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ABCC4

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.{{cite web | title = Entrez Gene: ATP-binding cassette| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10257}}{{cite journal | vauthors = Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD | title = Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter | journal = Cancer Research | volume = 58 | issue = 13 | pages = 2741–7 | date = July 1998 | pmid = 9661885 }}

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.{{cite journal | vauthors = Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS | title = Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation | journal = The Journal of Clinical Investigation | volume = 118 | issue = 8 | pages = 2747–57 | date = August 2008 | pmid = 18636120 | pmc = 2467383 | doi = 10.1172/JCI35067 }} MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.{{cite journal | vauthors = Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M | display-authors = etal | year = 2003 | title = The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 16| pages = 9244–9 | doi = 10.1073/pnas.1033060100 | pmid = 12835412 | pmc = 170903 | bibcode = 2003PNAS..100.9244R | doi-access = free }}

MRP4/ABCC4 expression is dysregulated in several cancers {{cite journal | vauthors = Ho LL, Kench JG, Handelsman DJ, Scheffer GL, Stricker PD, Grygiel JG | display-authors = etal | year = 2008 | title = Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer | journal = Prostate | volume = 68 | issue = 13| pages = 1421–9 | doi = 10.1002/pros.20809 | pmid = 18615486 | s2cid = 42717909 }}{{cite journal | vauthors = Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG | display-authors = etal | year = 2011 | title = Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation | journal = J Biol Chem | volume = 286 | issue = 9| pages = 6979–88 | doi = 10.1074/jbc.m110.166868 | pmid = 21205825 | pmc = 3044954 | doi-access = free }}Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9. and is also upregulated in peritoneal endometriosis.{{cite journal | vauthors = Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO | year = 2013| title = Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4) | journal = Fertil Steril | volume = 99| issue = 7| pages = 1965–1973.e2| doi = 10.1016/j.fertnstert.2013.01.146 | pmid = 23472950| doi-access = free}}

