeZone=EDT

| StartTime = 3:35 pm

| ElapsedTime = 3:30

| Attendance = 16,050

| Weather = {{Convert|56|°F|°C}} • Weather: Cloudy • Wind: S 15 MPH

| Referee = Kevin Randall

|TVAnnouncers= Bobby Rosinski, Reggie Walker Jr.

|TVStation= ESPN+

}}

• Sources:{{cite web|title=HOMECOMING GAME NOTES: Charlotte vs. Rice |url=https://charlotte49ers.com/news/2021/11/4/football-homecoming-game-notes-charlotte-vs-rice.aspx|date=November 4, 2021|access-date=November 4, 2021}}{{cite web|title=Homecoming Heroics! Niners Rally for OT Win|url=https://charlotte49ers.com/news/2021/11/6/football-homecoming-heroics-niners-rally-for-ot-win.aspx|date=November 6, 2021|access-date=November 7, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Rice vs Charlotte (Nov 6, 2021 at Charlotte, NC.)|url=https://charlotte49ers.com/documents/2021/11/6/Rice_at_Charlotte_Game_Book.PDF|access-date=November 7, 2021}}{{cite web|title=Rice vs Charlotte – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282247|work=ESPN|date=November 6, 2021|access-date=November 7, 2021}}{{cite news|title=Charlotte 49ers back on the right track after a thrilling comeback win over Rice in OT|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article255603611.html|newspaper=The Charlotte Observer|date=November 6, 2021|access-date=November 7, 2021}}{{cite web|title=TPA:Charlotte 31 Rice 24 (OT)|url=https://charlotte49ers.com/news/2021/11/7/football-the-point-after-charlotte-31-rice-24-ot.aspx|website=Charlotte49ers.com|date=November 7, 2021|access-date=November 7, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=4:37|Team=CHAR|Event=Calvin CAMP 53 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7-0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=11:29|Team=RICE|Event=Ari BROUSSARD 22 Yd Run (Christian VANSICKLE Kick)|Score=TIED 7-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=7:49|Team=CHAR|Event=Shadrick BYRD 1 Yd Run (Jonathan CRUZ Kick)|Score=CHAR 14-7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=8:01|Team=RICE|Event=Christian VANSICKLE 25 Yd Field Goal|Score=CHAR 14-10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=2:48|Team=RICE|Event=Jordan MYERS 1 Yd Run (Christian VANSICKLE Kick)|Score=RICE 17-14}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=6:35|Team=RICE|Event=Ari BROUSSARD 2 Yd Run (Christian VANSICKLE Kick)|Score=RICE 24-14}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=4:09|Team=CHAR|Event=Jonathan CRUZ 32 Yd Field Goal|Score=RICE 24-17}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=1:14|Team=CHAR|Event=Elijah SPENCER 8 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=TIED 24-24}}

{{AFB Game Box Scoring Entry|Quarter=OT|Time=OT|Team=CHAR|Event=Elijah SPENCER 25 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 31-24|LastEntry=yes}}

{{AFB game box end}}

Charlotte scored first on the windy afternoon in the first quarter. Rice would answer early in the 2nd quarter to tie it up but mid-way through that quarter the 49ers would again find the endzone to take a 14 to 7 lead in at the half.

Rice split the uprights midway through the 3rd quarter after the 49ers turned it over in the redzone. Rice would take their first lead of the game late in the third quarter and early in the fourth quarter would extended it to a two score lead. The 49ers again would find the redzone but would be forced to settle for a field goal to get it back down to a one score game. With less than a minute and a half left in regulation Chris Reynolds would find Elijah Spencer in the corner of the endzone to tie the game for the second time. Rice would go 4 and out and Charlotte would take their chances in overtime.

Charlotte took possession first in the overtime and on the first play Reynolds again would find Spencer to take a 7 point lead. On their second play of the overtime Rice's Jake Constantine would be flushed from the pocket and throw up a game winning interception to Charlotte's Luke Martin, securing the overtime win for the 49ers at 31 to 24.

Top performances of the game included Charlotte's Chris Reynolds, who threw for 292 yards and 3 touchdowns. Rice's Ari Broussard had 20 carries for 186 yards and 2 touchdowns. The 49ers' Elijah Spencer had 6 receptions for 77 yards and 2 touchdowns.

