2021 San Francisco 49ers season

The 49ers entered free agency with the following:{{cite web|title=49ers Free Agent|url=http://www.spotrac.com/nfl/free-agents/all/san-francisco-49ers/|work=Spotrac|accessdate=January 6, 2021}}

{{main|2021 NFL draft}}

Notes

• San Francisco traded its first-round selection (12th overall), a 2022 first-round selection, a 2022 third-round selection and a 2023 first-round selection to Miami in exchange for a first-round selection (3rd overall).{{Cite web|title=49ers Announce Trade|url=https://www.49ers.com/news/49ers-announce-trade-draft-dolphins|publisher=49ers.com|date=March 26, 2021|access-date=March 26, 2021}}
• San Francisco traded its second-round (43rd overall) and seventh-round (230th overall) selections to Vegas in exchange for a second-round (48th overall) and fourth (121st overall) selections.{{Cite web|title=49ers trade back from No. 43 with Raiders|url=https://ninerswire.usatoday.com/2021/04/30/49ers-trade-back-from-no-43-with-raiders/|publisher=ninerswire.usatoday.com|date=April 30, 2021|access-date=April 30, 2021}}
• San Francisco traded 2 fourth-round selections (117th and 121st overall) to Los Angeles in exchange for a third-round selection (88th overall).{{Cite web|title=49ers trade up in NFL draft, pick Ohio State RB Trey Sermon|url=https://ninerswire.usatoday.com/2021/04/30/49ers-trade-up-in-nfl-draft-pick-ohio-state-rb-trey-sermon/|publisher=ninerswire.usatoday.com|date=April 30, 2021|access-date=April 30, 2021}}
• San Francisco traded Kwon Alexander to New Orleans in exchange for a fifth-round conditional pick and LB Kiko Alonso.{{Cite web|title=49ers Announce Trade|url=https://www.49ers.com/news/49ers-trade-kwon-alexander-to-saints-acquire-kiko-alonso|publisher=49ers.com|date=November 2, 2020|access-date=November 3, 2020|archive-date=February 28, 2021|archive-url=https://web.archive.org/web/20210228225613/https://www.49ers.com/news/49ers-trade-kwon-alexander-to-saints-acquire-kiko-alonso|url-status=dead}}
• San Francisco traded its third-round and 2020 fifth-round selections to Washington in exchange for offensive tackle Trent Williams.{{Cite web|last=Lambert|first=Ivan|date=April 28, 2020|title=Goodbye Trent|url=https://www.si.com/nfl/washingtonfootball/news/goodbye-trent|url-status=live|access-date=January 28, 2021|work=Sports Illustrated Washington Football News, Analysis and More|archive-url=https://web.archive.org/web/20200915144646/https://www.si.com/nfl/washingtonfootball/news/goodbye-trent |archive-date=September 15, 2020 }}
• San Francisco received third-round selections in 2021, 2022, and 2023, as compensation when defensive coordinator Robert Saleh was hired by the New York Jets as head coach{{Cite web|last=Espinoza|first=Alex|date=January 15, 2021|title=49ers' development of Saleh nets two third-round draft picks|url=https://www.nbcsports.com/bayarea/49ers/49ers-development-robert-saleh-nets-two-third-round-draft-picks|access-date=January 16, 2021|work=NBC Sports}} and vice president of player personnel Martin Mayhew was hired by the Washington Football Team as general manager.{{Cite web|last=Chan|first=Jennifer Lee|date=January 22, 2021|title=Washington hires Mayhew as GM; 49ers to get 2023 comp pick|url=https://www.nbcsports.com/bayarea/49ers/washington-hire-martin-mayhew-gm-49ers-get-2023-draft-pick|access-date=January 29, 2021|work=RSN}}{{Cite web|last=Branch|first=Eric|date=January 22, 2021|title=49ers will gain a draft pick by losing executive Martin Mayhew|url=https://www.sfchronicle.com/49ers/article/Report-49ers-will-gain-a-draft-pick-by-losing-15889318.php|access-date=January 29, 2021|work=San Francisco Chronicle}}
• San Francisco lost its 2021 seventh round selection, as Marquise Goodwin reverted from Philadelphia back to San Francisco.{{Cite web|title=49ers lose draft pick as Marquise Goodwin's contract reverts back to SF|url=https://sports.yahoo.com/49ers-lose-draft-pick-marquise-223859714.html|access-date=March 17, 2021|website=sports.yahoo.com|archive-date=April 22, 2022|archive-url=https://web.archive.org/web/20220422230141/https://sports.yahoo.com/49ers-lose-draft-pick-marquise-223859714.html|url-status=dead}}
• San Francisco acquired a seventh round selection (No. 230) and defensive end Jordan Willis from the New York Jets in exchange for a 2022 sixth round selection.{{Cite web|title=49ers Announce Trade|url=https://www.49ers.com/news/49ers-acquire-jordan-willis-trade-jets|publisher=49ers.com|date=October 27, 2020|access-date=October 28, 2020}}

{{NFL final staff

|Year=2021

|TeamName=San Francisco 49ers

|Front Office=

• Co-chairman – Denise DeBartolo York
• Co-chairman – John York
• Chief executive officer – Jed York
• President – Al Guido
• Chief administrative officer and general counsel - Hanna Gordon
• General manager – John Lynch
• Assistant general manager – Adam Peters
• Executive vice president of football operations – Paraag Marathe
• Vice president and senior advisor – Keena Turner
• Director of player personnel – Ran Carthon
• Director of college scouting – Ethan Waugh
• Assistant director of college scouting – Tariq Ahmad
• National scout – Justin Chabot
• Vice president of football administration – Brian Hampton

|Head Coaches=

• Head coach – Kyle Shanahan
• Assistant head coach/tight ends – Jon Embree

|Offensive Coaches=

• Offensive coordinator – Mike McDaniel
• Quarterbacks – Rich Scangarello
• Running backs – Bobby Turner
• Wide receivers – Wes Welker
• Offensive line – Chris Foerster
• Assistant offensive line – Butch Barry
• Assistant offensive line – Zach Yenser
• Offensive passing game specialist – Bobby Slowik
• Offensive quality control – Brian Fleury
• Offensive quality control – Leonard Hankerson

|Defensive Coaches=

• Defensive coordinator – DeMeco Ryans
• Defensive line – Kris Kocurek
• Assistant defensive line – Darryl Tapp
• Linebackers – Johnny Holland
• Defensive pass game specialist/secondary – Cory Undlin
• Safeties – Daniel Bullocks
• Senior defensive assistant/run game specialist – James Bettcher
• Defensive quality control – Andrew Hayes-Stoker
• Defensive quality control – Klay Kubiak

|Special Teams Coaches=

• Special teams coordinator – Richard Hightower
• Assistant special teams – Matthew Harper
• Special teams quality control – August Mangin

|Strength and Conditioning=

• Head strength and conditioning – Dustin Perry
• Assistant strength and conditioning – Aaron Hill and Greg Segrove
• Director, performance monitoring/assistant strength and conditioning – Shea Thompson

