5-HT5B receptor

{{Short description|5-HT receptor protein and the gene which encodes it}}

{{DISPLAYTITLE:5-HT_5B receptor}}

{{#invoke:Infobox_gene|getTemplateData|QID=Q18060028}}

5-HT_5B receptor is a 5-HT receptor protein and the gene which encodes it. The protein is found in rodents, but not in humans, because stop codons in the gene's coding sequence prevent the gene from expressing a functional protein.{{cite journal

| author1= Grailhe, R

| author2= Grabtree, GW

| author3= Hen, R

| title= Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution

| journal= European Journal of Pharmacology

| date= 2001-04-27

| volume= 418

| issue= 3

| pages= 157–67

| doi= 10.1016/S0014-2999(01)00933-5

| pmid= 11343685}} It is believed that the function of the 5-HT_5B receptor has been replaced in humans by some other subclass of 5-HT receptor.{{cite book

| title= The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics

| series= The receptors

| editor= Roth, Bryan L.|editor1-link=Bryan Roth

| year= 2006

| edition= 1st

| publisher= Humana Press

| isbn= 978-1-58829-568-2

| page=25

| url=https://books.google.com/books?id=J6i6YpvCQfIC&q=5-HT5B%20receptor&pg=PA25

| access-date= 2009-11-08

}} 5-HT_5B receptor is a G protein-coupled receptor.{{cite journal

| author= Wisden, William

| author2= Parker, Eric M.

| author3= Mahle, Cathy D.

| author4= Grisel, Darcy A.

| author5= Nowak, Henry P.

| author6= Yocca, Frank D.

| author7= Felder, Christian C.

| author8= Seeburg, Peter H.

| author9= Voigt, Mark M.

| title= Cloning and characterization of the rat 5-HT_5B receptor: Evidence that the 5-HT_5B receptor couples to a G protein in mammalian cell membranes

| journal= FEBS Letters

| date= 1993-10-25

| volume= 333

| issue= 1

| pages= 25–31

| doi= 10.1016/0014-5793(93)80368-5

| pmid= 8224165

| s2cid= 46535116

| doi-access= free

| bibcode= 1993FEBSL.333...25W

}} 5-HT_5B receptor mRNA is expressed primarily in the habenula, hippocampus and inferior olive of rat brains.{{cite journal

| author= Kinsey, AM

| author2= Wainwright, A

| author3= Heavens, R

| author4= Sirinathsinghji, DJ

| author5= Oliver, KR

| title= Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain

| journal= Molecular Brain Research

| date= 2001-03-31

| volume= 88

| issue= 1–2

| pages= 194–8

| doi= 10.1016/S0169-328X(01)00034-1

| pmid= 11295248}} Known agonists for 5-HT_5B include ergotamine and LSD. Known antagonists include methiothepin.