3-Isopropylmalate dehydratase

{{Short description|Class of enzymes}}

{{infobox enzyme

| Name = 3-isopropylmalate dehydratase

| EC_number = 4.2.1.33

| CAS_number = 37290-72-5

| GO_code = 0003861

| image =

| width =

| caption =

}}

3-Isopropylmalate dehydratase ({{EnzExplorer|4.2.1.33}}) is an aconitase homologue,{{cite journal | vauthors = Gross SR, Burns RO, Umbarger HE | title = The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate | journal = Biochemistry | volume = 2 | issue = 5| pages = 1046–52 | year = 1963 | pmid = 14087357 | doi = 10.1021/bi00905a023 }}{{Cite journal | vauthors = Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE | title = The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis | journal = Biochemistry | volume = 3 | issue = 12| pages = 2024–7 |date=December 1964 | pmid = 14269331 | doi = 10.1021/bi00900a043}}{{cite journal | vauthors = Cole FE, Kalyanpur MG, Stevens CM | title = Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine | journal = Biochemistry | volume = 12 | issue = 17 | pages = 3346–50 |date=August 1973 | pmid = 4270046 | doi = 10.1021/bi00741a031}} which catalyses the isomerisation of 2-isopropylmalate to 3-isopropylmalate, via dehydration, in the biosynthesis of leucine.