60S ribosomal protein L23

{{Short description|Protein found in humans}}

{{Infobox_gene}}

Large ribosomal subunit protein uL14 is a protein that in humans is encoded by the RPL23 gene.{{cite journal |vauthors=Herault Y, Michel D, Chatelain G, Brun G | title = cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17 | journal = Nucleic Acids Res | volume = 19 | issue = 14 | pages = 4001 |date=Aug 1991 | pmid = 1861993 | pmc = 328500 | doi =10.1093/nar/19.14.4001 }}{{cite web | title = Entrez Gene: RPL23 ribosomal protein L23| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9349}}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL14 family. It is located in the cytoplasm. This gene has been referred to as RPL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

References

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Further reading

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  • {{cite journal |vauthors=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins |journal=Biochem. Cell Biol. |volume=73 |issue= 11–12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=10.1139/o95-101 }}
  • {{cite journal |vauthors=Berchtold MW, Berger MC |title=Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein |journal=Gene |volume=102 |issue= 2 |pages= 283–8 |year= 1991 |pmid= 1874450 |doi=10.1016/0378-1119(91)90091-O }}
  • {{cite journal |vauthors=Yaseen NR, Blobel G |title=Cloning and characterization of human karyopherin β3 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4451–6 |year= 1997 |pmid= 9114010 |doi=10.1073/pnas.94.9.4451 | pmc=20743 |bibcode=1997PNAS...94.4451Y |doi-access=free }}
  • {{cite journal | author=Kenmochi N |title=A map of 75 human ribosomal protein genes |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi= 10.1101/gr.8.5.509 |name-list-style=vanc| author2=Kawaguchi T | author3=Rozen S | display-authors=3 | last4=Davis | first4=E | last5=Goodman | first5=N | last6=Hudson | first6=TJ | last7=Tanaka | first7=T | last8=Page | first8=DC| doi-access=free }}
  • {{cite journal | author=Yoshihama M |title=The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes |journal=Genome Res. |volume=12 |issue= 3 |pages= 379–90 |year= 2002 |pmid= 11875025 |doi= 10.1101/gr.214202 | pmc=155282 |name-list-style=vanc| author2=Uechi T | author3=Asakawa S | display-authors=3 | last4=Kawasaki | first4=K | last5=Kato | first5=S | last6=Higa | first6=S | last7=Maeda | first7=N | last8=Minoshima | first8=S | last9=Tanaka | first9=T }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |name-list-style=vanc| author2=Bauch A | author3=Ruffner H | display-authors=3 | last4=Angrand | first4=Pierre-Olivier | last5=Bergamini | first5=Giovanna | last6=Croughton | first6=Karen | last7=Cruciat | first7=Cristina | last8=Eberhard | first8=Dirk | last9=Gagneur | first9=Julien |s2cid=11683986 }}
  • {{cite journal | author=Shi Y |title=Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis |journal=Exp. Cell Res. |volume=296 |issue= 2 |pages= 337–46 |year= 2004 |pmid= 15149863 |doi= 10.1016/j.yexcr.2004.02.009 |name-list-style=vanc| author2=Zhai H | author3=Wang X | display-authors=3 | last4=Han | first4=Zheyi | last5=Liu | first5=Changjiang | last6=Lan | first6=Mei | last7=Du | first7=Jingping | last8=Guo | first8=Changcun | last9=Zhang | first9=Yumei }}
  • {{cite journal |vauthors=Dai MS, Lu H |title=Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44475–82 |year= 2004 |pmid= 15308643 |doi= 10.1074/jbc.M403722200 |doi-access= free }}
  • {{cite journal | author=Dai MS |title=Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7654–68 |year= 2004 |pmid= 15314173 |doi= 10.1128/MCB.24.17.7654-7668.2004 | pmc=506971 |name-list-style=vanc| author2=Zeng SX | author3=Jin Y | display-authors=3 | last4=Sun | first4=X.-X. | last5=David | first5=L. | last6=Lu | first6=H. }}
  • {{cite journal |vauthors=Jin A, Itahana K, O'Keefe K, Zhang Y |title=Inhibition of HDM2 and Activation of p53 by Ribosomal Protein L23 |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7669–80 |year= 2004 |pmid= 15314174 |doi= 10.1128/MCB.24.17.7669-7680.2004 | pmc=506972 }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |name-list-style=vanc| author2=Moritz A | author3=Lee KA | display-authors=3 | last4=Guo | first4=Ailan | last5=Goss | first5=Valerie L | last6=Spek | first6=Erik J | last7=Zhang | first7=Hui | last8=Zha | first8=Xiang-Ming | last9=Polakiewicz | first9=Roberto D |s2cid=7200157 }}
  • {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

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{{GeneticTranslation}}

{{Ribosome subunits}}

{{gene-17-stub}}

Category:Ribosomal proteins