Game notes:

• 49th home game at Richardson Stadium for the 49ers.
• 49th Conference USA game for the 49ers.
• First overtime game for the 49ers since the 2017 season.
• 3rd game in the series since 2015, (Rice 2–1).

{{Clear}}

{{see also|2021 Louisiana Tech Bulldogs football team}}

{{AFB game box start

| Title =Charlotte vs Louisiana Tech

| Visitor =49ers

| Host =Bulldogs

| V1 =0 | V2 =7 | V3 =10 | V4 =15

| H1 =7 | H2 =7 | H3 =14 | H4 =14

| Date = November 13

| Location = Joe Aillet Stadium
Ruston, LA

| TimeZone=EST

| StartTime = 3:36 pm

| ElapsedTime = 3:30

| Attendance = 14,068

| Weather = {{Convert|58|°F|°C}} • Weather: Sunny • Wind: 0 MPH

| Referee = Ed Ardito

|TVAnnouncers= Chris Hassel, Sed Bonner

|TVStation= Stadium

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte at Louisiana Tech on WCCB-TV |url=https://charlotte49ers.com/news/2021/11/11/football-game-notes-charlotte-at-louisiana-tech.aspx|date=November 11, 2021|access-date=November 15, 2021}}{{cite web|title=Charlotte Drops High-Scoring Battle at Louisiana Tech|url=https://charlotte49ers.com/news/2021/11/13/football-charlotte-drops-high-scoring-battle-at-louisiana-tech.aspx|date=November 13, 2021|access-date=November 15, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte vs Louisiana Tech (Nov 13, 2021 at Ruston, LA)|url=https://charlotte49ers.com/documents/2021/11/13/Charlotte_at_Louisiana_Tech_Game_Book.PDF|access-date=November 15, 2021}}{{cite web|title=Charlotte vs Louisiana Tech – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282254|work=ESPN|date=November 13, 2021|access-date=November 15, 2021}}{{cite news|title=Charlotte 49ers’ road woes continue under coach Will Healy with loss to Louisiana Tech|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article255801406.html|newspaper=The Charlotte Observer|date=November 13, 2021|access-date=November 15, 2021}}{{cite web|title=TPA:Charlotte at Louisiana Tech|url=https://charlotte49ers.com/news/2021/11/14/football-the-point-after-charlotte-at-louisiana-tech.aspx|website=Charlotte49ers.com|date=November 15, 2021|access-date=November 14, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=3:16|Team=LTECH|Event=Marcus WILLIAMS Jr. 2 Yd Run (Jacob BARNES Kick)|Score=LTECH 7-0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=5:55|Team=CHAR|Event=Shadrick BYRD 1 Yd Run (Jonathan CRUZ Kick)|Score=TIED 7-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=1:38|Team=LTECH|Event=Marcus WILLIAMS Jr. 8 Yd Run (Jacob BARNES Kick)|Score=LTECH 14-7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=12:58|Team=LTECH|Event=Marcus WILLIAMS Jr. 6 Yd Run (Jacob BARNES Kick)|Score=LTECH 21-7}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=9:06|Team=CHAR|Event=Jonathan CRUZ 26 Yd Field Goal|Score=LTECH 21-10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=7:22|Team=LTECH|Event=Isaiah GRAHAM 32 Yd pass from Aaron ALLEN (Jacob BARNES Kick)|Score=LTECH 28-10}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=3:52|Team=CHAR|Event=Chris REYNOLDS 12 Yd Run (Jonathan CRUZ Kick)|Score=LTECH 28-17}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=13:36|Team=LTECH|Event=Smoke HARRIS 17 Yd pass from Aaron ALLEN (Jacob BARNES Kick)|Score=LTECH 35-17}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=12:18|Team=CHAR|Event=Keith PEARSON 18 Yd pass from Chris REYNOLDS (Chris REYNOLDS Pass to Keith PEARSON |Score=LTECH 35-25}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=11:06|Team=LTECH|Event=Marcus WILLIAMS Jr. 25 Yd Run (Jacob BARNES Kick)|Score=LTECH 42-25}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=8:44|Team=CHAR|Event=Keith PEARSON 21 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=LTECH 42-32|LastEntry=yes}}

{{AFB game box end}}

In the first ever match between these conference foes the Louisiana Tech Bulldogs, already eliminated from bowl contention, got to play spoiler to the 49ers who were still seeking their second bowl qualification in program history.

