ABL2

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.{{cite journal|last1=Nagy|first1=Ádám|last2=Pongor|first2=Lőrinc Sándor|last3=Szabó|first3=András|last4=Santarpia|first4=Mariacarmela|last5=Győrffy|first5=Balázs|date=2017-02-15|title=KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer|journal=International Journal of Cancer|volume=140|issue=4|pages=930–937|doi=10.1002/ijc.30509|issn=1097-0215|pmc=5299512|pmid=27859136}} The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.

ABL2 has been shown to interact with three proteins: Abl gene,{{cite journal |vauthors=Cao C, Leng Y, Li C, Kufe D | title = Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 12961–7 |date=April 2003 | pmid = 12569093 | doi = 10.1074/jbc.M300058200 | doi-access = free }} catalase,{{cite journal |vauthors=Cao C, Leng Y, Kufe D | title = Catalase activity is regulated by c-Abl and Arg in the oxidative stress response | journal = J. Biol. Chem. | volume = 278 | issue = 32 | pages = 29667–75 |date=August 2003 | pmid = 12777400 | doi = 10.1074/jbc.M301292200 | doi-access = free }} and SORBS2.{{cite journal |vauthors=Wang B, Golemis EA, Kruh GD | title = ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks | journal = J. Biol. Chem. | volume = 272 | issue = 28 | pages = 17542–50 |date=July 1997 | pmid = 9211900 | doi = 10.1074/jbc.272.28.17542| doi-access = free | hdl = 20.500.12613/9174 | hdl-access = free }} The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.{{cite journal |vauthors=Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B | title = Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides | journal = Science | volume = 253 | issue = 5019 | pages = 562–5 |date=August 1991 | pmid = 1857987 | doi = 10.1126/science.1857987 | bibcode = 1991Sci...253..562S }} Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.{{cite journal |vauthors=Chelikani P, Fita I, Loewen PC | title = Diversity of structures and properties among catalases | journal = Cell. Mol. Life Sci. | volume = 61 | issue = 2 | pages = 192–208 | date = January 2004 | pmid = 14745498 | doi = 10.1007/s00018-003-3206-5 | hdl = 10261/111097 | s2cid = 4411482 | hdl-access = free }} SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 |date=Apr 1999 | pmid = 9872452 | doi =10.1093/dnares/5.5.277 | doi-access = free }}

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• {{MeshName|Genes,+abl}}
• {{MeshName|Abelson+Leukemia+Virus}}
• [https://web.archive.org/web/20110704224355/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=27 ABL2] Info with links in the [https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml Cell Migration Gateway]
• {{UCSC gene info|ABL2}}

{{PDB Gallery|geneid=27}}

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Category:Tyrosine kinases

Category:Oncogenes