}}

{{NFL final roster

|Year=2021

|TeamName=San Francisco 49ers

|Active=53

|Inactive=10

|Exempt=

|FA=

|PS=16

|PS-exempt=2

|unsigned=

|Date=

|Quarterbacks=

{{NFLplayer|10|Jimmy Garoppolo}}

{{NFLplayer| 5|Trey Lance|rookie=y}}

|Running Backs=

{{NFLplayer|49|Trenton Cannon}}

{{NFLplayer|23|JaMycal Hasty}}

{{NFLplayer|44|Kyle Juszczyk|FB}}

{{NFLplayer|25|Elijah Mitchell|rookie=y}}

{{NFLplayer|28|Trey Sermon|rookie=y}}

{{NFLplayer|22|Jeff Wilson|d=American football}}

|Wide Receivers=

{{NFLplayer|11|Brandon Aiyuk}}

{{NFLplayer|17|Travis Benjamin}}

{{NFLplayer|15|Jauan Jennings}}

{{NFLplayer|19|Deebo Samuel}}

{{NFLplayer| 6|Mohamed Sanu}}

{{NFLplayer|81|Trent Sherfield}}

|Tight Ends=

{{NFLplayer|82|Ross Dwelley}}

{{NFLplayer|85|George Kittle}}

{{NFLplayer|89|Charlie Woerner}}

|Offensive Linemen=

{{NFLplayer|65|Aaron Banks|d=American football|G|rookie=y}}

{{NFLplayer|64|Jake Brendel|C}}

{{NFLplayer|60|Daniel Brunskill|G}}

{{NFLplayer|66|Tom Compton|G}}

{{NFLplayer|50|Alex Mack|C}}

{{NFLplayer|68|Colton McKivitz|T}}

{{NFLplayer|76|Jaylon Moore|d=offensive lineman|T|rookie=y}}

{{NFLplayer|75|Laken Tomlinson|G}}

{{NFLplayer|71|Trent Williams|T}}

|Defensive Linemen=

{{NFLplayer|91|Arik Armstead|DE}}

{{NFLplayer|97|Nick Bosa|DE}}

{{NFLplayer|56|Samson Ebukam|DE}}

{{NFLplayer|90|Kevin Givens|DT}}

{{NFLplayer|96|Maurice Hurst Jr.|DT}}

{{NFLplayer|93|D. J. Jones|d=defensive lineman|DT}}

{{NFLplayer|98|Arden Key|DE}}

{{NFLplayer|92|Charles Omenihu|DE}}

{{NFLplayer|95|Kentavius Street|DT}}

{{NFLplayer|94|Jordan Willis|d=American football|DE}}

|Linebackers=

{{NFLplayer|51|Azeez Al-Shaair|OLB}}

{{NFLplayer|45|Demetrius Flannigan-Fowles|OLB}}

{{NFLplayer|57|Dre Greenlaw|OLB}}

{{NFLplayer|36|Marcell Harris|MLB}}

{{NFLplayer|54|Fred Warner|d=American football|MLB}}

|Defensive Backs=

{{NFLplayer|29|Talanoa Hufanga|SS|rookie=y}}

{{NFLplayer|27|Dontae Johnson|CB}}

{{NFLplayer|38|Deommodore Lenoir|CB|rookie=y}}

{{NFLplayer| 4|Emmanuel Moseley|CB}}

{{NFLplayer|26|Josh Norman|CB}}

{{NFLplayer| 3|Jaquiski Tartt|SS}}

{{NFLplayer|20|Ambry Thomas|CB|rookie=y}}

{{NFLplayer| 1|Jimmie Ward|FS}}

{{NFLplayer|24|K'Waun Williams|CB}}

|Special Teams=

{{NFLplayer| 9|Robbie Gould|K}}

{{NFLplayer|46|Taybor Pepper|LS}}

{{NFLplayer|18|Mitch Wishnowsky|P}}

|Reserve Lists=

{{NFLplayer|55|Dee Ford|DE|IR}}

{{NFLplayer|13|Richie James|WR|IR}}

{{NFLplayer|--|KeeSean Johnson|WR|Futures}}

{{NFLplayer|99|Javon Kinlaw|DT|IR}}

{{NFLplayer|69|Mike McGlinchey|d=offensive lineman|T|IR}}

{{NFLplayer|33|Tarvarius Moore|SS|PUP}}

{{NFLplayer|--|Justin Skule|G|IR}}

{{NFLplayer|31|Raheem Mostert|RB|IR}}

{{NFLplayer| 2|Jason Verrett|CB|IR}}

{{NFLplayer|32|Tavon Wilson|SS|IR}}

|Practice Squad=

{{NFLplayer|58|Alex Barrett|DE}}

{{NFLplayer|67|Darrion Daniels|DT|PS/I}}

{{NFLplayer|43|Darqueze Dennard|CB}}

{{NFLplayer|77|Alfredo Gutiérrez|d=American football|C|int=y|rookie=y}}

{{NFLplayer|61|Jon Halapio|C}}

{{NFLplayer|35|Brian Hill|d=American football|RB}}

{{NFLplayer|47|Lavert Hill|CB}}

{{NFLplayer|40|Josh Hokit|FB}}

{{NFLplayer|84|Tanner Hudson|TE}}

{{NFLplayer|86|Austin Mack|WR}}

{{NFLplayer|88|Jordan Matthews|TE}}

{{NFLplayer|62|Wyatt Miller|T}}

{{NFLplayer|53|Mark Nzeocha|MLB}}

{{NFLplayer|59|Curtis Robinson|OLB|rookie=y}}

{{NFLplayer|78|Chris Slayton|DT}}

{{NFLplayer| 7|Nate Sudfeld|QB}}

{{NFLplayer|83|Connor Wedington|WR|rookie=y}}

{{NFLplayer|30|Jarrod Wilson|FS}}

}}

The 49ers' preseason schedule was announced on May 12.

The 49ers' 2021 schedule was announced on May 12.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week One: San Francisco 49ers at Detroit Lions – Game summary

|date=September 12

|time=1:00 p.m. EDT/10:00 a.m. PDT

|road=49ers

|R1=7|R2=24|R3=7|R4=3

|home=Lions

|H1=0|H2=10|H3=7|H4=16

|stadium=Ford Field, Detroit, Michigan

|attendance=59,374

|weather=None (indoor stadium)

|referee=Brad Rogers

|TV=Fox

|TVAnnouncers=Kevin Kugler, Mark Sanchez and Laura Okmin

|reference=[https://www.nfl.com/games/49ers-at-lions-2021-reg-1 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58508/DET_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Trent Sherfield 5-yard pass from Trey Lance (Robbie Gould kick), 5:41. 49ers 7–0. Drive: 7 plays, 59 yards, 3:55.

Second quarter

• DET – T. J. Hockenson 6-yard pass from Jared Goff (Austin Seibert kick), 13:29. Tied 7–7. Drive: 13 plays, 82 yards, 7:12.
• SF – Elijah Mitchell 38-yard run (Robbie Gould kick), 11:12. 49ers 14–7. Drive: 4 plays, 78 yards, 2:17.
• DET – Austin Seibert 49-yard field goal, 6:13. 49ers 14–10. Drive: 9 plays, 44 yards, 4:59.
• SF – JaMycal Hasty 3-yard run (Robbie Gould kick), 2:25. 49ers 21–10. Drive: 7 plays, 75 yards, 3:48.
• SF – Dre Greenlaw 39-yard interception return (Robbie Gould kick), 1:10. 49ers 28–10.
• SF – Robbie Gould 40-yard field goal, 0:03. 49ers 31–10. Drive: 7 plays, 50 yards, 0:41.

Third quarter

• SF – Deebo Samuel 79-yard pass from Jimmy Garoppolo (Robbie Gould kick), 7:54. 49ers 38–10. Drive: 5 plays, 91 yards, 2:22.
• DET – D'Andre Swift 43-yard pass from Jared Goff (Austin Seibert kick), 4:23. 49ers 38–17. Drive: 7 plays, 75 yards, 3:31.

Fourth quarter

• SF – Robbie Gould 52-yard field goal, 9:53. 49ers 41–17. Drive: 7 plays, 19 yards, 3:45.
• DET – Jamaal Williams 1-yard run (Jared Goff–T. J. Hockenson pass), 1:53. 49ers 41–25. Drive: 12 plays, 86 yards, 3:52.
• DET – Quintez Cephus 2-yard pass from Jared Goff (Jared Goff–Quintez Cephus pass), 1:07. 49ers 41–33. Drive: 6 plays, 59 yards, 0:46.

|stats=

Top passers

• SF – Jimmy Garoppolo – 17/25, 314 yards, TD
• DET – Jared Goff – 38/57, 338 yards, 3 TD, INT

Top rushers

• SF – Elijah Mitchell – 19 rushes, 104 yards, TD
• DET – Jamaal Williams – 9 rushes, 54 yards, TD

Top receivers

• SF – Deebo Samuel – 9 receptions, 189 yards, TD
• DET – T. J. Hockenson – 8 receptions, 97 yards, TD

}}

49ers hold on to go up 1-0 to kick off the 75th season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Two: San Francisco 49ers at Philadelphia Eagles – Game summary

|date=September 19

|time=1:00 p.m. EDT/10:00 a.m. PDT

|road=49ers

|R1=0|R2=7|R3=0|R4=10

|home=Eagles

|H1=3|H2=0|H3=0|H4=8

|stadium=Lincoln Financial Field, Philadelphia, Pennsylvania

|attendance=69,796

|weather=Clear, {{convert|75|F|C}}

|referee=Brad Allen

|TV=Fox

|TVAnnouncers=Adam Amin, Mark Schlereth and Shannon Spake

|reference=[https://www.nfl.com/games/49ers-at-eagles-2021-reg-2 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58527/PHI_Gamebook.pdf Game Book]

|scoring=

First quarter

• PHI – Jake Elliott 45-yard field goal, 4:45. Eagles 3–0. Drive: 11 plays, 53 yards, 4:43.

Second quarter

• SF – Jauan Jennings 11-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:12. 49ers 7–3. Drive: 12 plays, 97 yards, 4:08.

Third quarter

• No scoring plays.

