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• March 25 – Emperor Theodosios III is deposed after a reign of 1 year and 10 months. He is succeeded by the 32-year-old Leo III the Isaurian, a general (strategos) of the Anatolic Theme (modern Turkey). Theodosios and his son enter the clergy, and he probably becomes bishop of Ephesus. Leo brings an end to the Twenty Years' Anarchy in the Byzantine Empire, which marks the beginning of the so-called Isaurian Dynasty.Kaegi (1994), pp. 186, 195Bellinger & Grierson (1992), p. 5Jenkins, Romilly (1966). Byzantium: The Imperial centuries AD 610–1071, p. 56
• Arab–Byzantine War: Muslim general Maslama ibn Abd al-Malik leads his army of 80,000 men from Pergamum to Abydos, where he crosses the Hellespont. To prevent interference by the Bulgars, or by any Byzantine forces in Thrace, he sends part of his army to a covering position near Adrianople; with his main body, Maslama builds siege lines to blockade Constantinople, which is protected by the massive Theodosian Walls.
• August 15 – Siege of Constantinople: Maslama begins a combined land and sea effort to capture Constantinople. The capital controls the Bosporus, access between the Mediterranean and Black Sea, and is defended by a garrison of roughly 25,000 men. Leo III orders the granaries be restocked and siege engines installed. The Arab besiegers are suffering immense losses due to disease, and from attrition of siege warfare.
• September 1 – A Muslim armada, consisting of 1,800 ships commanded by Admiral Suleiman, sails into the Sea of Marmara and drops anchor below the sea walls of Constantinople, to supply their forces ashore. Leo III orders the Byzantine fleet to sally forth from their protected harbors with Greek fire, setting alight the thickly-packed Muslim ships. Many vessels burst into flames, while others collide with each other before sinking.John Cairns, "Road to Manzikert" (2012). Byzantine Warfare in an Age of Crisis and Recovery (Chapter 3), p. 69. {{ISBN|978-1-84884-215-1}}
• Fall – Basil Onomagoulos, Byzantine official, declares himself rival emperor in Sicily after the news arrives that Constantinople has fallen to an Arab siege. Leo III dispatches a chartoularios named Paul, with imperial instructions for the Byzantine army on the island. Basil is arrested and executed; his head is sent to Leo, while the other rebels are mutilated and exiled.

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• March 21 – Battle of Vincy: Charles Martel invades Neustria and defeats the forces of King Chilperic II at Vincy, near Cambrai. He pursues him and his mayor of the palace Ragenfrid to Paris, before turning back to deal with his stepmother Plectrude at Cologne, to turn over half the wealth of his late father Pepin of Herstal. Charles allows both Plectrude and his nephew Theudoald (who at eleven was still a little child) to live (a gesture uncommon for the time), and obliges her to accept his sovereignty.
• Charles Martel consolidates his power, proclaims Clotaire IV king of Austrasia in opposition to Chilperic, and deposes Rigobert, bishop of Reims, replacing him with Milo. He marches against Radbod, king (or duke) of the Frisians, and pushes him back into his territory (later part of the Netherlands). Charles sends the Saxons back over the Weser River, and secures the Rhine border—in the name of Clotaire.
• Paolo Lucio Anafesto dies after a 20-year reign, and is succeeded by Marcello Tegalliano as the second doge of the Republic of Venice.

• Caliph Sulayman ibn Abd al-Malik dies after a 2-year reign, and is succeeded by his cousin Umar II. During his rule he grants tax exemption, and tries to reorganize the Umayyad finances.
• A Muslim expedition under Al-Hurr ibn Abd al-Rahman al-Thaqafi cross the Pyrenees into Aquitanian territory, leading a small raiding party into Septimania (Southern France).

• December 24 – A destructive earthquake, with six months of aftershocks, affects Syria and Mesopotamia.{{cite book | last = Ambraseys | first = N. | authorlink= Nicholas Ambraseys| date = 2009 | title = Earthquakes in the Mediterranean and Middle East: A Multidisciplinary Study of Seismicity up to 1900 | url = https://books.google.com/books?id=FzXSBgAAQBAJ&pg=PA1| edition = First | publisher = Cambridge University Press | isbn = 978-0521872928 | page = 225}}
• Hoshi Ryokan, the world's second-longest surviving hotel, is established in Japan (approximate date).

• Nechtan mac Der-Ilei, king of the Picts, expels the monks from the island of Iona (Scotland).

• Childeric III, king of the Franks (d. 754)
• Elipando, Spanish archbishop and theologian
• Gummarus, Frankish noblemen (d. 774)
• Princess Inoe of Japan (d. 775)
• Rabia Basri, Muslim Sufi mystic and saint (d. 801)

• December 30 – Egwin of Evesham, bishop of Worcester
• Basil Onomagoulos, Byzantine usurper
• Eadwulf I, king of Northumbria
• Isonokami no Maro, Japanese statesman (b. 640)
• Paolo Lucio Anafesto, doge of Venice
• Plectrude, consort of Pepin of Herstal
• Sulayman ibn Abd al-Malik, Muslim caliph (b. 674)
• Theobald, duke of Bavaria (or 719)
• Winnoc, Welsh abbot (or 716)

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