The game started slow with the Bulldogs taking the early lead at home, but the 49ers would tie the game up before the Bulldogs would score again to take a 14 to 7 lead into the half.

Once again Charlotte experienced a second half change in pace as the Bulldogs early in the third quarter took a commanding two score lead. The 49ers would gain a field goal and a touchdown in the quarter but La. Tech would also find the end zone again to preserve a two score lead heading into the last quarter of play. Charlotte would add two more touchdowns in the fourth quarter but so would the Bulldogs who would win the battle at home to the score of 42 to 32, denying Charlotte a bowl qualification for at least another week and continuing Charlotte's road winless tour.

Top performances for the game included Charlotte's Chris Reynolds, who threw for 448 yards with 2 touchdowns and an interception. The Bulldogs' Marcus Williams Jr. rushed for 131 yards on 29 carries with 4 touchdowns. The 49ers' Keith Pearson had 6 receptions for 150 yards and 2 touchdowns.

Game notes:

• First time the 49ers will visit the State of Louisiana.
• First time these two cross-division conference mates will meet.
• Chris Reynold's 448 passing yards set a new school single-game record.
• Reynold's became the first 49ers' passer to cross 7,000 career passing yards.
• Louisiana Tech is the final team in Conference USA the 49ers have yet to play.

{{Clear}}

{{see also|2021 Marshall Thundering Herd football team}}

{{AFB game box start

| Title =Marshall vs Charlotte

| Visitor =Thundering Herd

| Host =49ers

| V1 =7 | V2 =14 | V3 =21 | V4 =7

| H1 =7 | H2 =7 | H3 =0 | H4 =14

| Date = November 20

| Location = Jerry Richardson Stadium
Charlotte, NC

| TimeZone=EST

| StartTime = 3:37 pm

| ElapsedTime = 3:14

| Attendance = 13,211

| Weather = {{Convert|54|°F|°C}} • Weather: Sunny • Wind: S 3 MPH

| Referee = Patrick Foy

|TVAnnouncers= Josh Appel, Patrick Russell

|TVStation= Stadium

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte vs. Marshall: All-Time Game No. 100 |url=https://charlotte49ers.com/news/2021/11/17/football-game-notes-charlotte-vs-marshall-the-100th-game.aspx|date=November 17, 2021|access-date=November 18, 2021}}{{cite web|title=Charlotte Upended by Marshall in C-USA Action|url=https://charlotte49ers.com/news/2021/11/20/football-charlotte-upended-by-marshall-in-c-usa-action.aspx|date=November 20, 2021|access-date=November 22, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Marshall vs Charlotte(Nov 20, 2021 at Charlotte, NC)|url=https://charlotte49ers.com/documents/2021/11/20/Marshall_at_Charlotte_Game_Book.PDF|access-date=November 20, 2021}}{{cite web|title=Marshall vs Charlotte – Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282261|work=ESPN|date=November 20, 2021|access-date=November 22, 2021}}{{cite news|title=Marshall thunders past Charlotte. What we learned in the 49ers’ loss to the Herd|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article255892151.html|newspaper=The Charlotte Observer|date=November 20, 2021|access-date=November 22, 2021}}{{cite web|title=TPA:Charlotte vs. Marshall|url=https://charlotte49ers.com/news/2021/11/21/football-the-point-after-charlotte-vs-marshall-all-time-game-100.aspx|website=Charlotte49ers.com|date=November 21, 2021|access-date=November 22, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=8:42|Team=CHAR|Event=Keith PEARSON 6 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=CHAR 7-0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=5:14|Team=MARS|Event=Rasheen ALI 25 Yd Run (Shane CIUCCI Kick)|Score=TIED 7-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=12:12|Team=MARS|Event=Rasheen ALI 5 Yd Run (Shane CIUCCI Kick)|Score=MARS 14-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=4:13|Team=CHAR|Event=Cameron DOLLAR 21 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=TIED 14-14}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=3:26|Team=MARS|Event=Corey GAMMAGE 64 Yd pass from Grant Wells (Shane CIUCCI Kick)|Score=MARS 21-14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=11:49|Team=MARS|Event=Xavier GAINES 22 Yd pass from Grant WELLS (Shane CIUCCI Kick)|Score=MARS 28-14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=7:45|Team=MARS|Event=Sheldon EVANS 15 Yd Run (Shane CIUCCI Kick)|Score=MARS 35-14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=2:07|Team=MARS|Event=Rasheen ALI 4 Yd Run (Shane CIUCCI Kick)|Score=MARS 42-14}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=11:37|Team=CHAR|Event=Cameron DOLLAR 4 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=MARS 42-21}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=8:36|Team=MARS|Event=Sheldon EVANS 25 Yd Run (Shane CIUCCI Kick)|Score=MARS 49-21}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=4:33|Team=CHAR|Event=ChaVon MCEACHERN 5 Yd pass from James FOSTER (Jonathan CRUZ Kick)|Score=MARS 49-28|LastEntry=yes}}