Fourth quarter

• SF – Jimmy Garoppolo 1-yard run (Robbie Gould kick), 10:52. 49ers 14–3. Drive: 16 plays, 92 yards, 8:59.
• SF – Robbie Gould 46-yard field goal, 5:07. 49ers 17–3. Drive: 9 plays, 53 yards, 3:10.
• PHI – Jalen Hurts 1-yard run (Kenneth Gainwell run), 4:02. 49ers 17–11. Drive: 5 plays, 75 yards, 1:05.

|stats=

Top passers

• SF – Jimmy Garoppolo – 22/30, 189 yards, TD
• PHI – Jalen Hurts – 12/23, 190 yards

Top rushers

• SF – Elijah Mitchell – 17 rushes, 42 yards
• PHI – Jalen Hurts – 10 rushes, 82 yards, TD

Top receivers

• SF – Deebo Samuel – 6 receptions, 93 yards
• PHI – Quez Watkins – 2 receptions, 117 yards

}}

With the Victory, The 49ers are 2-0 on the season

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Three: Green Bay Packers at San Francisco 49ers – Game summary

|date=September 26

|time=5:20 p.m. PDT

|road=Packers

|R1=10|R2=7|R3=0|R4=13

|home=49ers

|H1=0|H2=7|H3=7|H4=14

|stadium=Levi's Stadium, Santa Clara, California

|attendance=69,853

|weather=Scattered clouds, {{convert|69|F|C}}

|referee=Jerome Boger

|TV=NBC

|TVAnnouncers=Al Michaels, Cris Collinsworth, Michele Tafoya and Terry McAulay

|reference=[https://www.nfl.com/games/packers-at-49ers-2021-reg-3 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58549/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• GB – Mason Crosby 54-yard field goal, 10:06. Packers 3–0. Drive: 8 plays, 39 yards, 4:54.
• GB – Davante Adams 1-yard pass from Aaron Rodgers (Mason Crosby kick), 3:19. Packers 10–0. Drive: 7 plays, 80 yards, 4:06.

Second quarter

• GB – Aaron Jones 3-yard run (Mason Crosby kick), 1:02. Packers 17–0. Drive: 9 plays, 87 yards, 3:46.
• SF – Trey Lance 1-yard run (Robbie Gould kick), 0:00. Packers 17–7. Drive: 8 plays, 32 yards, 1:02.

Third quarter

• SF – Brandon Aiyuk 8-yard pass from Jimmy Garoppolo (Robbie Gould kick), 7:41. Packers 17–14. Drive: 13 plays, 83 yards, 7:19.

Fourth quarter

• GB – Marquez Valdes-Scantling 12-yard pass from Aaron Rodgers (Mason Crosby kick), 13:27. Packers 24–14. Drive: 10 plays, 86 yards, 5:57.
• SF – Trey Sermon 1-yard run (Robbie Gould kick), 7:48. Packers 24–21. Drive: 9 plays, 81 yards, 5:39.
• GB – Mason Crosby 38-yard field goal, 2:39. Packers 27–21. Drive: 5 plays, 18 yards, 2:19.
• SF – Kyle Juszczyk 12-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:37. 49ers 28–27. Drive: 8 plays, 75 yards, 2:02.
• GB – Mason Crosby 51-yard field goal, 0:00. Packers 30–28. Drive: 6 plays, 42 yards, 0:37.

|stats=

Top passers

• GB – Aaron Rodgers – 23/33, 261 yards, 2 TD
• SF – Jimmy Garoppolo – 25/40, 257 yards, 2 TD, INT

Top rushers

• GB – Aaron Jones – 19 rushes, 82 yards, TD
• SF – Trey Sermon – 10 rushes, 31 yards, TD

Top receivers

• GB – Davante Adams – 12 receptions, 132 yards, TD
• SF – George Kittle – 7 receptions, 92 yards

}}

The Packers narrowly escape the 49ers and deliver San Francisco its first loss on the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Four: Seattle Seahawks at San Francisco 49ers – Game summary

|date=October 3

|time=1:05 p.m. PDT

|road=Seahawks

|R1=0|R2=7|R3=14|R4=7

|home=49ers

|H1=7|H2=0|H3=6|H4=8

|stadium=Levi's Stadium, Santa Clara, California

|attendance=68,912

|weather=Hazy skies, {{convert|88|F|C}}

|referee=Carl Cheffers

|TV=Fox

|TVAnnouncers=Adam Amin, Mark Schlereth and Shannon Spake

|reference=[https://www.nfl.com/games/seahawks-at-49ers-2021-reg-4 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58562/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Ross Dwelley 21-yard pass from Jimmy Garoppolo (Mitch Wishnowsky kick), 9:35. 49ers 7–0. Drive: 8 plays, 71 yards, 4:13.

Second quarter

• SEA – DK Metcalf 12-yard pass from Russell Wilson (Jason Myers kick), 1:54. Tied 7–7. Drive: 6 plays, 80 yards, 2:55.

Third quarter

• SEA – Russell Wilson 16-yard run (Jason Myers kick), 5:22. Seahawks 14–7. Drive: 7 plays, 66 yards, 3:31.
• SEA – Freddie Swain 13-yard pass from Russell Wilson (Jason Myers kick), 4:26. Seahawks 21–7. Drive: 2 plays, 14 yards, 0:50.
• SF – Deebo Samuel 76-yard pass from Trey Lance (kick failed), 2:10. Seahawks 21–13. Drive: 4 plays, 89 yards, 2:16.

Fourth quarter

• SEA – Alex Collins 14-yard run (Jason Myers kick), 12:07. Seahawks 28–13. Drive: 10 plays, 81 yards, 5:03.
• SF – Deebo Samuel 8-yard pass from Trey Lance (Trey Lance run), 1:20. Seahawks 28–21. Drive: 13 plays, 80 yards, 3:10.

|stats=

Top passers

• SEA – Russell Wilson – 16/23, 149 yards, 2 TD
• SF – Jimmy Garoppolo – 14/23, 165 yards, TD, INT

Top rushers

• SEA – Alex Collins – 10 rushes, 44 yards, TD
• SF – Trey Sermon – 19 rushes, 89 yards

Top receivers

• SEA – DK Metcalf – 4 receptions, 65 yards, TD
• SF – Deebo Samuel – 8 receptions, 156 yards, 2 TD

}}

Despite a late rally, the 49ers could not hold off the Seahawks at Levi's and drop to 2–2 on the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Five: San Francisco 49ers at Arizona Cardinals – Game summary

|date=October 10

|time=1:25 p.m. MST & PDT

|road=49ers

|R1=0|R2=0|R3=7|R4=3

|home=Cardinals

|H1=7|H2=3|H3=0|H4=7

|stadium=State Farm Stadium, Glendale, Arizona

|attendance=62,716

|weather=None (retractable roof closed)

|referee=Clay Martin

|TV=Fox

|TVAnnouncers=Kevin Kugler, Mark Sanchez and Laura Okmin

|reference=[https://www.nfl.com/games/49ers-at-cardinals-2021-reg-5 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58579/ARI_Gamebook.pdf Game Book]

|scoring=

First quarter

• ARI – James Conner 1-yard run (Matt Prater kick), 9:02. Cardinals 7–0. Drive: 8 plays, 66 yards, 3:44.

Second quarter

• ARI – Matt Prater 21-yard field goal, 5:27. Cardinals 10–0. Drive: 14 plays, 96 yards, 5:59.

Third quarter

• SF – Deebo Samuel 13-yard run, (Joey Slye kick) 1:42. Cardinals 10–7. Drive: 6 plays, 59 yards, 3:28.

Fourth quarter

• ARI – DeAndre Hopkins 9-yard pass from Kyler Murray, (Matt Prater kick) 5:13. Cardinals 17–7. Drive: 5 plays, 52 yards, 2:36.
• SF – Joey Slye 47-yard field goal, 4:12. Cardinals 17–10. Drive: 6 plays, 46 yards, 1:01.

|stats=

Top passers

• SF – Trey Lance – 15/29, 192 yards, INT
• ARI – Kyler Murray – 22/31, 239 yards, TD

Top rushers

• SF – Trey Lance – 16 rushes, 89 yards
• ARI – Rondale Moore – 3 rushes, 38 yards

Top receivers

• SF – Deebo Samuel – 3 receptions, 58 yards
• ARI – DeAndre Hopkins – 6 receptions, 87 yards, TD

}}

In Trey Lance's first NFL start the 49ers lose a closer than expected game and fall to 2–3 on the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Seven: Indianapolis Colts at San Francisco 49ers – Game summary

|date=October 24

|time=5:20 p.m. PDT

|road=Colts

|R1=7|R2=6|R3=7|R4=10

|home=49ers

|H1=12|H2=0|H3=0|H4=6

|stadium=Levi's Stadium, Santa Clara, California

|attendance=56,576

|weather=Cloudy, rainy, {{convert|64|F|C}}

|referee=Craig Wrolstad

|TV=NBC

|TVAnnouncers=Al Michaels, Cris Collinsworth, Michele Tafoya and Terry McAulay

|reference=[https://www.nfl.com/games/colts-at-49ers-2021-reg-7 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58608/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Elijah Mitchell 14-yard run (kick failed, wide right), 10:12. 49ers 6–0. Drive: 8 plays, 78 yards, 4:48.
• SF – Joey Slye 34-yard field goal, 8:08. 49ers 9–0. Drive: 5 plays, 12 yards, 1:44.
• IND – Mo Alie-Cox 11-yard pass from Carson Wentz (Michael Badgley kick), 5:15. 49ers 9–7. Drive: 6 plays, 75 yards, 2:53.
• SF – Joey Slye 56-yard field goal, 2:27. 49ers 12–7. Drive: 6 plays, 39 yards, 2:48.

