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ACTG2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.{{cite journal |vauthors=Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T | title = Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes | journal = Mol Cell Biol | volume = 11 | issue = 6 | pages = 3296–306 |date=July 1991 | pmid = 1710027 | pmc = 360182 | doi = 10.1128/mcb.11.6.3296}}{{cite journal | author = Ueyama H | title = A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG) | journal = Nucleic Acids Res | volume = 19 | issue = 2 | pages = 411 |date=May 1991 | pmid = 1673027 | pmc = 333620 | doi =10.1093/nar/19.2.411 }}{{cite web | title = Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=72}}

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.

Interactions

ACTG2 has been shown to interact with Emerin.{{cite journal |doi=10.1016/S0006-291X(03)00415-7 |last=Lattanzi |first=Giovanna |author2=Cenni Vittoria |author3=Marmiroli Sandra |author4=Capanni Cristina |author5=Mattioli Elisabetta |author6=Merlini Luciano |author7=Squarzoni Stefano |author8=Maraldi Nadir Mario |date=April 2003 |title=Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue=3 |pages=764–70 |location = United States| issn = 0006-291X| pmid = 12670476 }}

References

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External links

  • {{UCSC gene info|ACTG2}}

Further reading

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  • {{cite journal |vauthors=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi= 10.1007/BF02818986|s2cid=7617882 }}
  • {{cite journal |vauthors=Adams LD, Tomasselli AG, Robbins P |title=HIV-1 protease cleaves actin during acute infection of human T-lymphocytes |journal=AIDS Res. Hum. Retroviruses |volume=8 |issue= 2 |pages= 291–5 |year= 1992 |pmid= 1540415 |doi=10.1089/aid.1992.8.291 |display-authors=etal|url=https://zenodo.org/record/1235231 }}
  • {{cite journal |vauthors=Tomasselli AG, Hui JO, Adams L |title=Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14548–53 |year= 1991 |doi=10.1016/S0021-9258(18)98721-1 |pmid= 1907279 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Shoeman RL, Kesselmier C, Mothes E |title=Non-viral cellular substrates for human immunodeficiency virus type 1 protease |journal=FEBS Lett. |volume=278 |issue= 2 |pages= 199–203 |year= 1991 |pmid= 1991513 |doi=10.1016/0014-5793(91)80116-K |s2cid=37002682 |display-authors=etal|doi-access=free |bibcode=1991FEBSL.278..199S }}
  • {{cite journal |vauthors=Miwa T, Kamada S |title=The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA |journal=Nucleic Acids Res. |volume=18 |issue= 14 |pages= 4263 |year= 1990 |pmid= 2377475 |doi=10.1093/nar/18.14.4263 | pmc=331204 }}
  • {{cite journal |vauthors=Ueyama H, Inazawa J, Nishino H |title=Chromosomal mapping of the human smooth muscle actin gene (enteric type, ACTA3) to 2p13.1 and molecular nature of the hindIII polymorphism |journal=Genomics |volume=25 |issue= 3 |pages= 720–3 |year= 1995 |pmid= 7759108 |doi=10.1016/0888-7543(95)80016-F |display-authors=etal}}
  • {{cite journal |vauthors=Szucsik JC, Lessard JL |title=Cloning and sequence analysis of the mouse smooth muscle gamma-enteric actin gene |journal=Genomics |volume=28 |issue= 2 |pages= 154–62 |year= 1996 |pmid= 8530021 |doi= 10.1006/geno.1995.1126 }}
  • {{cite journal |vauthors=Bukrinskaya A, Brichacek B, Mann A, Stevenson M |title=Establishment of a Functional Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcription Complex Involves the Cytoskeleton |journal=J. Exp. Med. |volume=188 |issue= 11 |pages= 2113–25 |year= 1999 |pmid= 9841925 |doi=10.1084/jem.188.11.2113 | pmc=2212381 }}
  • {{cite journal |vauthors=Zhang H, Wang L, Kao S |title=Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF |journal=Curr. Biol. |volume=9 |issue= 21 |pages= 1271–4 |year= 1999 |pmid= 10556093 |doi=10.1016/S0960-9822(99)80511-9 |display-authors=etal|pmc=4513661 |bibcode=1999CBio....9.1271Z }}
  • {{cite journal |vauthors=Kohnen G, Campbell S, Jeffers MD, Cameron IT |title=Spatially regulated differentiation of endometrial vascular smooth muscle cells |journal=Hum. Reprod. |volume=15 |issue= 2 |pages= 284–92 |year= 2000 |pmid= 10655297 |doi=10.1093/humrep/15.2.284 |doi-access=free }}
  • {{cite journal |vauthors=Filmore RA, Dean DA, Zimmer WE |title=The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia |journal=Gene Expr. |volume=10 |issue= 5–6 |pages= 201–11 |year= 2003 |pmid= 12450213 |doi= 10.3727/000000002783992424|doi-broken-date=1 November 2024 |pmc=5977519 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Cheng C, Sharp PA |title=RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 1961–7 |year= 2003 |pmid= 12612070 |doi=10.1128/MCB.23.6.1961-1967.2003 | pmc=149466 }}
  • {{cite journal |vauthors=Wu RF, Gu Y, Xu YC |title=Human Immunodeficiency Virus Type 1 Tat Regulates Endothelial Cell Actin Cytoskeletal Dynamics through PAK1 Activation and Oxidant Production |journal=J. Virol. |volume=78 |issue= 2 |pages= 779–89 |year= 2004 |pmid= 14694110 |doi=10.1128/JVI.78.2.779-789.2004 | pmc=368750 |display-authors=etal}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal|bibcode=2005Natur.434..724H |doi-access=free }}

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{{PDB Gallery|geneid=72}}

{{Cytoskeletal Proteins}}

Category:Human proteins

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