AATK
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | doi = 10.1093/dnares/5.3.169 | doi-access = free }}{{cite journal | vauthors = Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T | title = Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization | journal = Journal of Human Genetics | volume = 44 | issue = 2 | pages = 141–2 | date = Apr 1999 | pmid = 10083745 | doi = 10.1007/s100380050130 | doi-access = free }}{{cite web | title = Entrez Gene: AATK apoptosis-associated tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9625}}
Structure and expression
Function
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.{{cite journal | vauthors = Kos A, Olde Loohuis NF, Wieczorek ML, Glennon JC, Martens GJ, Kolk SM, Aschrafi A | title = A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase | journal = PLOS ONE | volume = 7 | issue = 2 | pages = e31022 | year = 2012 | pmid = 22363537 | pmc = 3281898 | doi = 10.1371/journal.pone.0031022 | bibcode = 2012PLoSO...731022K | doi-access = free }}
Its suppressive role on melanoma development has been reported recently.{{cite journal | vauthors = Ma S, Rubin BP | title = Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma | journal = Laboratory Investigation | volume = 94 | issue = 4 | pages = 430–438 | date = Apr 2014 | pmid = 24589855 | doi = 10.1038/labinvest.2014.13 | doi-access = free }}
AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.{{cite journal | vauthors = Gagnon KB, England R, Diehl L, Delpire E | s2cid = 10258460 | title = Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation | journal = American Journal of Physiology. Cell Physiology | volume = 292 | issue = 5 | pages = C1809–C1815 | date = May 2007 | pmid = 17267545 | doi = 10.1152/ajpcell.00580.2006 }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
- {{cite journal | vauthors = Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN, Phillips PC, Damodar Reddy C | title = A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line | journal = Brain Research. Molecular Brain Research | volume = 77 | issue = 2 | pages = 151–62 | date = May 2000 | pmid = 10837911 | doi = 10.1016/S0169-328X(00)00048-6 | doi-access = free }}
- {{cite journal | vauthors = Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, Yano R | title = Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain | journal = Brain Research. Molecular Brain Research | volume = 112 | issue = 1–2 | pages = 103–12 | date = Apr 2003 | pmid = 12670708 | doi = 10.1016/S0169-328X(03)00054-8 }}
- {{cite journal | vauthors = Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, Hisanaga S | title = Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 398–404 | date = Oct 2003 | pmid = 14521924 | doi = 10.1016/j.bbrc.2003.08.143 }}
- {{cite journal | vauthors = Piechotta K, Garbarini N, England R, Delpire E | title = Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase | journal = The Journal of Biological Chemistry | volume = 278 | issue = 52 | pages = 52848–56 | date = Dec 2003 | pmid = 14563843 | doi = 10.1074/jbc.M309436200 | doi-access = free }}
{{refend}}
External links
- {{UCSC genome browser|AATK}}
- {{UCSC gene details|AATK}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
{{DEFAULTSORT:Aatk}}
Category:Genes on human chromosome 17
Category:Tyrosine kinase receptors
{{Transmembranereceptor-stub}}