Second quarter

• IND – Carson Wentz 1-yard run (pass failed) 1:00. Colts 13–12. Drive: 5 plays, 28 yards, 2:02.

Third quarter

• IND – Jonathan Taylor 5-yard run (Michael Badgley kick), 3:45. Colts 20–12. Drive: 1 play, 33 yards, 0:53.

Fourth quarter

• SF – Deebo Samuel 14-yard pass from Jimmy Garoppolo (pass failed), 13:07. Colts 20–18. Drive: 3 plays, 70 yards, 1:11.
• IND – Michael Badgley 42-yard field goal, 7:00. Colts 23–18. Drive: 10 plays, 49 yards, 6:07.
• IND – Michael Pittman Jr. 28-yard pass from Carson Wentz (Michael Badgley kick), 2:49. Colts 30–18. Drive: 6 plays, 39 yards, 2:31.

|stats=

Top passers

• IND – Carson Wentz – 17/26, 150 yards, 2 TD
• SF – Jimmy Garoppolo – 16/27, 181 yards, TD, 2 INT

Top rushers

• IND – Jonathan Taylor – 18 rushes, 107 yards, TD
• SF – Elijah Mitchell – 18 rushes, 107 yards, TD

Top receivers

• IND – Michael Pittman Jr. – 4 receptions, 105 yards, TD
• SF – Deebo Samuel – 7 receptions, 100 yards, TD

}}

With their fourth loss in a row, the 49ers go down to 2–4.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Eight: San Francisco 49ers at Chicago Bears – Game summary

|date=October 31

|time=12:00 p.m. CDT/10:00 a.m. PDT

|road=49ers

|R1=3|R2=6|R3=6|R4=18

|home=Bears

|H1=3|H2=10|H3=3|H4=6

|stadium=Soldier Field, Chicago, Illinois

|attendance=60,877

|weather=Partly sunny, {{convert|52|F|C}}

|referee=Land Clark

|TV=Fox

|TVAnnouncers=Adam Amin, Greg Olsen and Pam Oliver

|reference=[https://www.nfl.com/games/49ers-at-bears-2021-reg-8 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58613/CHI_Gamebook.pdf Game Book]

|scoring=

First quarter

• CHI – Cairo Santos 39-yard field goal, 4:38. Bears 3–0. Drive: 9 plays, 41 yards, 5:10.
• SF – Joey Slye 48-yard field goal, 2:51. Tied 3–3. Drive: 6 plays, 45 yards, 1:47.

Second quarter

• CHI – Jesse James 8-yard pass from Justin Fields (Cairo Santos kick), 12:03. Bears 10–3. Drive: 11 plays, 74 yards, 5:48.
• SF – Joey Slye 52-yard field goal, 9:33. Bears 10–6. Drive: 7 plays, 41 yards, 2:30.
• CHI – Cairo Santos 40-yard field goal, 1:16. Bears 13–6. Drive: 16 plays, 57 yards, 8:17.
• SF – Joey Slye 22-yard field goal, 0:00. Bears 13–9. Drive: 7 plays, 71 yards, 1:16.

Third quarter

• CHI – Cairo Santos 25-yard field goal, 8:33. Bears 16–9. Drive: 13 plays, 62 yards, 6:27.
• SF – Jimmy Garoppolo 2-yard run (kick failed, wide right), 5:56. Bears 16–15. Drive: 7 plays, 75 yards, 2:37.

Fourth quarter

• SF – Elijah Mitchell 5-yard run (Jimmy Garoppolo–Brandon Aiyuk pass), 14:11. 49ers 23–16. Drive: 6 plays, 52 yards, 2:49.
• CHI – Justin Fields 22-yard run (kick failed, wide right), 9:32. 49ers 23–22. Drive: 9 plays, 68 yards, 4:39.
• SF – Jimmy Garoppolo 5-yard run (Joey Slye kick), 6:34. 49ers 30–22. Drive: 5 plays, 75 yards, 2:58.
• SF – Joey Slye 32-yard field goal, 1:56. 49ers 33–22. Drive: 7 plays, 49 yards, 2:28.

|stats=

Top passers

• SF – Jimmy Garoppolo – 17/28, 322 yards
• CHI – Justin Fields – 19/27, 175 yards, TD, INT

Top rushers

• SF – Elijah Mitchell – 18 rushes, 137 yards, TD
• CHI – Justin Fields – 10 rushes, 103 yards, TD

Top receivers

• SF – Deebo Samuel – 6 receptions, 171 yards
• CHI – Darnell Mooney – 6 receptions, 64 yards

}}

Despite struggling in the first half of the game falling behind 16–9, the 49ers would rally, outscoring the Bears 24–6 to pick up the win and improving them to 3–4.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Nine: Arizona Cardinals at San Francisco 49ers – Game summary

|date=November 7

|time=1:25 p.m. PST

|road=Cardinals

|R1=14|R2=3|R3=14|R4=0

|home=49ers

|H1=0|H2=7|H3=7|H4=3

|stadium=Levi's Stadium, Santa Clara, California

|attendance=59,012

|weather=Scattered clouds, {{convert|62|F|C}}

|referee=Brad Allen

|TV=Fox

|TVAnnouncers=Kevin Kugler, Mark Sanchez and Laura Okmin

|reference=[https://www.nfl.com/games/cardinals-at-49ers-2021-reg-9 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58636/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• ARI – James Conner 13-yard run (Matt Prater kick), 6:08. Cardinals 7–0. Drive: 9 plays, 57 yards, 4:21.
• ARI – James Conner 1-yard run (Matt Prater kick), 0:39. Cardinals 14–0. Drive: 8 plays, 80 yards, 3:59.

Second quarter

• ARI – Matt Prater 26-yard field goal, 4:02. Cardinals 17–0. Drive: 14 plays, 85 yards, 8:23.
• SF – George Kittle 6-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:16. Cardinals 17–7. Drive: 9 plays, 75 yards, 3:46.

Third quarter

• ARI – James Conner 45-yard pass from Colt McCoy (Matt Prater kick), 13:33. Cardinals 24–7. Drive: 3 plays, 72 yards, 1:27.
• ARI – Eno Benjamin 21-yard run (Matt Prater kick), 8:05. Cardinals 31–7. Drive: 7 plays, 71 yards, 3:47.
• SF – Brandon Aiyuk 11-yard pass from Jimmy Garoppolo (Robbie Gould kick), 4:56. Cardinals 31–14. Drive: 6 plays, 75 yards, 3:09.

Fourth quarter

• SF – Robbie Gould 26-yard field goal, 8:23. Cardinals 31–17. Drive: 7 plays, 28 yards, 2:34.

|stats=

Top passers

• ARI – Colt McCoy – 22/26, 249 yards, TD
• SF – Jimmy Garoppolo – 28/40, 322 yards, 2 TD, INT

Top rushers

• ARI – James Conner – 21 rushes, 96 yards, 2 TD
• SF – Elijah Mitchell – 8 rushes, 36 yards

Top receivers

• ARI – Christian Kirk – 6 receptions, 91 yards
• SF – George Kittle – 6 receptions, 101 yards, TD

}}

Despite the Cardinals having an injury–depleted roster, the 49ers suffer an embarrassing loss to former 49ers QB Colt McCoy and fall to 3–5 on the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Ten: Los Angeles Rams at San Francisco 49ers – Game summary

|date={{dow tooltip|November 15, 2021}}

|time=5:15 p.m. PST

|road=Rams

|R1=0|R2=7|R3=0|R4=3

|home=49ers

|H1=14|H2=7|H3=3|H4=7

|stadium=Levi's Stadium, Santa Clara, California

|attendance=64,256

|weather=Overcast, {{convert|62|F|C}}

|referee=Shawn Smith

|TV=ESPN

|TVAnnouncers=Steve Levy, Brian Griese, Louis Riddick, Lisa Salters and John Parry

|reference=[https://www.nfl.com/games/rams-at-49ers-2021-reg-10 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58652/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – George Kittle 8-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:54. 49ers 7–0. Drive: 18 plays, 93 yards, 11:03.
• SF – Jimmie Ward 27-yard interception return (Robbie Gould kick), 0:49. 49ers 14–0.

Second quarter

• LAR – Tyler Higbee 10-yard pass from Matthew Stafford (Matt Gay kick), 13:16. 49ers 14–7. Drive: 7 plays, 75 yards, 2:33.
• SF – Deebo Samuel 8-yard run (Robbie Gould kick), 5:24. 49ers 21–7. Drive: 11 plays, 91 yards, 7:52.

Third quarter

• SF – Robbie Gould 50-yard field goal, 4:38. 49ers 24–7. Drive: 10 plays, 31 yards, 6:14.

