2021 World Athletics Relays – Women's 4 × 400 metres relay

|World record

|{{flag|Soviet Union}}(Tatyana Ledovskaya, Olga Nazarova, Mariya Pinigina, Olga Bryzgina)

|3:15.17

|{{flagicon|KOR}} Seoul, South Korea

|1 October 1988

|{{flag|United States}}(Phyllis Francis, Natasha Hastings, Sanya Richards-Ross, Francena McCorory)

|3:19.39

|{{flagicon|Bahamas}} Nassau, Bahamas

|3 May 2015

|Texas A&M

(Jania Martin, Syaira Richardson, Charokee Young, Athing Mu)

|3:26.27

|{{flagicon|United States}} Fayetteville, United States

|14 February 2021

|KEY:

| align="center" bgcolor="ccffcc" |Q

|Qualified

| align="center" bgcolor="ddffdd" |q

|Fastest non-qualifiers

| align="center" |WL

|World leading

| align="center" |CR

|Championship record

| align="center" |NR

|National record

| align="center" |SB

|Seasonal best

| align="center" |WC

|2022 World Championships qualification

!Rank

!Heat

!Nation

!Athletes

!Time

!Notes

|1

|2

| align="left" |{{CUB}}

| align="left" |Zurian Hechavarría, Rose Mary Almanza, Lisneidy Veitía, Roxana Gómez

|3:27.90

|Q, SB

|2

|1

| align="left" |{{POL}}

| align="left" |Kornelia Lesiewicz, Małgorzata Hołub-Kowalik, Kinga Gacka, Natalia Kaczmarek

|3:28.11

|Q, SB

|3

|1

| align="left" |{{BEL}}

| align="left" |Cynthia Bolingo, Imke Vervaet, Paulien Couckuyt, Camille Laus

|3:28.27

|Q, SB

|4

|2

| align="left" |{{NED}}

| align="left" |Eva Hovenkamp, Eveline Saalberg, Lisanne de Witte, Femke Bol

|3:28.40

|Q

|5

|3

| align="left" |{{GBR2}}

| align="left" |Ama Pipi, Zoey Clark, Jessie Knight, Jessica Turner

|3:28.83

|Q

|6

|3

| align="left" |{{GER}}

| align="left" |Nadine Gonska, Corinna Schwab, Karolina Pahlitzsch, Ruth Sophia Spelmeyer-Preuß

|3:29.73

|Q, SB

|7

|1

| align="left" |{{ITA}}

| align="left" |Raphaela Lukudo, Eleonora Marchiando, Petra Nardelli, Ayomide Folorunso

|3:30.04

|q, SB, *OG, *WC

|8

|2

| align="left" |{{FRA}}

| align="left" |Amandine Brossier, Sokhna Lacoste, Shana Grebo, Floria Gueï

|3:30.46

|q, SB

|1

| align="left" |{{SUI}}

| align="left" |Silke Lemmens, Rachel Pellaud, Veronica Vancardo, Annina Fahr

|3:34.85

|SB, *WC

|1

| align="left" |{{ESP}}

| align="left" |Sara Gallego, Laura Bueno, Bárbara Camblor, Carmen Sánchez

|3:34.92

|SB, *WC

|3

| align="left" |{{BOT}}

| align="left" |Thomphang Basele, Loungo Matlhaku, Galefele Moroko, Amantle Montsho

|3:34.99

|SB

|3

| align="left" |{{JPN}}

| align="left" |Mayu Kobayashi, Nanako Matsumoto, Ayaka Kawata, Asami Shintaku

|3:35.26

|SB

|2

| align="left" |{{KEN}}

| align="left" |Gladys Musyoki, Veronica Kamumbe Mutua, Sylivia Chematui Chesebe, Mary Moraa

|3:39.34

|SB

|3

| align="left" |{{CHI}}

| align="left" |Stephanie Saavedra, María José Echeverría, Poulette Cardoch, María Fernanda Mackenna

|3:41.28

|SB

!Rank

!Nation

!Athletes

!Time

!Notes

| align="left" |{{CUB}}

| align="left" |Zurian Hechavarría, Rose Mary Almanza, Lisneidy Veitía, Roxana Gómez

|3:28.41

|

| align="left" |{{POL}}

| align="left" |Kornelia Lesiewicz, Małgorzata Hołub-Kowalik, Karolina Łozowska, Natalia Kaczmarek

|3:28.81

|

| align="left" |{{GBR2}}

| align="left" |Laviai Nielsen, Ama Pipi, Emily Diamond, Jessie Knight

|3:29.27

|

| align="left" |{{NED}}

| align="left" |Eva Hovenkamp, Lisanne de Witte, Femke Bol, Lieke Klaver

|3:30.12

|

| align="left" |{{ITA}}

| align="left" |Raphaela Lukudo, Eleonora Marchiando, Petra Nardelli, Ayomide Folorunso

|3:32.69

|

| align="left" |{{GER}}

| align="left" |Nadine Gonska, Corinna Schwab, Karolina Pahlitzsch, Ruth Sophia Spelmeyer-Preuß

|3:33.00

|

| align="left" |{{BEL}}

| align="left" |Paulien Couckuyt, Hanne Maudens, Margo van Puyvelde, Camille Laus

|3:37.66

|

| align="left" |{{FRA}}

| align="left" |Sounkamba Sylla, Brigitte Ntiamoah, Kellya Pauline, Kalyl Amaro

|3:40.58

|