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ACER2

{{Short description|Ceramidase enzyme}}

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{{Infobox_gene}}

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.{{cite journal |vauthors=Mao C, Obeid LM | title = Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate | journal = Biochim. Biophys. Acta | volume = 1781 | issue = 9 | pages = 424–34 |date=September 2008 | pmid = 18619555 | doi = 10.1016/j.bbalip.2008.06.002 | pmc = 2614331 }}

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.{{cite journal |vauthors=Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C | title = Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion | journal = FASEB J. | volume = 23 | issue = 2 | pages = 656–66 |date=February 2009 | pmid = 18945876 | doi = 10.1096/fj.08-115634 | doi-access = free | pmc = 2630785 }}

References

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External links

  • {{UCSC gene info|ACER2}}

Further reading

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  • {{cite journal |vauthors=Xu R, Jin J, Hu W |title=Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1813–25 |year= 2006 |pmid= 16940153 |doi= 10.1096/fj.05-5689com|doi-access=free |s2cid=20973940 |display-authors=etal}}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 |pmc=2734081 |bibcode=2004Natur.429..369H |display-authors=etal}}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
  • {{cite journal |vauthors=Wan D, Gong Y, Qin W |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 |pmc=524842|bibcode=2004PNAS..10115724W |display-authors=etal|doi-access=free }}

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{{Glycolipid/sphingolipid metabolism enzymes}}

Category:Human proteins

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