Fourth quarter

• SF – Deebo Samuel 40-yard pass from Jimmy Garoppolo (Robbie Gould kick), 11:07. 49ers 31–7. Drive: 6 plays, 56 yards, 3:53.
• LAR – Matt Gay 37-yard field goal, 3:48. 49ers 31–10. Drive: 7 plays, 33 yards, 1:11.

|stats=

Top passers

• LAR – Matthew Stafford – 26/41, 243 yards, TD, 2 INT
• SF – Jimmy Garoppolo – 15/19, 182 yards, 2 TD

Top rushers

• LAR – Darrell Henderson Jr. – 5 rushes, 31 yards
• SF – Elijah Mitchell – 27 rushes, 91 yards

Top receivers

• LAR – Cooper Kupp – 11 receptions, 122 yards
• SF – Deebo Samuel – 5 receptions, 97 yards, TD

}}

The 49ers bounced back against their interstate rivals, defeating them for the 5th consecutive time and bringing their record up to 4–5 for the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Eleven: San Francisco 49ers at Jacksonville Jaguars – Game summary

|date=November 21

|time=1:00 p.m. EST/10:00 a.m. PST

|road=49ers

|R1=3|R2=17|R3=7|R4=3

|home=Jaguars

|H1=0|H2=3|H3=0|H4=7

|stadium=TIAA Bank Field, Jacksonville, Florida

|attendance=60,268

|weather=Sunny, {{convert|67|F|C}}

|referee=Ronald Torbert

|TV=Fox

|TVAnnouncers=Chris Myers, Daryl Johnston and Jen Hale

|reference=[https://www.nfl.com/games/49ers-at-jaguars-2021-reg-11 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58658/JAX_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Robbie Gould 20-yard field goal, 1:55. 49ers 3–0. Drive: 20 plays, 87 yards, 13:05.

Second quarter

• SF – Deebo Samuel 25-yard run (Robbie Gould kick), 11:24. 49ers 10–0. Drive: 7 plays, 80 yards, 3:56.
• SF – Brandon Aiyuk 6-yard pass from Jimmy Garoppolo (Robbie Gould kick), 8:25. 49ers 17–0. Drive: 7 plays, 35 yards, 2:51.
• JAX – Matthew Wright 30-yard field goal, 1:53. 49ers 17–3. Drive: 12 plays, 67 yards, 6:32.
• SF – Robbie Gould 48-yard field goal, 0:00. 49ers 20–3. Drive: 7 plays, 45 yards, 1:53.

Third quarter

• SF – George Kittle 1-yard pass from Jimmy Garoppolo (Robbie Gould kick), 8:49. 49ers 27–3. Drive: 11 plays, 77 yards, 5:45.

Fourth quarter

• SF – Robbie Gould 45-yard field goal, 5:33. 49ers 30–3. Drive: 5 plays, 17 yards, 3:00.
• JAX – James Robinson 1-yard run (Matthew Wright kick), 3:04. 49ers 30–10. Drive: 8 plays, 75 yards, 2:29.

|stats=

Top passers

• SF – Jimmy Garoppolo – 16/22, 176 yards, 2 TD
• JAX – Trevor Lawrence – 16/25, 158 yards

Top rushers

• SF – Deebo Samuel – 8 rushes, 79 yards, TD
• JAX – James Robinson – 12 rushes, 29 yards, TD

Top receivers

• SF – Brandon Aiyuk – 7 receptions, 85 yards, TD
• JAX – Laviska Shenault – 5 receptions, 50 yards

}}

49ers got back to .500 by beating the Jags.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Twelve: Minnesota Vikings at San Francisco 49ers – Game summary

|date=November 28

|time=1:25 p.m. PST

|road=Vikings

|R1=7|R2=7|R3=12|R4=0

|home=49ers

|H1=7|H2=7|H3=20|H4=0

|stadium=Levi's Stadium, Santa Clara, California

|attendance=71,493

|weather=Clear, {{convert|67|F|C}}

|referee=Brad Rogers

|TV=Fox

|TVAnnouncers=Kenny Albert, Jonathan Vilma, and Sara Walsh

|reference=[https://www.nfl.com/games/vikings-at-49ers-2021-reg-12 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58680/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• MIN – Adam Thielen 2-yard pass from Kirk Cousins (Greg Joseph kick), 8:27. Vikings 7–0. Drive: 8 plays, 49 yards, 3:33.
• SF – Deebo Samuel 20-yard run (Robbie Gould kick), 5:31. Tied 7–7. Drive: 6 plays, 75 yards, 2:56.

Second quarter

• MIN – Adam Thielen 20-yard pass from Kirk Cousins (Greg Joseph kick), 12:42. Vikings 14–7. Drive: 6 plays, 80 yards, 2:50.
• SF – Jauan Jennings 3-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:18. Tied 14–14. Drive: 15 plays, 85 yards, 8:20.

Third quarter

• SF – Deebo Samuel 3-yard run (Robbie Gould kick), 11:31. 49ers 21–14. Drive: 6 plays, 75 yards, 3:29.
• SF – Elijah Mitchell 2-yard run (Robbie Gould kick), 11:09. 49ers 28–14. Drive: 1 play, 2 yards, 0:04.
• MIN – Alexander Mattison 6-yard run (kick failed, wide right), 8:28. 49ers 28–20. Drive: 5 plays, 75 yards, 2:41.
• SF – Robbie Gould 46-yard field goal, 4:58. 49ers 31–20. Drive: 7 plays, 47 yards, 3:30.
• MIN – Kene Nwangwu 99-yard kickoff return (pass failed), 4:46. 49ers 31–26. Drive: 0 plays, 0 yards, 0:12.
• SF – Robbie Gould 22-yard field goal, 0:09. 49ers 34–26. Drive: 4 plays, 5 yards, 1:21.

Fourth quarter

• No scoring plays.

|stats=

Top passers

• MIN – Kirk Cousins – 20/32, 238 yards, 2 TD, INT
• SF – Jimmy Garoppolo – 17/26, 230 yards, TD, INT

Top rushers

• MIN – Dalvin Cook – 10 rushes, 39 yards
• SF – Elijah Mitchell – 27 rushes, 133 yards, TD

Top receivers

• MIN – Justin Jefferson – 4 receptions, 83 yards
• SF – Brandon Aiyuk – 3 receptions, 91 yards

}}

In a crucial game for seeding, the 49ers pulled off a late victory to take the tie breaker and went up to 6–5 on the season.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Thirteen: San Francisco 49ers at Seattle Seahawks – Game summary

|date=December 5

|time=1:25 p.m. PST

|road=49ers

|R1=14|R2=9|R3=0|R4=0

|home=Seahawks

|H1=7|H2=14|H3=9|H4=0

|stadium=Lumen Field, Seattle, Washington

|attendance=68,758

|weather=Sunny, {{convert|41|F|C}}

|referee=Alex Kemp

|TV=CBS

|TVAnnouncers=Kevin Harlan, Tiki Barber and Melanie Collins

|reference=[https://www.nfl.com/games/49ers-at-seahawks-2021-reg-13 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58695/SEA_Gamebook.pdf Game Book]

|scoring=

First quarter

• SEA – Travis Homer 73-yard run (Jason Myers kick), 13:11. Seahawks 7–0. Drive: 4 plays, 77 yards, 1:49.
• SF – George Kittle 24-yard pass from Jimmy Garoppolo (Robbie Gould kick), 10:27. Tied 7–7. Drive: 1 play, 24 yards, 0:07.
• SF – Elijah Mitchell 2-yard run (Robbie Gould kick), 1:32. 49ers 14–7. Drive: 9 plays, 54 yards, 4:10.

Second quarter

• SF – Robbie Gould 50-yard field goal, 9:43. 49ers 17–7. Drive: 9 plays, 31 yards, 5:02.
• SEA – Adrian Peterson 1-yard run (Jason Myers kick), 5:35. 49ers 17–14. Drive: 9 plays, 63 yards, 4:08.
• SF – George Kittle 48-yard pass from Jimmy Garoppolo (kick failed), 1:48. 49ers 23–14. Drive: 7 plays, 75 yards, 3:47.
• SEA – D'Wayne Eskridge 7-yard pass from Russell Wilson (Jason Myers kick), 0:12. 49ers 23–21. Drive: 8 plays, 65 yards, 1:36.

Third quarter

• SEA – Carlos Dunlap sacked Jimmy Garoppolo in end zone for a safety, 10:28. Tied 23–23.
• SEA – Tyler Lockett 12-yard pass from Russell Wilson (Jason Myers kick), 2:28. Seahawks 30–23. Drive: 5 plays, 28 yards, 2:09.

