5-(carboxyamino)imidazole ribonucleotide synthase
{{Short description|Class of enzymes}}
{{infobox enzyme
| Name = 5-(Carboxyamino)imidazole ribonucleotide synthase
| EC_number = 6.3.4.18
| CAS_number =
| GO_code =
| image =
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In enzymology, a 5-(carboxyamino)imidazole ribonucleotide synthase ({{EnzExplorer|6.3.4.18}}) is an enzyme that catalyzes the chemical reaction
:ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3− ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole ("AIR"), and HCO3−, whereas its 3 products are ADP, phosphate, and 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming).
References
{{reflist|1}}
- {{cite journal | vauthors = Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM | date = 1992 | title = Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway | journal = Biochemistry | volume = 31 | pages = 5022–32 | pmid = 1534690 | doi = 10.1021/bi00136a016 | issue = 21 }}
- {{cite journal | vauthors = Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J | date = 1994 | title = N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli | journal = Biochemistry | volume = 33 | pages = 2269–78 | pmid = 8117684 | doi = 10.1021/bi00174a038 | issue = 8 }}
- {{cite journal | vauthors = Thoden JB, Kappock TJ, Stubbe J, Holden HM | date = 1999 | title = Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily | journal = Biochemistry | volume = 38 | pages = 15480–92 | pmid = 10569930 | doi = 10.1021/bi991618s | issue = 47 }}
{{Ligases CO CS and CN}}
{{Enzymes}}
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Category:Enzymes of unknown structure
{{6.3-enzyme-stub}}