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AASDHPPT

{{Short description|Protein-coding gene in the species Homo sapiens}}

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L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is an enzyme that in humans is encoded by the AASDHPPT gene.{{cite journal |vauthors=Joshi AK, Zhang L, Rangan VS, Smith S | title = Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity | journal = J Biol Chem | volume = 278 | issue = 35 | pages = 33142–9 |date=Aug 2003 | pmid = 12815048 | doi = 10.1074/jbc.M305459200 | doi-access = free }}{{cite journal |vauthors=Praphanphoj V, Sacksteder KA, Gould SJ, Thomas GH, Geraghty MT | title = Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene | journal = Mol Genet Metab | volume = 72 | issue = 4 | pages = 336–42 |date=Apr 2001 | pmid = 11286508 | doi = 10.1006/mgme.2000.3138 }}{{cite web | title = Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60496}}

The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.

References

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Further reading

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  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | author = Mammalian Gene Collection Program Team | display-authors = 4 | last2 = Strausberg | first2 = R. L. | last3 = Feingold | first3 = E. A. | last4 = Grouse | first4 = L. H. | last5 = Derge | first5 = J. G. | last6 = Klausner | first6 = R. D. | last7 = Collins | first7 = F. S. | last8 = Wagner | first8 = L. | last9 = Shenmen | first9 = C. M. | last10 = Schuler | first10 = G. D. | doi = 10.1073/pnas.242603899 | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences | volume = 99 | issue = 26 | pages = 16899–16903 | pmc = 139241 | year = 2002 | pmid = 12477932| bibcode = 2002PNAS...9916899M | doi-access = free }}
  • {{cite journal |vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |display-authors=etal}}
  • {{cite journal |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |bibcode=2000PNAS...97.9543H |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876 |display-authors=etal}}

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External links

  • {{UCSC genome browser|AASDHPPT}}
  • {{UCSC gene details|AASDHPPT}}

{{PDB Gallery|geneid=60496}}

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