3-Ketosteroid reductase

{{infobox enzyme

| Name = 3-keto-steroid reductase

| EC_number = 1.1.1.270

| CAS_number = 42616-29-5

| GO_code = 0050576

| image =

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| caption =

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In enzymology, a 3-keto-steroid reductase ({{EC number|1.1.1.270}}) is an enzyme that catalyzes the chemical reaction

:4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP⁺ $\rightleftharpoons$ 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H⁺

Thus, the two substrates of this enzyme are 4alpha-methyl-5alpha-cholest-7-en-3beta-ol and NADP⁺, whereas its 3 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-steroid:NADP⁺ 3-oxidoreductase. This enzyme is also called 3-KSR. This enzyme participates in biosynthesis of steroids.

References

{{cite journal | vauthors = Billheimer JT, Alcorn M, Gaylor JL | date = 1981 | title = Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis | journal = Arch. Biochem. Biophys. | volume = 211 | pages = 430–8 | pmid = 6946726 | doi = 10.1016/0003-9861(81)90474-4 | issue = 1 }}
{{cite journal | vauthors = Swindell AC, Gaylor JL | date = 1968 | title = Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates | journal = J. Biol. Chem. | volume = 243 | pages = 5546–55 | pmid = 4387005 | issue = 21 }}

Category:EC 1.1.1

Category:NADPH-dependent enzymes

Category:Enzymes of unknown structure