4-chlorobenzoate dehalogenase
{{Short description|Class of enzymes}}
{{infobox enzyme
| Name = 4-chlorobenzoate dehalogenase
| EC_number = 3.8.1.6
| CAS_number = 94047-11-7
| GO_code = 0047576
| image =
| width =
| caption =
}}
In enzymology, a 4-chlorobenzoate dehalogenase ({{EC number|3.8.1.6}}) is an enzyme that catalyzes the chemical reaction
:4-chlorobenzoate + H2O 4-hydroxybenzoate + chloride
Thus, the two substrates of this enzyme are 4-chlorobenzoate and H2O, whereas its two products are 4-hydroxybenzoate and chloride.
This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1BVQ}}, {{PDB link|1JXZ}}, and {{PDB link|1NZY}}.
References
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- {{cite journal | vauthors = Müller R, Thiele J, Klages U, Lingens F | title = Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3 | journal = Biochemical and Biophysical Research Communications | volume = 124 | issue = 1 | pages = 178–82 | date = October 1984 | pmid = 6497878 | doi = 10.1016/0006-291X(84)90933-1 }}
- {{cite journal | vauthors = Heppel LA, Porterfield VT | title = Enzymatic dehalogenation of certain brominated and chlorinated compounds | journal = The Journal of Biological Chemistry | volume = 176 | issue = 2 | pages = 763–9 | date = November 1948 | doi = 10.1016/S0021-9258(19)52691-6 | doi-access = free | pmid = 18889931 }}
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{{enzymes}}
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Category:Enzymes of known structure
{{hydrolase-stub}}