ACVR2A

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

ACVR2A has been shown to interact with:

• ACVR1B,{{cite journal | vauthors = Lebrun JJ, Takabe K, Chen Y, Vale W | title = Roles of pathway-specific and inhibitory Smads in activin receptor signaling | journal = Mol. Endocrinol. | volume = 13 | issue = 1 | pages = 15–23 | date = January 1999 | pmid = 9892009 | doi = 10.1210/mend.13.1.0218 | s2cid = 26825706 | doi-access = free }}{{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34 | date = May 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}
• INHBA,{{cite journal | vauthors = Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W | title = Betaglycan binds inhibin and can mediate functional antagonism of activin signalling | journal = Nature | volume = 404 | issue = 6776 | pages = 411–4 | date = March 2000 | pmid = 10746731 | doi = 10.1038/35006129 | bibcode = 2000Natur.404..411L | s2cid = 4393629 }}{{cite journal | vauthors = Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH | title = Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells | journal = Endocrinology | volume = 138 | issue = 7 | pages = 2928–36 | date = July 1997 | pmid = 9202237 | doi = 10.1210/endo.138.7.5250 | doi-access = free }} and
• SYNJ2BP.{{cite journal | vauthors = Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H | title = Novel factors in regulation of activin signaling | journal = Mol. Cell. Endocrinol. | volume = 225 | issue = 1–2 | pages = 1–8 | date = October 2004 | pmid = 15451561 | doi = 10.1016/j.mce.2004.02.006 | s2cid = 34666659 }}{{cite journal | vauthors = Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H | title = Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19008–18 | date = May 2002 | pmid = 11882656 | doi = 10.1074/jbc.M112472200 | doi-access = free }}

{{reflist}}

• {{UCSC gene info|ACVR2A}}

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• {{cite journal | vauthors = Welt CK | title = The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction | journal = Curr. Opin. Obstet. Gynecol. | volume = 14 | issue = 3 | pages = 317–23 | year = 2002 | pmid = 12032389 | doi = 10.1097/00001703-200206000-00012 | s2cid = 44327401 }}
• {{cite journal | vauthors = Matzuk MM, Bradley A | title = Cloning of the human activin receptor cDNA reveals high evolutionary conservation | journal = Biochim. Biophys. Acta | volume = 1130 | issue = 1 | pages = 105–8 | year = 1992 | pmid = 1311955 | doi = 10.1016/0167-4781(92)90472-C }}
• {{cite journal | vauthors = Mathews LS, Vale WW | title = Expression cloning of an activin receptor, a predicted transmembrane serine kinase | journal = Cell | volume = 65 | issue = 6 | pages = 973–82 | year = 1991 | pmid = 1646080 | doi = 10.1016/0092-8674(91)90549-E | s2cid = 36407277 }}
• {{cite journal | vauthors = Xu J, McKeehan K, Matsuzaki K, McKeehan WL | title = Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism | journal = J. Biol. Chem. | volume = 270 | issue = 11 | pages = 6308–13 | year = 1995 | pmid = 7890768 | doi = 10.1074/jbc.270.11.6308 | doi-access = free }}
• {{cite journal | vauthors = Attisano L, Cárcamo J, Ventura F, Weis FM, Massagué J, Wrana JL | title = Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors | journal = Cell | volume = 75 | issue = 4 | pages = 671–80 | year = 1993 | pmid = 8242742 | doi = 10.1016/0092-8674(93)90488-C | s2cid = 25408172 }}
• {{cite journal | vauthors = Peng C, Huang TH, Jeung EB, Donaldson CJ, Vale WW, Leung PC | title = Expression of the type II activin receptor gene in the human placenta | journal = Endocrinology | volume = 133 | issue = 6 | pages = 3046–9 | year = 1993 | pmid = 8243335 | doi = 10.1210/endo.133.6.8243335 }}
• {{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34 | year = 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}
• {{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066–73 | year = 1996 | pmid = 8622651 | pmc = 231089 | doi = 10.1128/mcb.16.3.1066}}
• {{cite journal | vauthors = Liu QY, Niranjan B, Gomes P, Gomm JJ, Davies D, Coombes RC, Buluwela L | title = Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells | journal = Cancer Res. | volume = 56 | issue = 5 | pages = 1155–63 | year = 1996 | pmid = 8640777 }}
• {{cite journal | vauthors = Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K | title = Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 | journal = J. Biol. Chem. | volume = 271 | issue = 35 | pages = 21345–52 | year = 1996 | pmid = 8702914 | doi = 10.1074/jbc.271.35.21345 | doi-access = free }}
• {{cite journal | vauthors = Lebrun JJ, Vale WW | title = Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1682–91 | year = 1997 | pmid = 9032295 | pmc = 231893 | doi = 10.1128/mcb.17.3.1682}}
• {{cite journal | vauthors = Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL | title = Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25628–36 | year = 1998 | pmid = 9748228 | doi = 10.1074/jbc.273.40.25628 | doi-access = free }}
• {{cite journal | vauthors = Barbara NP, Wrana JL, Letarte M | title = Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 584–94 | year = 1999 | pmid = 9872992 | doi = 10.1074/jbc.274.2.584 | doi-access = free }}
• {{cite journal | vauthors = Lux A, Attisano L, Marchuk DA | title = Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1 | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 9984–92 | year = 1999 | pmid = 10187774 | doi = 10.1074/jbc.274.15.9984 | doi-access = free }}
• {{cite journal | vauthors = D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM | title = Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors | journal = J. Clin. Endocrinol. Metab. | volume = 84 | issue = 5 | pages = 1716–21 | year = 1999 | doi = 10.1210/jcem.84.5.5704 | pmid = 10323406 }}
• {{cite journal | vauthors = Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T | title = Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation | journal = J. Cell Sci. | volume = 112 | issue = 20 | pages = 3519–27 | year = 1999 | doi = 10.1242/jcs.112.20.3519 | pmid = 10504300 }}
• {{cite journal | vauthors = van Schaik RH, Wierikx CD, Timmerman MA, Oomen MH, van Weerden WM, van der Kwast TH, van Steenbrugge GJ, de Jong FH | title = Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues | journal = Br. J. Cancer | volume = 82 | issue = 1 | pages = 112–7 | year = 2000 | pmid = 10638976 | pmc = 2363208 | doi = 10.1054/bjoc.1999.0886 }}
• {{cite journal | vauthors = Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H | title = Identification and characterization of a PDZ protein that interacts with activin type II receptors | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5485–92 | year = 2000 | pmid = 10681527 | doi = 10.1074/jbc.275.8.5485 | doi-access = free }}

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Category:GS domain

Category:TS domain

Category:S/T domain

Category:Human proteins

Category:EC 2.7.11