4-aminobutyrate—pyruvate transaminase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 4-aminobutyrate---pyruvate transaminase

| EC_number = 2.6.1.96

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

4-aminobutyrate---pyruvate transaminase ({{EC number|2.6.1.96}}, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate transaminase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4-aminobutyrate aminotransferase, 4-aminobutyric acid aminotransferase, aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with systematic name 4-aminobutanoate:pyruvate aminotransferase.{{cite journal | title = Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum |author1 = Van Cauwenberghe, O.R. |author2 =Shelp, B.J. |journal = Phytochemistry |year = 1999 |volume = 52 |issue = 4 |pages = 575–581 |doi=10.1016/s0031-9422(99)00301-5|bibcode = 1999PChem..52..575V }}{{cite journal | vauthors = Palanivelu R, Brass L, Edlund AF, Preuss D | title = Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels | journal = Cell | volume = 114 | issue = 1 | pages = 47–59 | date = July 2003 | pmid = 12859897 | doi = 10.1016/s0092-8674(03)00479-3 | doi-access = free }}{{cite journal | vauthors = Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ | title = Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate | journal = Journal of Experimental Botany | volume = 60 | issue = 6 | pages = 1743–57 | year = 2009 | pmid = 19264755 | pmc = 2671622 | doi = 10.1093/jxb/erp044 }}{{cite journal | vauthors = Clark SM, Di Leo R, Van Cauwenberghe OR, Mullen RT, Shelp BJ | title = Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate | journal = Journal of Experimental Botany | volume = 60 | issue = 11 | pages = 3255–67 | year = 2009 | pmid = 19470656 | pmc = 2718222 | doi = 10.1093/jxb/erp161 }} This enzyme is a type of GABA transaminase, which degrades the neurotransmitter GABA. The enzyme catalyses the following chemical reaction

: (1) 4-aminobutanoate + pyruvate $\backslash rightleftharpoons$ succinate semialdehyde + L-alanine

: (2) 4-aminobutanoate + glyoxylate $\backslash rightleftharpoons$ succinate semialdehyde + glycine

This enzyme requires pyridoxal 5'-phosphate.