{{AFB game box end}}

Charlotte would find the endzone first to take the early lead before Marshall would tie the game going into the second quarter. The Herd would take the lead early in the second quarter before the 49ers would again tie the score before a late Marshall touchdown let them take a 21 to 14 lead in at the half.

Charlotte's second half woes would again plague the team as Marshall rattled off three third quarter touchdowns, and their fourth touchdown in a row, before the Niners could answer early in the fourth quarter. The teams would exchange two more touchdowns to end the game behind both teams' second string quarterbacks but the game was effectively over in the third quarter with Marshall winning 49 to 28.

Top performers of the game included Charlotte's Chris Reynolds, who threw for 178 yards with 3 touchdowns and an interception on his way to setting a new program single season touchdown record. Marshall's Rasheen Ali rushed for 203 yards on 23 carries for 3 touchdowns. The Herds' Corey Gammage had 3 receptions for 78 yards and a touchdown

Game notes:

• 100th game in Charlotte program history.
• Chris Reynold's 3 touchdown passes in the game broke his own single season touchdown record (24 vs 22).
• 6th game in the series since 2015, (Mar. 4–2).

{{Clear}}

{{see also|2021 Old Dominion Monarchs football team}}

{{AFB game box start

| Title =Charlotte vs Old Dominion

| Visitor =49ers

| Host =Monarchs

| V1 =0 | V2 =14 | V3 =14 | V4 =6

| H1 =14 | H2 =14 | H3 =7 | H4 =21

| Date = November 27

| Location = S.B. Ballard Stadium
Norfolk, VA

| TimeZone=EST

| StartTime = 2:05 pm

| ElapsedTime = 3:48

| Attendance = 15,874

| Weather = {{Convert|45|°F|°C}} • Weather: Sunny • Wind: 0 MPH

| Referee = Kevin Randall

|TVAnnouncers= Ted Alexander, Andy Mashaw, James Witham

|TVStation= ESPN+

}}

• Sources:{{cite web|title=GAME NOTES: Charlotte vs. Marshall: All-Time Game No. 100 |url=https://charlotte49ers.com/news/2021/11/23/football-game-notes-charlotte-at-old-dominion.aspx|date=November 23, 2021|access-date=November 29, 2021}}{{cite web|title=Charlotte Fights Back Before Dropping Season Finale at ODU|url=https://charlotte49ers.com/news/2021/11/27/football-charlottes-second-half-fight-not-enough-at-odu.aspx|date=November 27, 2021|access-date=November 29, 2021}}{{cite web|title=Scoring Summary Report 2021 Charlotte Football, Charlotte vs Old Dominion(Nov 27, 2021 at Norfolk, VA)|url=https://charlotte49ers.com/documents/2021/11/27/Charlotte_at_Old_Dominion_Game_Book.PDF|access-date=November 27, 2021}}{{cite web|title=Charlotte vs Old Dominion– Game Summary|url=https://www.espn.com/college-football/game/_/gameId/401282268|work=ESPN|date=November 27, 2021|access-date=November 29, 2021}}{{cite news|title=Charlotte isn’t going bowling this year. What we learned from the 49ers’ loss to ODU|first=Hunter|last=Bailey|url=https://www.charlotteobserver.com/sports/college/charlotte-49ers/article256162827.html|newspaper=The Charlotte Observer|date=November 27, 2021|access-date=November 29, 2021}}{{cite web|title=TPA:Charlotte at Old Dominion|url=https://charlotte49ers.com/news/2021/11/29/football-the-point-after-charlotte-at-old-dominion.aspx|website=Charlotte49ers.com|date=November 29, 2021|access-date=December 2, 2021}}

