AADAC
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.{{cite journal | vauthors = Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R | title = Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. | journal = J Biol Chem | volume = 269 | issue = 34 | pages = 21650–6 |date=Sep 1994 | doi = 10.1016/S0021-9258(17)31855-0 | pmid = 8063807 | doi-access = free }}{{cite web | title = Entrez Gene: AADAC arylacetamide deacetylase (esterase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=13}}
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.
References
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Further reading
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- {{cite journal | vauthors=Probst MR, Jenö P, Meyer UA |title=Purification and characterization of a human liver arylacetamide deacetylase. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 1 |pages= 453–9 |year= 1991 |pmid= 2043131 |doi=10.1016/0006-291X(91)92005-5 }}
- {{cite journal | vauthors=Yamazaki K, Kusano K, Tadano K, Tanaka I |title=Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. |journal=Genomics |volume=44 |issue= 2 |pages= 248–50 |year= 1997 |pmid= 9299245 |doi= 10.1006/geno.1997.4879 }}
- {{cite journal | author=Ozols J |title=Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. |journal=Biochemistry |volume=37 |issue= 28 |pages= 10336–44 |year= 1998 |pmid= 9665742 |doi= 10.1021/bi9807916 }}
- {{cite journal | vauthors=Mziaut H, Korza G, Hand AR |title=Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14122–9 |year= 1999 |pmid= 10318829 |doi=10.1074/jbc.274.20.14122 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Trickett JI, Patel DD, Knight BL |title=Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39522–32 |year= 2001 |pmid= 11481320 |doi= 10.1074/jbc.M101764200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Saito S, Iida A, Sekine A |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249–70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Frick C, Atanasov AG, Arnold P |title=Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31131–8 |year= 2004 |pmid= 15152005 |doi= 10.1074/jbc.M313666200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
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External links
- {{UCSC genome browser|AADAC}}
- {{UCSC gene details|AADAC}}
{{DEFAULTSORT:Aadac}}
{{gene-3-stub}}