A. Thomas Look

Look received a BSE in Chemical Engineering from University of Michigan, Ann Arbor, in 1971, followed by a degree in medicine (MD) from the same university in 1975.{{cite web|url=https://www.dana-farber.org/find-a-doctor/a-thomas-look/|title=A. Thomas Look, MD|publisher=Dana-Farber Cancer Institute|accessdate=September 6, 2019}} He undertook most of his training in pediatric oncology at St. Jude Children's Research Hospital, Memphis, before becoming Professor of Pediatrics at University of Tennessee, College of Medicine in 1987. In 1999 he moved to Dana–Farber Cancer Institute to become Vice Chair for Research in Pediatric Oncology and Professor of Pediatric Oncology at Harvard Medical School.

• 2004 ASCO Pediatric Oncology Lectureship Award, 40th Annual ASCO Mtg, New Orleans, LA.{{Cite web | url=https://www.asco.org/special-awards/all | title=All Award Recipients}}
• 2005 ASPHO Frank A. Oski Memorial Lectureship Award, May 15, 2005 Annual Mtg., Washington, DC.{{Cite web | url=http://aspho.org/career-development/awards/oski-lectureship | title=Oski Lectureship · ASPHO}}

• Discovery of highly recurrent activating Notch mutations in T-ALL (with Jon C. Aster){{cite journal|title=Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia|first1=Andrew P.|last1=Weng|first2=Adolfo A.|last2=Ferrando|first3=Woojoong|last3=Lee|first4=John P.|last4=Morris|first5=Lewis B.|last5=Silverman|first6=Cheryll|last6=Sanchez-Irizarry|first7=Stephen C.|last7=Blacklow|authorlink7=Stephen Blacklow|first8=A. Thomas|last8=Look|first9=Jon C.|last9=Aster|date=8 October 2004|journal=Science|volume=306|issue=5694|pages=269–271|doi=10.1126/science.1102160|pmid=15472075|bibcode=2004Sci...306..269W |citeseerx=10.1.1.459.5126|s2cid=24049536}}
• Discovery of somatic enhancer mutations activating TAL1{{cite journal|title=An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element|first1=Marc R.|last1=Mansour|first2=Brian J.|last2=Abraham|first3=Lars|last3=Anders|first4=Alla|last4=Berezovskaya|first5=Alejandro|last5=Gutierrez|first6=Adam D.|last6=Durbin|first7=Julia|last7=Etchin|first8=Lee|last8=Lawton|first9=Stephen E.|last9=Sallan|first10=Lewis B.|last10=Silverman|first11=Mignon L.|last11=Loh|first12=Stephen P.|last12=Hunger|first13=Takaomi|last13=Sanda|first14=Richard A.|last14=Young|first15=A. Thomas|last15=Look|date=12 December 2014|journal=Science|volume=346|issue=6215|pages=1373–1377|doi=10.1126/science.1259037|pmid=25394790|pmc=4720521|bibcode=2014Sci...346.1373M }}
• The first zebrafish model of cancer - MYC-induced T-ALL in the zebrafish{{cite journal|title=Myc-Induced T Cell Leukemia in Transgenic Zebrafish|first1=David M.|last1=Langenau|first2=David|last2=Traver|first3=Adolfo A.|last3=Ferrando|first4=Jeffery L.|last4=Kutok|first5=Jon C.|last5=Aster|first6=John P.|last6=Kanki|first7=Shuo|last7=Lin|first8=Ed|last8=Prochownik|first9=Nikolaus S.|last9=Trede|first10=Leonard I.|last10=Zon|first11=A. Thomas|last11=Look|date=7 February 2003|journal=Science|volume=299|issue=5608|pages=887–890|doi=10.1126/science.1080280|pmid=12574629|bibcode=2003Sci...299..887L |s2cid=38069481}}
• Use of gene expression profiling to define distinct oncogenic subgroups in T-ALL{{cite journal|title=Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo|first1=Akira|last1=Inoue|first2=Markus G.|last2=Seidel|first3=Wenshu|last3=Wu|first4=Shintaro|last4=Kamizono|first5=Adolfo A.|last5=Ferrando|first6=Roderick T.|last6=Bronson|first7=Hiromi|last7=Iwasaki|first8=Koichi|last8=Akashi|first9=Akira|last9=Morimoto|first10=Johann K.|last10=Hitzler|first11=Tamara I.|last11=Pestina|first12=Carl W.|last12=Jackson|first13=Ryuhei|last13=Tanaka|first14=Miriam J.|last14=Chong|first15=Peter J.|last15=McKinnon|first16=Takeshi|last16=Inukai|first17=Gerard C.|last17=Grosveld|first18=A.Thomas|last18=Look|date=1 October 2002|journal=Cancer Cell|volume=2|issue=4|pages=279–288|doi=10.1016/S1535-6108(02)00155-1|pmid=12398892|doi-access=free}}