Fourth quarter

• No scoring plays.

|stats=

Top passers

• SF – Jimmy Garoppolo – 20/30, 299 yards, 2 TD, 2 INT
• SEA – Russell Wilson – 30/37, 231 yards, 2 TD, INT

Top rushers

• SF – Elijah Mitchell – 22 rushes, 66 yards, TD
• SEA – Travis Homer – 3 rushes, 80 yards, TD

Top receivers

• SF – George Kittle – 9 receptions, 181 yards, 2 TD
• SEA – Tyler Lockett – 7 receptions, 68 yards, TD

}}

The Seahawks snapped a 3 game win streak for the 49ers, as their record was evened out at 6–6.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Fourteen: San Francisco 49ers at Cincinnati Bengals – Game summary

|date=December 12

|time=4:25 p.m. EST/1:25 p.m. PST

|road=49ers

|R1=3|R2=14|R3=3|R4=0|R5=6

|home=Bengals

|H1=3|H2=3|H3=0|H4=14|H5=3

|stadium=Paul Brown Stadium, Cincinnati, Ohio

|attendance=50,481

|weather=Sunny, {{convert|45|F|C}}

|referee=Craig Wrolstad

|TV=CBS

|TVAnnouncers=Greg Gumbel, Adam Archuleta and AJ Ross

|reference=[https://www.nfl.com/games/49ers-at-bengals-2021-reg-14 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58699/CIN_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Robbie Gould 33-yard field goal, 6:37. 49ers 3–0. Drive: 4 plays, 8 yards, 2:33.
• CIN – Evan McPherson 37-yard field goal, 0:31. Tied 3–3. Drive: 11 plays, 67 yards, 6:06.

Second quarter

• SF – Deebo Samuel 27-yard run (Robbie Gould kick), 12:05. 49ers 10–3. Drive: 6 plays, 75 yards, 3:26.
• CIN – Evan McPherson 28-yard field goal, 1:42. 49ers 10–6. Drive: 12 plays, 53 yards, 6:06.
• SF – George Kittle 14-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:18. 49ers 17–6. Drive: 4 plays, 31 yards, 0:39.

Third quarter

• SF – Robbie Gould 24-yard field goal, 7:43. 49ers 20–6. Drive: 12 plays, 69 yards, 5:17.

Fourth quarter

• CIN – Ja'Marr Chase 17-yard pass from Joe Burrow (Evan McPherson kick), 9:20. 49ers 20–13. Drive: 6 plays, 66 yards, 2:32.
• CIN – Ja'Marr Chase 32-yard pass from Joe Burrow (Evan McPherson kick), 1:19. Tied 20–20. Drive: 7 plays, 87 yards, 1:21.

Overtime

• CIN – Evan McPherson 41-yard field goal, 6:15. Bengals 23–20. Drive: 7 plays, 52 yards, 3:45.
• SF – Brandon Aiyuk 12-yard pass from Jimmy Garoppolo, 1:53. 49ers 26–23. Drive: 7 plays, 75 yards, 4:22.

|stats=

Top passers

• SF – Jimmy Garoppolo – 27/41, 296 yards, 2 TD
• CIN – Joe Burrow – 25/34, 348 yards, 2 TD

Top rushers

• SF – Jeff Wilson Jr. – 13 rushes, 56 yards
• CIN – Joe Mixon – 18 rushes, 58 yards

Top receivers

• SF – George Kittle – 13 receptions, 151 yards, TD
• CIN – Tee Higgins – 5 receptions, 114 yards

}}

Late heroics and extra time was needed in this regular season classic, Aiyuk and the 49ers leaped to 7–6.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Fifteen: Atlanta Falcons at San Francisco 49ers – Game summary

|date=December 19

|time=1:05 p.m. PST

|road=Falcons

|R1=3|R2=7|R3=3|R4=0

|home=49ers

|H1=3|H2=14|H3=14|H4=0

|stadium=Levi's Stadium, Santa Clara, California

|attendance=71,650

|weather=Clear, {{convert|52|F|C}}

|referee=Clay Martin

|TV=CBS

|TVAnnouncers=Kevin Harlan, Trent Green and Melanie Collins

|reference=[https://www.nfl.com/games/falcons-at-49ers-2021-reg-15 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58723/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• ATL – Younghoe Koo 48-yard field goal, 7:12. Falcons 3–0. Drive: 7 plays, 19 yards, 3:49.
• SF – Robbie Gould 30-yard field goal, 1:21. Tied 3–3. Drive: 11 plays, 79 yards, 5:51.

Second quarter

• SF – Kyle Juszczyk 6-yard run (Robbie Gould kick), 9:14. 49ers 10–3. Drive: 8 plays, 77 yards, 4:16.
• ATL – Russell Gage 20-yard pass from Matt Ryan (Younghoe Koo kick), 4:00. Tied 10–10. Drive: 8 plays, 65 yards, 5:14.
• SF – Deebo Samuel 10-yard run (Robbie Gould kick), 0:33. 49ers 17–10. Drive: 6 plays, 75 yards, 3:27.

Third quarter

• SF – Jeff Wilson Jr. 5-yard run (Robbie Gould kick), 11:11. 49ers 24–10. Drive: 4 plays, 38 yards, 2:10.
• ATL – Younghoe Koo 22-yard field goal, 6:28. 49ers 24–13. Drive: 9 plays, 71 yards, 4:43.
• SF – Jauan Jennings 4-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:17. 49ers 31–13. Drive: 10 plays, 75 yards, 5:11.

Fourth quarter

• No scoring plays.

|stats=

Top passers

• ATL – Matt Ryan – 19/32, 236 yards, TD
• SF – Jimmy Garoppolo – 18/23, 235 yards, TD

Top rushers

• ATL – Mike Davis – 6 rushes, 21 yards
• SF – Jeff Wilson Jr. – 21 rushes, 110 yards, TD

Top receivers

• ATL – Russell Gage – 8 receptions, 91 yards, TD
• SF – George Kittle – 6 receptions, 93 yards

}}

The 49ers inspired 3rd Quarter put them over the Falcons and onto 8–6.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Sixteen: San Francisco 49ers at Tennessee Titans – Game summary

|date={{dow tooltip|December 23, 2021}}

|time=7:20 p.m. CST/5:20 p.m. PST

|road=49ers

|R1=7|R2=3|R3=0|R4=7

|home=Titans

|H1=0|H2=0|H3=10|H4=10

|stadium=Nissan Stadium, Nashville, Tennessee

|attendance=69,361

|weather=Clear, {{convert|54|F|C}}

|referee=Shawn Hochuli

|TV=NFLN

|TVAnnouncers=Kevin Burkhardt, Greg Olsen, Pam Oliver and Kristina Pink

|reference=[https://www.nfl.com/games/49ers-at-titans-2021-reg-16 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58727/TEN_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Jeff Wilson Jr. 1-yard run (Robbie Gould kick) 9:57. 49ers 7–0. Drive: 9 plays, 75 yards, 5:03.

Second quarter

• SF – Robbie Gould 48-yard field goal, 8:31. 49ers 10–0. Drive: 11 plays, 33 yards, 6:19.

Third quarter

• TEN – Randy Bullock 38-yard field goal, 8:45. 49ers 10–3. Drive: 13 plays, 55 yards, 6:15.
• TEN – D'Onta Foreman 3-yard run (Randy Bullock kick), 7:13. Tied 10–10. Drive: 4 plays, 18 yards, 1:23.

Fourth quarter

• TEN – A. J. Brown 18-yard pass from Ryan Tannehill (Randy Bullock kick), 13:02. Titans 17–10. Drive: 7 plays, 59 yards, 3:51.
• SF – Brandon Aiyuk 2-yard pass from Jimmy Garoppolo (Robbie Gould kick), 2:20. Tied 17–17. Drive: 8 plays, 95 yards, 2:58.
• TEN – Randy Bullock 44-yard field goal, 0:04. Titans 20–17. Drive: 8 plays, 49 yards, 2:16.

|stats=

Top passers

• SF – Jimmy Garoppolo – 25/34, 322 yards, TD, 2 INT
• TEN – Ryan Tannehill – 22/29, 209 yards, TD

Top rushers

• SF – Jeff Wilson Jr. – 14 rushes, 45 yards, TD
• TEN – Jeremy McNichols – 7 rushes, 31 yards

Top receivers

• SF – Deebo Samuel – 9 receptions, 159 yards
• TEN – A. J. Brown – 11 receptions, 145 yards, TD

}}

Despite taking a 10–0 lead, the 49ers could not overcome the Titans, who outscored them 20–7 to drop them to 8–7, making their playoff chances looking slim.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Seventeen: Houston Texans at San Francisco 49ers – Game summary

|date=January 2

|time=1:05 p.m. PST

|road=Texans

|R1=0|R2=7|R3=0|R4=0

|home=49ers

|H1=0|H2=3|H3=7|H4=13

|stadium=Levi's Stadium, Santa Clara, California

|attendance=71,612

|weather=Clear, {{convert|64|F|C}}

|referee=Carl Cheffers

|TV=CBS

|TVAnnouncers=Greg Gumbel, Adam Archuleta and AJ Ross

|reference=[https://www.nfl.com/games/texans-at-49ers-2021-reg-17 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58754/SF_Gamebook.pdf Game Book]

|scoring=

First quarter

• No scoring plays.