{{AFB Game Box Scoring Entry|FirstEntry=yes|Quarter=1|Time=9:15|Team=ODU|Event=Nick Saldiveri 0 Yd Run (Nick RICE Kick)|Score=ODU 7-0}}

{{AFB Game Box Scoring Entry|Quarter=1|Time=2:51|Team=ODU|Event=Elijah DAVIS 12 Yd Run (Nick RICE Kick)|Score=ODU 14-0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=12:11|Team=ODU|Event=Ali JENNINGS III 46 Yd pass from Hayden WOLFF (Nick RICE Kick)|Score=ODU 21-0}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=10:45|Team=CHAR|Event=Elijah SPENCER 19 Yd pass from Chris REYNOLDS (Jonathan CRUZ Kick)|Score=ODU 21-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=7:40|Team=ODU|Event=Ali JENNINGS III 34 Yd pass from Hayden WOLFF (Nick RICE Kick)|Score=ODU 28-7}}

{{AFB Game Box Scoring Entry|Quarter=2|Time=2:59|Team=CHAR|Event=Luke MARTIN 8 Yd Interception Return (Jonathan CRUZ Kick)|Score=ODU 28-14}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=10:49|Team=CHAR|Event=Grant DUBOSE 9 Yd pass from Chris REYNOLDS (Jonathan Cruz Kick)|Score=ODU 28-21}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=6:06|Team=CHAR|Event=Calvin CAMP 6 Yd Run (Jonathan CRUZ Kick)|Score=TIED 28-28}}

{{AFB Game Box Scoring Entry|Quarter=3|Time=3:25|Team=ODU|Event=Blake WATSON 3 Yd Run (Nick RICE Kick)|Score=ODU 35-28}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=13:09|Team=CHAR|Event=Jonathan CRUZ 39 Yd Field Goal|Score=ODU 35-31}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=10:04|Team=CHAR|Event=Jonathan CRUZ 44 Yd Field Goal|Score=ODU 35-34}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=6:42|Team=ODU|Event=Blake WATSON 2 Yd Run (Nick RICE Kick)|Score=ODU 42-34}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=3:49|Team=ODU|Event=Ali JENNINGS III 36 Yd pass from Hayden WOLFF (Nick RICE Kick)|Score=ODU 49-34}}

{{AFB Game Box Scoring Entry|Quarter=4|Time=2:52|Team=ODU|Event=Deeve HARRIS 1 Yd Fumble Return (Nick RICE Kick)|Score=ODU 56-34|LastEntry=yes}}

{{AFB game box end}}

Both teams in this contest need the win to become bowl eligible. Old Dominion had turned a 1-6 start into 5 straight wins. Charlotte had lost 4 of 5 after starting the season 4-2. For these two teams on different wave trajectories, this battle was critical to continue their seasons for a bowl game.

After the usual slow start for the 49ers the Monarchs rattled off two 1st quarter touchdowns and started the 2nd quarter with another to take an early commanding lead before Charlotte would find the endzone. ODU would score again before Charlotte's Luke Martin would intercept a batted pass and return it for the 49ers' second score of the game. The Monarchs took a 28 and 14 lead in at the half.

The start of the 2nd half would be Charlotte's turn to score as tow touchdowns in the 3rd quarter tied the game up at 28-all before ODU would tack on a touchdown to retake the lead heading into the final quarter of regulation. Charlotte would get into ODU's half of the field twice early in the 4th quarter but would have to settle for twin Jonathan Cruz field goals to make it a 1 point game, but with less than 7 minutes left in the game ODU would score two offensive touchdowns and return a 49ers' fumble for a third touchdown to win the game 56 to 34.

Old Dominion dominated the top performances of the game with Hayden Wolff throwing fir 328 yards, 3 touchdowns and 2 interceptions. Blake Watson rushed for 106 yards on 18 carries for 2 touchdowns. Ali Jennings III had 9 receptions for 252 yards and 3 touchdowns.

Game notes:

• Charlotte's first time visiting the newly rebuilt S.B. Ballard Stadium.
• Charlotte's 2nd Oyster Bowl, the series is tied 1-1.
• Chris Reynolds set a new single season passing record for the 49ers with 2,684 yards.
• 6th game in the series since 2015, (ODU 4–2).

{{Clear}}

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