• Discovery of CHK1 suppressed caspase-2 apoptotic pathway in response to DNA damage{{cite journal|title=Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3|first1=Samuel|last1=Sidi|first2=Takaomi|last2=Sanda|first3=Richard D.|last3=Kennedy|first4=Andreas T.|last4=Hagen|first5=Cicely A.|last5=Jette|first6=Raymond|last6=Hoffmans|first7=Jennifer|last7=Pascual|first8=Shintaro|last8=Imamura|first9=Shuji|last9=Kishi|first10=James F.|last10=Amatruda|first11=John P.|last11=Kanki|first12=Douglas R.|last12=Green|first13=Alan A.|last13=D'Andrea|first14=A. Thomas|last14=Look|date=30 May 2008|journal=Cell|volume=133|issue=5|pages=864–877|doi=10.1016/j.cell.2008.03.037|pmid=18510930|pmc=2719897}}
• Discovery of activating ALK mutations in neuroblastoma{{cite journal|title=Activating mutations in ALK provide a therapeutic target in neuroblastoma|first1=Rani E.|last1=George|first2=Takaomi|last2=Sanda|first3=Megan|last3=Hanna|first4=Stefan|last4=Fröhling|first5=William Luther|last5=II|first6=Jianming|last6=Zhang|first7=Yebin|last7=Ahn|first8=Wenjun|last8=Zhou|first9=Wendy B.|last9=London|first10=Patrick|last10=McGrady|first11=Liquan|last11=Xue|first12=Sergey|last12=Zozulya|first13=Vlad E.|last13=Gregor|first14=Thomas R.|last14=Webb|first15=Nathanael S.|last15=Gray|first16=D. Gary|last16=Gilliland|first17=Lisa|last17=Diller|first18=Heidi|last18=Greulich|first19=Stephan W.|last19=Morris|first20=Matthew|last20=Meyerson|first21=A. Thomas|last21=Look|date=1 October 2008|journal=Nature|volume=455|issue=7215|pages=975–978|doi=10.1038/nature07397|pmid=18923525|pmc=2587486|bibcode=2008Natur.455..975G }}
• Development of FISH to detect MYCN amplification in neuroblastoma{{cite journal|title=Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study|first1=Prasad|last1=Mathew|first2=Marcus B|last2=Valentine|first3=Laura C|last3=Bowman|first4=Susan T|last4=Rowe|first5=Michael B|last5=Nash|first6=Virginia A|last6=Valentine|first7=Susan L|last7=Cohn|first8=Robert P|last8=Castleberry|first9=Garrett M|last9=Brodeur|first10=A Thomas|last10=Look|date=1 March 2001|journal=Neoplasia (New York, N.Y.)|volume=3|issue=2|pages=105–109|pmid=11420745|pmc=1505416|doi = 10.1038/sj.neo.7900146}}
• Discovery of MET-HGF autocrine axis in AML{{cite journal|title=Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia|first1=Alex|last1=Kentsis|first2=Casie|last2=Reed|first3=Kim L|last3=Rice|first4=Takaomi|last4=Sanda|first5=Scott J|last5=Rodig|first6=Eleni|last6=Tholouli|first7=Amanda|last7=Christie|first8=Peter J M|last8=Valk|first9=Ruud|last9=Delwel|first10=Vu|last10=Ngo|first11=Jeffery L|last11=Kutok|first12=Suzanne E|last12=Dahlberg|first13=Lisa A|last13=Moreau|first14=Richard J|last14=Byers|first15=James G|last15=Christensen|first16=George Vande|last16=Woude|first17=Jonathan D|last17=Licht|first18=Andrew L|last18=Kung|first19=Louis M|last19=Staudt|first20=A Thomas|last20=Look|date=10 June 2012|journal=Nature Medicine|volume=18|issue=7|pages=1118–1122|doi=10.1038/nm.2819|pmid=22683780|pmc=3438345}}
• Core transcriptional circuitry of TAL1 complex{{cite journal|url= |title=Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia|first1=Takaomi|last1=Sanda|first2=Lee N.|last2=Lawton|first3=M. Inmaculada|last3=Barrasa|first4=Zi Peng|last4=Fan|first5=Holger|last5=Kohlhammer|first6=Alejandro|last6=Gutierrez|first7=Wenxue|last7=Ma|first8=Jessica|last8=Tatarek|first9=Yebin|last9=Ahn|first10=Michelle A.|last10=Kelliher|first11=Catriona H.M.|last11=Jamieson|first12=Louis M.|last12=Staudt|first13=Richard A.|last13=Young|first14=A. Thomas|last14=Look|date=1 August 2012|journal=Cancer Cell|volume=22|issue=2|pages=209–221|doi=10.1016/j.ccr.2012.06.007|pmid=22897851|pmc=3422504}}
• Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia{{cite journal|title=Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia|first1=Alejandro|last1=Gutierrez|first2=Li|last2=Pan|first3=Richard W.J.|last3=Groen|first4=Frederic|last4=Baleydier|first5=Alex|last5=Kentsis|first6=Jason|last6=Marineau|first7=Ruta|last7=Grebliunaite|first8=Elena|last8=Kozakewich|first9=Casie|last9=Reed|first10=Francoise|last10=Pflumio|first11=Sandrine|last11=Poglio|first12=Benjamin|last12=Uzan|first13=Paul|last13=Clemons|first14=Lynn|last14=VerPlank|first15=Frank|last15=An|first16=Jason|last16=Burbank|first17=Stephanie|last17=Norton|first18=Nicola|last18=Tolliday|first19=Hanno|last19=Steen|first20=Andrew P.|last20=Weng|first21=Huipin|last21=Yuan|first22=James E.|last22=Bradner|first23=Constantine|last23=Mitsiades|first24=A. Thomas|last24=Look|first25=Jon C.|last25=Aster|date=9 January 2014|journal=Journal of Clinical Investigation|volume=124|issue=2|pages=644–655|doi=10.1172/JCI65093|pmid=24401270|pmc=3904599}}
• Cloning and functional characterization of E2A-HLF in B-ALL{{cite journal|title=Chromosomal localization and cDNA cloning of the human DBP and TEF genes|first1=Z. A.|last1=Khatib|first2=T.|last2=Inaba|first3=M.|last3=Valentine|first4=A. T.|last4=Look|date=15 September 1994|journal=Genomics|volume=23|issue=2|pages=344–351|doi=10.1006/geno.1994.1510|pmid=7835883}}{{cite journal|title=Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor|first1=T.|last1=Inaba|first2=T.|last2=Inukai|first3=T.|last3=Yoshihara|first4=H.|last4=Seyschab|first5=R. A.|last5=Ashmun|first6=C. E.|last6=Canman|first7=S. J.|last7=Laken|first8=M. B.|last8=Kastan|first9=A. T.|last9=Look|date=8 August 1996|journal=Nature|volume=382|issue=6591|pages=541–544|doi=10.1038/382541a0|pmid=8700228|bibcode=1996Natur.382..541I |s2cid=4321391}}
• Discovery of the Slug survival pathway in hematopoietic stem cells
• Discovery of MYB duplications in T-ALL{{cite journal|title=Alu elements mediate MYB gene tandem duplication in human T-ALL|first1=Jennifer|last1=O'Neil|first2=Joelle|last2=Tchinda|first3=Alejandro|last3=Gutierrez|first4=Lisa|last4=Moreau|first5=Richard S.|last5=Maser|first6=Kwok-Kin|last6=Wong|first7=Wei|last7=Li|first8=Keith|last8=McKenna|first9=X. Shirley|last9=Liu|first10=Bin|last10=Feng|first11=Donna|last11=Neuberg|first12=Lewis|last12=Silverman|first13=Daniel J.|last13=DeAngelo|first14=Jeffery L.|last14=Kutok|first15=Rodney|last15=Rothstein|first16=Ronald A.|last16=DePinho|first17=Lynda|last17=Chin|first18=Charles|last18=Lee|first19=A. Thomas|last19=Look|date=24 December 2007|journal=Journal of Experimental Medicine|volume=204|issue=13|pages=3059–3066|doi=10.1084/jem.20071637|pmid=18070937|pmc=2150982}}
• Discovery of FBXW7 mutations in T-ALL{{cite journal|title=FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors|first1=Jennifer|last1=O'Neil|first2=Jonathan|last2=Grim|first3=Peter|last3=Strack|first4=Sudhir|last4=Rao|first5=Deanne|last5=Tibbitts|first6=Christopher|last6=Winter|first7=James|last7=Hardwick|first8=Markus|last8=Welcker|first9=Jules P.|last9=Meijerink|first10=Rob|last10=Pieters|first11=Giulio|last11=Draetta|first12=Rosalie|last12=Sears|first13=Bruce E.|last13=Clurman|first14=A. Thomas|last14=Look|date=6 August 2007|journal=Journal of Experimental Medicine|volume=204|issue=8|pages=1813–1824|doi=10.1084/jem.20070876|pmid=17646409|pmc=2118656}}
• Discovery of MYBL2 as the crucial 20q tumor suppressor in MDS{{cite journal|title=MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy|first1=Stefan|last1=Heinrichs|first2=Lillian F|last2=Conover|first3=Carlos E|last3=Bueso-Ramos|first4=Outi|last4=Kilpivaara|first5=Kristen|last5=Stevenson|first6=Donna|last6=Neuberg|first7=Mignon L|last7=Loh|first8=Wen-Shu|last8=Wu|first9=Scott J|last9=Rodig|first10=Guillermo|last10=Garcia-Manero|first11=Hagop M|last11=Kantarjian|first12=A Thomas|last12=Look|date=16 July 2013|journal=eLife|volume=2|pages=e00825|doi=10.7554/eLife.00825|pmid=23878725|pmc=3713455 |doi-access=free }}

{{Reflist}}

• {{GoogleScholar|cB00ntQAAAAJ}}
• [https://research.danafarberbostonchildrens.org/look/ A. Thomas Look Lab] at Dana-Farber Cancer Institute

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{{DEFAULTSORT:Look, A. Thomas}}

Category:Year of birth missing (living people)

Category:Living people

Category:American oncologists

Category:Harvard Medical School faculty

Category:University of Michigan Medical School alumni

Category:University of Michigan College of Engineering alumni

Category:University of Tennessee faculty