ACTL6B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.{{cite journal |vauthors=Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes |journal=Genome Res |volume=8 |issue=10 |pages=1060–73 |date=December 1998 |pmid=9799793 |pmc=310788 |doi=10.1101/gr.8.10.1060}}{{cite web |title=Entrez Gene: ACTL6B actin-like 6B |url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51412}}
Function
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Interactions
ACTL6B has been shown to interact with CTBP1.{{cite journal |vauthors=Oma Y, Nishimori K, Harata M |title=The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=2 |pages=521–528 |date=February 2003 |pmid=12565893 |doi=10.1016/S0006-291X(02)03073-5}}
References
{{Reflist}}
External links
- {{UCSC gene info|ACTL6B}}
Further reading
{{Refbegin|2}}
- {{cite journal |vauthors=Schafer DA, Schroer TA |title=Actin-related proteins |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |pages=341–363 |year=2000 |pmid=10611965 |doi=10.1146/annurev.cellbio.15.1.341}}
- {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue=11 |pages=1097–108 |year=1999 |pmid=9847074 |doi=10.1101/gr.8.11.1097 |last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free}}
- {{cite journal |vauthors=Harata M, Mochizuki R, Mizuno S |title=Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues |journal=Biosci. Biotechnol. Biochem. |volume=63 |issue=5 |pages=917–923 |year=1999 |pmid=10380635 |doi=10.1271/bbb.63.917|doi-access=free }}
- {{cite journal |vauthors=Olave I, Wang W, Xue Y, Kuo A, Crabtree GR |title=Identification of a polymorphic, neuron-specific chromatin remodeling complex |journal=Genes Dev. |volume=16 |issue=19 |pages=2509–2517 |year=2002 |pmid=12368262 |pmc=187451 |doi=10.1101/gad.992102}}
- {{cite journal |vauthors=Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M |title=Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue=2 |pages=328–334 |year=2003 |pmid=12437990 |doi=10.1016/S0006-291X(02)02637-2}}
- {{cite journal |vauthors=Oma Y, Nishimori K, Harata M |title=The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=2 |pages=521–528 |year=2003 |pmid=12565893 |doi=10.1016/S0006-291X(02)03073-5}}
{{Refend}}
{{Gene-7-stub}}