Interactive pathway map

{{FluoropyrimidineActivity WP1601|highlight=ABCC4}}

See also

References

{{Reflist|33em}}

Further reading

{{refbegin|33em}}

  • {{cite journal | vauthors = Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N | title = Genetic susceptibility to distinct bladder cancer subphenotypes | journal = European Urology | volume = 57 | issue = 2 | pages = 283–92 | date = February 2010 | pmid = 19692168 | pmc = 3220186 | doi = 10.1016/j.eururo.2009.08.001 }}
  • {{cite journal | vauthors = Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR | title = Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score | journal = Molecular Medicine | volume = 16 | issue = 7–8 | pages = 247–53 | year = 2010 | pmid = 20379614 | pmc = 2896464 | doi = 10.2119/molmed.2009.00159 }}
  • {{cite journal | vauthors = Rodríguez-Nóvoa S, Labarga P, Soriano V, Egan D, Albalater M, Morello J, Cuenca L, González-Pardo G, Khoo S, Back D, Owen A | title = Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study | journal = Clinical Infectious Diseases | volume = 48 | issue = 11 | pages = e108-16 | date = June 2009 | pmid = 19400747 | doi = 10.1086/598507 | doi-access = free }}
  • {{cite journal | vauthors = Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP | title = Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies | journal = PLOS ONE | volume = 4 | issue = 12 | pages = e7960 | year = 2009 | pmid = 19956635 | pmc = 2778625 | doi = 10.1371/journal.pone.0007960 | bibcode = 2009PLoSO...4.7960H | editor1-last = Luo | editor1-first = Yuan | doi-access = free }}
  • {{cite journal | vauthors = Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF, Kim RB, Tirona RG | title = Human skeletal muscle drug transporters determine local exposure and toxicity of statins | journal = Circulation Research | volume = 106 | issue = 2 | pages = 297–306 | date = February 2010 | pmid = 19940267 | doi = 10.1161/CIRCRESAHA.109.203596 | doi-access = free | url = https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=3023&context=paedpub | url-access = subscription }}
  • {{cite journal | vauthors = Jedlitschky G, Cattaneo M, Lubenow LE, Rosskopf D, Lecchi A, Artoni A, Motta G, Niessen J, Kroemer HK, Greinacher A | title = Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies | journal = The American Journal of Pathology | volume = 176 | issue = 3 | pages = 1097–103 | date = March 2010 | pmid = 20133816 | pmc = 2832132 | doi = 10.2353/ajpath.2010.090425 }}
  • {{cite journal | vauthors = Saito A, Kawamoto M, Kamatani N | title = Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects | journal = Journal of Human Genetics | volume = 54 | issue = 6 | pages = 317–23 | date = June 2009 | pmid = 19343046 | doi = 10.1038/jhg.2009.31 | doi-access = free }}
  • {{cite journal | vauthors = Hosgood HD, Menashe I, He X, Chanock S, Lan Q | title = PTEN identified as important risk factor of chronic obstructive pulmonary disease | journal = Respiratory Medicine | volume = 103 | issue = 12 | pages = 1866–70 | date = December 2009 | pmid = 19625176 | pmc = 2783799 | doi = 10.1016/j.rmed.2009.06.016 }}
  • {{cite journal | vauthors = Ban H, Andoh A, Imaeda H, Kobori A, Bamba S, Tsujikawa T, Sasaki M, Saito Y, Fujiyama Y | title = The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease | journal = Journal of Gastroenterology | volume = 45 | issue = 10 | pages = 1014–21 | date = October 2010 | pmid = 20393862 | doi = 10.1007/s00535-010-0248-y | s2cid = 586429 }}
  • {{cite journal | vauthors = Kucka M, Kretschmannova K, Murano T, Wu CP, Zemkova H, Ambudkar SV, Stojilkovic SS | title = Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance | journal = Molecular Pharmacology | volume = 77 | issue = 2 | pages = 270–9 | date = February 2010 | pmid = 19903828 | pmc = 2812068 | doi = 10.1124/mol.109.059386 }}
  • {{cite journal | vauthors = Aleksunes LM, Yeager RL, Klaassen CD | title = Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers | journal = Xenobiotica | volume = 39 | issue = 7 | pages = 514–22 | date = July 2009 | pmid = 19480556 | pmc = 2698955 | doi = 10.1080/00498250902952514 }}
  • {{cite journal | vauthors = Ming X, Thakker DR | title = Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil | journal = Biochemical Pharmacology | volume = 79 | issue = 3 | pages = 455–62 | date = February 2010 | pmid = 19735648 | doi = 10.1016/j.bcp.2009.08.029 }}
  • {{cite journal | vauthors = Brüggemann M, Trautmann H, Hoelzer D, Kneba M, Gökbuget N, Raff T | title = Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia | journal = Blood | volume = 114 | issue = 26 | pages = 5400–1; author reply 5401–2 | date = December 2009 | pmid = 20018925 | doi = 10.1182/blood-2009-09-243741 | doi-access = free }}
  • {{cite journal | vauthors = Clemente MI, Alvarez S, Serramía MJ, Turriziani O, Genebat M, Leal M, Fresno M, Muñoz-Fernández MA | title = Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4 | journal = Antiviral Therapy | volume = 14 | issue = 8 | pages = 1101–11 | year = 2009 | pmid = 20032540 | doi = 10.3851/IMP1468 | s2cid = 30947345 | doi-access = free }}
  • {{cite journal | vauthors = Radilova H, Libra A, Holasova S, Safarova M, Viskova A, Kunc F, Buncek M | title = COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells | journal = Molecular and Cellular Biochemistry | volume = 330 | issue = 1–2 | pages = 131–40 | date = October 2009 | pmid = 19399588 | doi = 10.1007/s11010-009-0126-1 | s2cid = 25586752 }}
  • {{cite journal | vauthors = Low SK, Kiyotani K, Mushiroda T, Daigo Y, Nakamura Y, Zembutsu H | title = Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients | journal = Journal of Human Genetics | volume = 54 | issue = 10 | pages = 564–71 | date = October 2009 | pmid = 19696793 | doi = 10.1038/jhg.2009.79 | doi-access = free }}
  • {{cite journal | vauthors = Ansari M, Sauty G, Labuda M, Gagné V, Laverdière C, Moghrabi A, Sinnett D, Krajinovic M | title = Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia | journal = Blood | volume = 114 | issue = 7 | pages = 1383–6 | date = August 2009 | pmid = 19515727 | doi = 10.1182/blood-2008-11-191098 | doi-access = free }}
  • {{cite journal | vauthors = Yuasa I, Umetsu K, Matsusue A, Nishimukai H, Harihara S, Fukumori Y, Saitou N, Jin F, Chattopadhyay PK, Henke L, Henke J | title = A Japanese-specific allele in the GALNT11 gene | journal = Legal Medicine | volume = 12 | issue = 4 | pages = 208–11 | date = July 2010 | pmid = 20547088 | doi = 10.1016/j.legalmed.2010.04.001 }}
  • {{cite journal | vauthors = Moyer AM, Sun Z, Batzler AJ, Li L, Schaid DJ, Yang P, Weinshilboum RM | title = Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 19 | issue = 3 | pages = 811–21 | date = March 2010 | pmid = 20200426 | pmc = 2837367 | doi = 10.1158/1055-9965.EPI-09-0871 }}
  • {{cite journal | vauthors = Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL | title = Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression | journal = American Journal of Physiology. Gastrointestinal and Liver Physiology | volume = 299 | issue = 1 | pages = G126-35 | date = July 2010 | pmid = 20395535 | pmc = 2904108 | doi = 10.1152/ajpgi.00522.2010 }}

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External links

  • {{MeshName|ABCC4+protein,+human}}
  • {{UCSC gene info|ABCC4}}

{{ABC transporters}}

{{DEFAULTSORT:Abcc4}}

Category:ATP-binding cassette transporters