Second quarter

• HOU – Brandin Cooks 8-yard pass from Davis Mills (Kaʻimi Fairbairn kick) 1:57. Texans 7–0. Drive: 14 plays, 80 yards, 7:15.
• SF – Robbie Gould 37-yard field goal, 0:00. Texans 7–3. Drive: 6 plays, 56 yards, 0:38.

Third quarter

• SF – Elijah Mitchell 8-yard pass from Trey Lance (Robbie Gould kick), 5:53. 49ers 10–7. Drive: 4 plays, 58 yards, 2:21.

Fourth quarter

• SF – Deebo Samuel 45-yard pass from Trey Lance (Robbie Gould kick), 9:56. 49ers 17–7. Drive: 4 plays, 65 yards, 2:08.
• SF – Robbie Gould 27-yard field goal, 3:19. 49ers 20–7. Drive: 10 plays, 71 yards, 3:27.
• SF – Robbie Gould 36-yard field goal, 1:12. 49ers 23–7. Drive: 4 plays, 9 yards, 1:29.

|stats=

Top passers

• HOU – Davis Mills – 21/32, 163 yards, TD, INT
• SF – Trey Lance – 16/23, 249 yards, 2 TD, INT

Top rushers

• HOU – Rex Burkhead – 16 rushes, 47 yards
• SF – Elijah Mitchell – 21 rushes, 119 yards

Top receivers

• HOU – Brandin Cooks – 7 receptions, 66 yards, TD
• SF – Brandon Aiyuk – 4 receptions, 94 yards

}}

In Levi's Season Finale the 49ers got off to a slow start, but then they cruised to their 9th victory in Trey Lance's 2nd NFL start to secure their 2nd winning season in 3 years.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=Week Eighteen: San Francisco 49ers at Los Angeles Rams – Game summary

|date=January 9

|time=1:25 p.m. PST

|road=49ers

|R1=0|R2=3|R3=14|R4=7|R5=3

|home=Rams

|H1=3|H2=14|H3=0|H4=7|H5=0

|stadium=SoFi Stadium, Inglewood, California

|attendance=74,447

|weather=Sunny, {{convert|74|F|C}}

|referee=Jerome Boger

|TV=Fox

|TVAnnouncers=Joe Buck, Troy Aikman, Erin Andrews and Tom Rinaldi

|reference=[https://www.nfl.com/games/49ers-at-rams-2021-reg-18 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58773/LA_Gamebook.pdf Game Book]

|scoring=

First quarter

• LAR – Matt Gay 43-yard field goal, 6:07. Rams 3–0. Drive: 13 plays, 62 yards, 8:53.

Second quarter

• LAR – Tyler Higbee 2-yard pass from Matthew Stafford (Matt Gay kick), 10:26. Rams 10–0. Drive: 12 plays, 61 yards, 6:25.
• LAR – Tyler Higbee 15-yard pass from Matthew Stafford (Matt Gay kick), 6:44. Rams 17–0. Drive: 3 plays, 19 yards, 1:30.
• SF – Robbie Gould 42-yard field goal, 0:00. Rams 17–3. Drive: 6 plays, 61 yards, 0:38.

Third quarter

• SF – Deebo Samuel 16-yard run (Robbie Gould kick), 10:32. Rams 17–10. Drive: 7 plays, 75 yards, 4:28.
• SF – Jauan Jennings 24-yard pass from Deebo Samuel (Robbie Gould kick), 1:46. Tied 17–17. Drive: 11 plays, 74 yards, 7:02.

Fourth quarter

• LAR – Cooper Kupp 4-yard pass from Matthew Stafford (Matt Gay kick), 2:29. Rams 24–17. Drive: 9 plays, 92 yards, 5:13.
• SF – Jauan Jennings 14-yard pass from Jimmy Garoppolo (Robbie Gould kick), 0:26. Tied 24–24. Drive: 5 plays, 88 yards, 1:01.

Overtime

• SF – Robbie Gould 24-yard field goal, 2:45. 49ers 27–24. Drive: 12 plays, 69 yards, 7:15.

|stats=

Top passers

• SF – Jimmy Garoppolo – 23/32, 316 yards, TD, 2 INT
• LAR – Matthew Stafford – 21/32, 238 yards, 3 TD, 2 INT

Top rushers

• SF – Elijah Mitchell – 21 rushes, 85 yards
• LAR – Sony Michel – 21 rushes, 43 yards

Top receivers

• SF – Brandon Aiyuk – 6 receptions, 107 yards
• LAR – Cooper Kupp – 7 receptions, 118 yards, TD

}}

In a game that looked like certain doom for the 49ers, the 49ers roared back to tie the game on a pass from Deebo Samuel to Jauan Jennings to tie the game up. In overtime, Robbie Gould put the 49ers ahead and Ambry Thomas officially punched the 49ers ticket to the playoffs when he picked off Matthew Stafford, the 49ers would finish the regular season at 10–7. This would be the Rams 7th consecutive defeat by the 49ers.

{{2021 NFC West standings|team=SF}}

{{2021 NFC standings|team=SF}}

{{see also|2021–22 NFL playoffs}}

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=NFC Wildcard Playoffs: (6) San Francisco 49ers at (3) Dallas Cowboys – Game summary

|date=January 16, 2022

|time=3:30 p.m. CST/1:30 p.m. PST

|road=49ers

|R1=10|R2=6|R3=7|R4=0

|home=Cowboys

|H1=0|H2=7|H3=0|H4=10

|stadium=AT&T Stadium, Arlington, Texas

|attendance=93,470

|weather=None (retractable roof closed)

|referee=Alex Kemp

|TV=CBS/Nick

|TVAnnouncers={{bulleted list|CBS: Jim Nantz, Tony Romo, and Tracy Wolfson|Nickelodeon: Noah Eagle, Nate Burleson, Gabrielle Nevaeh Green, and Young Dylan}}

|reference=[https://www.nfl.com/games/49ers-at-cowboys-2021-post-1 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58827/DAL_Gamebook.pdf Game Book]

|scoring=

First quarter

• SF – Elijah Mitchell 4-yard run (Robbie Gould kick), 10:54. 49ers 7–0. Drive: 7 plays, 75 yards, 4:06.
• SF – Robbie Gould 53-yard field goal, 4:53. 49ers 10–0. Drive: 9 plays, 23 yards, 4:34.

Second quarter

• SF – Robbie Gould 40-yard field goal, 9:40. 49ers 13–0. Drive: 12 plays, 56 yards, 7:58.
• DAL – Amari Cooper 20-yard pass from Dak Prescott (Greg Zuerlein kick), 5:19. 49ers 13–7. Drive: 9 plays, 67 yards, 4:21.
• SF – Robbie Gould 52-yard field goal, 3:03. 49ers 16–7. Drive: 5 plays, 41 yards, 2:16.

Third quarter

• SF – Deebo Samuel 26-yard run (Robbie Gould kick), 5:50. 49ers 23–7. Drive: 1 play, 26 yards, 0:08.

Fourth quarter

• DAL – Greg Zuerlein 51-yard field goal, 11:53. 49ers 23–10. Drive: 11 plays, 37 yards, 4:41.
• DAL – Dak Prescott 5-yard run (Greg Zuerlein kick), 8:02. 49ers 23–17. Drive: 5 plays, 28 yards, 1:35.

|stats=

Top passers

• SF – Jimmy Garoppolo – 16/25, 172 yards, INT
• DAL – Dak Prescott – 23/43, 254 yards, TD, INT

Top rushers

• SF – Elijah Mitchell – 27 rushes, 96 yards
• DAL – Ezekiel Elliott – 12 rushes, 31 yards

Top receivers

• SF – Brandon Aiyuk – 5 receptions, 66 yards
• DAL – Dalton Schultz – 7 receptions, 89 yards

}}

In the first playoff meeting between these two teams since the 1994 NFC Championship, the 49ers upset the Cowboys 23–17. The 49ers' top-five defense shut down the NFL's highest scoring team (the Cowboys were averaging 31.1 points a game during the regular season) to just 17 points, well below the Cowboys' average. This included five sacks, holding the Cowboys to just 77 yards rushing, and one interception, which led to a 49ers touchdown on the next play. The 49ers dominated most of the game, leading 23–7 entering the fourth quarter, and retaining the lead despite a close comeback from the Cowboys. With the win, the 49ers improved their playoff record against the Cowboys to 3–5 all time and defeated the Cowboys for the first time since 2014.

