7beta-hydroxysteroid dehydrogenase (NADP+)
{{Short description|Class of enzymes}}
{{DISPLAYTITLE:7beta-hydroxysteroid dehydrogenase (NADP+)}}
{{infobox enzyme
| Name = 7-beta-hydroxysteroid dehydrogenase (NADP+)
| EC_number = 1.1.1.201
| CAS_number = 79393-83-2
| GO_code = 0047022
| image =
| width =
| caption =
| name = 7-beta-hydroxysteroid dehydrogenase
}}
In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) ({{EC number|1.1.1.201}}) is an enzyme that catalyzes the chemical reaction
:a 7beta-hydroxysteroid + NADP+ a 7-oxosteroid + NADPH + H+
Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP+, whereas its 3 products are 7-oxosteroid, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP+ 7-oxidoreductase. Other names in common use include NADP+-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP+).
References
{{reflist|1}}
- {{cite journal | vauthors = Savino S, Ferrandi EE, Forneris F, Rovida S, Riva S, Monti D, Mattevi A | title = Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity | journal = Proteins | volume = 84 | issue = 6 | pages = 859–65 | date = June 2016 | pmid = 27006087 | doi = 10.1002/prot.25036 | s2cid = 36310113 }}
- {{cite journal | vauthors = Hirano S, Masuda N | title = Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens | journal = Applied and Environmental Microbiology | volume = 43 | issue = 5 | pages = 1057–63 | date = May 1982 | doi = 10.1128/AEM.43.5.1057-1063.1982 | pmid = 6954878 | pmc = 244185 | bibcode = 1982ApEnM..43.1057H }}
- {{cite journal | vauthors = MacDonald IA, Roach PD | title = Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum | journal = Biochimica et Biophysica Acta | volume = 665 | issue = 2 | pages = 262–9 | date = August 1981 | pmid = 6945134 | doi = 10.1016/0005-2760(81)90011-4 }}
- {{cite journal | vauthors = MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV | title = Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms | journal = Applied and Environmental Microbiology | volume = 44 | issue = 5 | pages = 1187–95 | date = November 1982 | doi = 10.1128/AEM.44.5.1187-1195.1982 | pmid = 6758698 | pmc = 242167 | bibcode = 1982ApEnM..44.1187M }}
{{Alcohol oxidoreductases}}
{{Enzymes}}
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Category:NADPH-dependent enzymes
Category:Enzymes of unknown structure
{{1.1.1-enzyme-stub}}