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=NFC Divisional Playoffs: (6) San Francisco 49ers at (1) Green Bay Packers – Game summary

|date={{dow tooltip|January 22, 2022|df=F j, Y}}

|time=7:15 p.m. CST/5:15 p.m. PST

|road=49ers

|R1=0|R2=0|R3=3|R4=10

|home=Packers

|H1=7|H2=0|H3=0|H4=3

|stadium=Lambeau Field, Green Bay, Wisconsin

|attendance=79,132

|weather=Cloudy, {{convert|14|F|C}}

|referee=Ronald Torbert

|TV=Fox

|TVAnnouncers=Joe Buck, Troy Aikman, Erin Andrews and Tom Rinaldi

|reference=[https://www.nfl.com/games/49ers-at-packers-2021-post-2 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58831/GB_Gamebook.pdf Game Book]

|scoring=

First quarter

• GB – A. J. Dillon 6-yard run (Mason Crosby kick), 9:25. Packers 7–0. Drive: 10 plays, 69 yards, 5:35.

Second quarter

• No scoring plays

Third quarter

• SF – Robbie Gould 29-yard field goal, 8:13. Packers 7–3. Drive: 10 plays, 39 yards, 6:47.

Fourth quarter

• GB – Mason Crosby 33-yard field goal, 11:27. Packers 10–3. Drive: 14 plays, 57 yards, 9:01.
• SF – Talanoa Hufanga 6-yard blocked punt return (Robbie Gould kick), 4:41. Tied 10–10.
• SF – Robbie Gould 45-yard field goal, 0:00. 49ers 13–10. Drive: 9 plays, 44 yards, 3:20.

|stats=

Top passers

• SF – Jimmy Garoppolo – 11/19, 131 yards, INT
• GB – Aaron Rodgers – 20/29, 225 yards

Top rushers

• SF – Elijah Mitchell – 17 rushes, 53 yards
• GB – Aaron Jones – 12 rushes, 41 yards

Top receivers

• SF – George Kittle – 4 receptions, 63 yards
• GB – Aaron Jones – 9 receptions, 129 yards

}}

The 49ers' Cinderella run continued as they traveled to Lambeau Field and pulled off the upset in a 13–10 win over the heavily favored Green Bay Packers.{{citation needed|date=January 2022}} The game, which was affected by snowfall, was a defensive battle. The Packers started the game with a six-yard touchdown run by AJ Dillion to take a 7–0 lead. For the rest of the game, the 49ers defense only surrendered three more points, aided by five sacks, a fumble recovery, and only giving up 263 total yards of offense to the Packers. The 49ers special teams was pivotal, as they blocked a Packers field goal right before halftime, returned a blocked punt for a game-tying touchdown late in the game, and finally, converted a game-winning field goal by kicker Robbie Gould as time expired, the last of which advanced them to their second NFC Championship in the last three seasons and the 17th NFC Championship overall as a franchise. With the Tennessee Titans' loss earlier in the day to the Cincinnati Bengals, coincidentally also on a field goal as time expired, this was the first time since 2010 that both #1 seeded teams were eliminated in the same weekend. With the win, the 49ers improved to 4–0 in the playoffs against Packers quarterback Aaron Rodgers. The 49ers recorded five sacks for the second game in a row, which is the first time that has happened in consecutive playoff games since the 1984 season.{{citation needed|date=January 2022}}

{{Americanfootballbox

|titlestyle={{NFLPrimaryStyle|San Francisco 49ers|year=2021|border=2}};text-align:center;

|state=autocollapse

|title=NFC Championship: (6) San Francisco 49ers at (4) Los Angeles Rams – Game summary

|date=January 30

|time=3:40 p.m. PST

|road=49ers

|R1=0|R2=10|R3=7|R4=0

|home=Rams

|H1=0|H2=7|H3=0|H4=13

|stadium=SoFi Stadium, Inglewood, California

|attendance=73,202

|weather=Sunny, {{convert|62|F|C}}

|referee=Carl Cheffers

|TV=Fox

|TVAnnouncers=Joe Buck, Troy Aikman, Erin Andrews, and Tom Rinaldi

|reference=[https://www.nfl.com/games/49ers-at-rams-2021-post-3 Recap], [https://nflcdns.nfl.com/liveupdate/gamecenter/58835/LA_Gamebook.pdf Game Book]

|scoring=

First quarter

• No scoring plays.

Second quarter

• LAR – Cooper Kupp 16-yard pass from Matthew Stafford (Matt Gay kick), 8:46. Rams 7–0. Drive: 18 plays, 97 yards, 9:33.
• SF – Deebo Samuel 44-yard pass from Jimmy Garoppolo (Robbie Gould kick), 6:10. Tied 7–7. Drive: 4 plays, 75 yards, 2:36.
• SF – Robbie Gould 38-yard field goal, 0:00. 49ers 10–7. Drive: 8 plays, 36 yards, 1:50.

Third quarter

• SF – George Kittle 16-yard pass from Jimmy Garoppolo (Robbie Gould kick), 1:59. 49ers 17–7. Drive: 10 plays, 58 yards, 5:54.

Fourth quarter

• LAR – Cooper Kupp 11-yard pass from Matthew Stafford (Matt Gay kick), 13:30. 49ers 17–14. Drive: 7 plays, 75 yards, 3:29.
• LAR – Matt Gay 40-yard field goal, 6:49. Tied 17–17. Drive: 9 plays, 63 yards, 3:06.
• LAR – Matt Gay 30-yard field goal, 1:46. Rams 20–17. Drive: 10 plays, 49 yards, 4:40.

|stats=

Top passers

• SF – Jimmy Garoppolo – 16/30, 232 yards, 2 TD, INT
• LAR – Matthew Stafford – 31/45, 337 yards, 2 TD, INT

Top rushers

• SF – Deebo Samuel – 7 rushes, 26 yards
• LAR – Cam Akers – 13 rushes, 48 yards

Top receivers

• SF – Deebo Samuel – 4 receptions, 72 yards, TD
• LAR – Cooper Kupp – 11 receptions, 142 yards, 2 TD

}}The 49ers flew to Los Angeles following their win over the Packers to play their division rival Los Angeles Rams in the NFC Championship Game. During the regular season, the 49ers won both games against the Rams, and were looking to complete the season sweep with a win.

San Francisco won the coin toss and elected to defer. The two teams traded punts before Rams quarterback Matthew Stafford drove the offense to the 49ers' 3-yard line before throwing a drive-ending interception to Jimmie Ward. However, the 49ers were unable to muster any points off the pick, and were forced to punt. In the second quarter, the Rams struck first with Stafford completing a touchdown pass to wide receiver Cooper Kupp from 16 yards out to give the Rams a 7–0 lead. However, San Francisco struck right back with Jimmy Garoppolo hitting Deebo Samuel for a 44-yard touchdown to tie the game up at 7. On the Rams' next drive, the Rams drove to the 49ers' 38-yard line, but could only pick up 2 yards over the next three downs, and kicker Matt Gay's 54-yard field goal attempt sailed wide of the goalposts. With just under two minutes remaining in the first half, Garoppolo completed four straight passes to set up kicker Robbie Gould's 38-yard field goal at the end of the half to put San Francisco up 10–7.

In the second half, the two teams once again traded punts. On the 49ers' second drive of the half, short runs by Samuel and short passes by Garoppolo drove San Francisco down to the Rams' 16-yard line, where he hooked up with tight end George Kittle for a touchdown to make the score 17–7. On the Rams' ensuing drive, long passes by Stafford led to Kupp's second touchdown of the game from 11 yards out to cut the deficit to 17–14 with thirteen minutes left. On the 49ers' next two drives, they were forced to punt. The Rams capitalized, with Gay scoring two field goals from 40 and 30 yards out respectively to make the score 20–17 in favor of Los Angeles.

With just under two minutes remaining, the 49ers' offense trotted out on the field in an attempt to make a desperate last-minute drive to tie the game. After an incompletion on first down, Garoppolo completed a pass to Jauan Jennings, but was tackled immediately by the Rams' Travin Howard to bring up a 3rd-and-13 on the 49ers' 22-yard line. On the very next play, Garoppolo was washed out of the pocket by the Rams' defensive line. Defensive tackle Aaron Donald got a hand on Garoppolo, and in desperation, Garoppolo lobbed the ball up, where it was tipped by JaMycal Hasty before falling into the hands of Howard for a game and season-ending interception. Three kneeldowns by Stafford ended the game, and sent the Rams to their second Super Bowl in the last 4 years.

{{Further|National Football League records}}

Statistics correct as of the end of the 2021 NFL season{{cite web |title=2021 NFL Team Total Statistics |url=https://www.espn.com/nfl/stats/team/_/view/ |publisher=ESPN |access-date=10 January 2022}}{{cite web |title=49ers Stats |url=https://www.49ers.com/team/stats/ |publisher=San Francisco 49ers |access-date=10 January 2022}}

{{reflist}}

• {{cite web | url=https://www.pro-football-reference.com/teams/sfo/2021.htm | title=2021 San Francisco 49ers Statistics & Players | website=Pro-Football-Reference.com}}

{{San Francisco 49ers}}

{{San Francisco 49ers seasons}}

{{2021 NFL season by team}}

San Francisco

Category:San Francisco 49ers seasons

Category:2021 in San Francisco

San Francisco 49ers